公开(公告)号：US20180164275A1

公开(公告)日：2018-06-14

申请号：US15570030

申请日：2016-04-29

申请人： Avraham Arthur KOMILOSH ,  Dalia PINKERT

发明人： Avraham Arthur KOMILOSH ,  Dalia PINKERT

IPC分类号： G01N33/44 ,  C08G69/10 ,  G01N21/47 ,  G01N30/89 ,  G01N30/06 ,  C08G69/46

CPC分类号： G01N33/442 ,  C08G69/10 ,  C08G69/46 ,  G01N21/47 ,  G01N30/06 ,  G01N30/74 ,  G01N30/89 ,  G01N33/68 ,  G01N2021/4711

摘要： The present invention provides a process for characterizing a glatiramer acetate, related drug substance (GARDS) or a glatiramer acetate related drug product (GARDP) comprising separating a batch of a GARDS or GARDP according to hydrophobicity and determining the molar mass of the separated material, thereby characterizing the GARDS or GARDP by molar mass as a function of hydrophobicity.

公开(公告)号：US20160349273A1

公开(公告)日：2016-12-01

申请号：US14902754

申请日：2014-06-25

申请人： FORSCHUNGSZENTRUM JÜLICH GMBH

发明人： Luitgard NAGEL_STEGER ,  Oleksandr BRENER ,  Lothar GREMER ,  Dieter WILLBOLD

IPC分类号： G01N33/68 ,  B01D15/32 ,  G01N30/89

CPC分类号： G01N33/6896 ,  B01D15/325 ,  G01N30/89 ,  G01N33/6845 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2500/20 ,  G01N2800/2821

摘要： A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising: providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape; adding an active ingredient to be analyzed to the sample solution; separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape; optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks; determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.

摘要翻译： 一种用于定量表征样品中淀粉样蛋白和/或聚集的肽和/或蛋白质的方法，包括：提供样品，其中所述样品包括具有至少一个聚集体尺寸和形状的淀粉样蛋白和/或聚集的肽和/或蛋白质 ; 将待分析的活性成分加入到样品溶液中; 淀粉样蛋白和/或聚集的肽和/或蛋白质的分离根据它们的聚集体大小和形状彼此分离; 任选地使特定级分的淀粉样蛋白和/或聚集的肽和/或蛋白质完全变性成单体结构单元; 通过与没有活性成分的对照值进行比较，确定至少一个馏分中肽和/或蛋白质结构单元的浓度变化。

公开(公告)号：US07422625B2

公开(公告)日：2008-09-09

申请号：US11852655

申请日：2007-09-10

申请人： Andrew Tipler ,  Neil T. Plant

发明人： Andrew Tipler ,  Neil T. Plant

IPC分类号： B01D53/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a unit flow per unit pressure based on a ratio of the flow rate and the differential pressure. In certain embodiments, the flow rate at the outlet is established by controlling the flow rate of the gas. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 所公开的系统和方法包括提供具有入口和出口的容器，用于使载气通过该容器; 确定出口处的已知流速的入口和出口之间的压差; 并且基于流量和压差的比率确定单位压力的单位流量。 在某些实施例中，通过控制气体的流量来建立出口处的流量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于在输出处的气体压力与环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US07267709B2

公开(公告)日：2007-09-11

申请号：US11559760

申请日：2006-11-14

申请人： Andrew Tipler ,  Neil T. Plant

发明人： Andrew Tipler ,  Neil T. Plant

IPC分类号： B01D53/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US07111494B2

公开(公告)日：2006-09-26

申请号：US11072829

申请日：2005-03-04

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US20050014280A1

公开(公告)日：2005-01-20

申请号：US10840469

申请日：2004-05-05

申请人： Junan Guo ,  Ping He ,  Anthony Qu ,  Steve Yang ,  Shabbir Anik

发明人： Junan Guo ,  Ping He ,  Anthony Qu ,  Steve Yang ,  Shabbir Anik

IPC分类号： G01N15/08 ,  G01N30/52 ,  G01N30/86 ,  G01N30/89 ,  G01N31/16

CPC分类号： G01N30/8693 ,  G01N15/08 ,  G01N30/89 ,  G01N2030/527

摘要： The present invention provides a method for determining drug permeability, wherein the method comprises, for each reference drug of at least two reference drugs having (i) the same ionization state at a given pH and (ii) a known drug permeability determined by the same drug permeability testing technique, the calculation of a metric related to retention time of each reference compound eluted from a liquid chromatography column having an immobilized artificial membrane functional group. Then, based on each metric and each known drug permeability, drug permeability is expressed as a function of the metric. The method may further comprise the calculation of the metric related to retention time for a further drug eluted from the liquid chromatography column, the further drug having the same ionization state at the given pH and an unknown drug permeability, and an assessment of drug permeability for the further drug, based on the metric for the further drug and the function.

