公开(公告)号：US20050014280A1

公开(公告)日：2005-01-20

申请号：US10840469

申请日：2004-05-05

申请人： Junan Guo ,  Ping He ,  Anthony Qu ,  Steve Yang ,  Shabbir Anik

发明人： Junan Guo ,  Ping He ,  Anthony Qu ,  Steve Yang ,  Shabbir Anik

IPC分类号： G01N15/08 ,  G01N30/52 ,  G01N30/86 ,  G01N30/89 ,  G01N31/16

CPC分类号： G01N30/8693 ,  G01N15/08 ,  G01N30/89 ,  G01N2030/527

摘要： The present invention provides a method for determining drug permeability, wherein the method comprises, for each reference drug of at least two reference drugs having (i) the same ionization state at a given pH and (ii) a known drug permeability determined by the same drug permeability testing technique, the calculation of a metric related to retention time of each reference compound eluted from a liquid chromatography column having an immobilized artificial membrane functional group. Then, based on each metric and each known drug permeability, drug permeability is expressed as a function of the metric. The method may further comprise the calculation of the metric related to retention time for a further drug eluted from the liquid chromatography column, the further drug having the same ionization state at the given pH and an unknown drug permeability, and an assessment of drug permeability for the further drug, based on the metric for the further drug and the function.

摘要翻译： 本发明提供了一种用于测定药物渗透性的方法，其中所述方法包括至少两种参考药物的每种参考药物，所述参考药物具有（i）在给定pH下具有相同的电离状态，以及（ii）由相同的 药物渗透性测试技术，计算与具有固定的人造膜官能团的液相色谱柱洗脱的每个参考化合物的保留时间相关的度量。 然后，基于每个度量和每个已知的药物渗透性，药物渗透性被表示为度量的函数。 该方法还可以包括与从液相色谱柱洗脱的另外药物的保留时间相关的度量的计算，所述另外的药物在给定pH下具有相同的电离状态和未知的药物通透性，以及药物通透性的评估 进一步的药物，基于进一步药物和功能的指标。