摘要翻译： 本发明提供了一种用于测定药物渗透性的方法，其中所述方法包括至少两种参考药物的每种参考药物，所述参考药物具有（i）在给定pH下具有相同的电离状态，以及（ii）由相同的 药物渗透性测试技术，计算与具有固定的人造膜官能团的液相色谱柱洗脱的每个参考化合物的保留时间相关的度量。 然后，基于每个度量和每个已知的药物渗透性，药物渗透性被表示为度量的函数。 该方法还可以包括与从液相色谱柱洗脱的另外药物的保留时间相关的度量的计算，所述另外的药物在给定pH下具有相同的电离状态和未知的药物通透性，以及药物通透性的评估 进一步的药物，基于进一步药物和功能的指标。

公开(公告)号：US06829540B1

公开(公告)日：2004-12-07

申请号：US09486168

申请日：2000-02-22

申请人： Charles Pidgeon ,  Hanlan Liu ,  Kimberly Hauer ,  Jianming Yin ,  Song J. Cai

发明人： Charles Pidgeon ,  Hanlan Liu ,  Kimberly Hauer ,  Jianming Yin ,  Song J. Cai

IPC分类号： G01N3348

CPC分类号： G01N33/5076 ,  G01N30/02 ,  G01N30/89 ,  G06F19/704 ,  B01D15/3852

摘要： The measurement of multiple membrane affinities of test compounds, methods and compositions useful for acquiring data characteristic of such affinities, and a method and system for using such data alone or in combination with other molecular descriptors for the prediction of biological activity are described. The numerical values characteristic of biologically relevant interaction of test compounds with membrane mimetic surfaces are compared with corresponding values of one or more control compounds having a known biological activity. Probable biological activity of a test compound is identified with those control compounds whose multiple membrane interaction values most closely correlate to those of the test compound.

摘要翻译： 描述了测试化合物的多个膜亲和力的测量，用于获得这种亲和力特征的方法和组合物，以及单独使用这些数据或与其他分子描述符组合用于预测生物活性的方法和系统。 将测试化合物与膜模拟表面的生物相关相互作用特征的数值与具有已知生物活性的一种或多种对照化合物的相应值进行比较。 用多个膜相互作用值与测试化合物的最密切相关的那些对照化合物鉴定测试化合物的可能的生物学活性。

公开(公告)号：US06387268B1

公开(公告)日：2002-05-14

申请号：US09619505

申请日：2000-07-19

申请人： Irving Wainer ,  Yanxiao Zhang

发明人： Irving Wainer ,  Yanxiao Zhang

IPC分类号： B01D1508

CPC分类号： B01D15/3804 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3242 ,  B01J20/3246 ,  B01J20/3251 ,  B01J20/3274 ,  B01J2220/54 ,  B01J2220/58 ,  G01N30/02 ,  G01N30/48 ,  G01N30/7233 ,  G01N30/89 ,  G01N2030/527

摘要： This invention provides a immobilized receptors on supports in liquid chromatographic systems. The method of the invention provides means of evaluating the attachment of agents to receptors comprising the steps of: (a) immobilizing receptors on artificial membrane supports in a column, (b) exposing the supports with the receptors to test agents at varying concentrations in a liquid chromatographic system, (c) eluting the test agent from the column, and (d) evaluating the elution profile of the test materials from the column. Using this method, it is possible to evaluate the interaction of the test agent with the receptor. Following elution, it is possible to directly determine molecular structure by passing the elute through other testing devices such as a mass spectrometer.

摘要翻译： 本发明在液相色谱系统中提供载体上的固定化受体。 本发明的方法提供了评估试剂与受体的连接的方法，包括以下步骤：（a）将受体固定在柱上的人造膜支持物上，（b）将载体与受体暴露于不同浓度的试剂 液相色谱系统，（c）从柱中洗脱测试剂，（d）评估测试材料从柱中的洗脱曲线。使用该方法，可以评估测试试剂与受体的相互作用。 洗脱后，可以通过将洗脱液通过其它测试装置如质谱仪来直接确定分子结构。

公开(公告)号：US5627329A

公开(公告)日：1997-05-06

申请号：US527609

申请日：1995-09-13

申请人： Chandrasekhar Krishnan ,  Jian S. Qi ,  Joseph A. Incavo ,  William L. Reuter ,  Vivek Jain

发明人： Chandrasekhar Krishnan ,  Jian S. Qi ,  Joseph A. Incavo ,  William L. Reuter ,  Vivek Jain

IPC分类号： G01N13/00 ,  G01N30/00 ,  G01N30/02 ,  G01N30/89 ,  G01N15/00

CPC分类号： G01N30/00 ,  G01N13/00 ,  G01N2030/025 ,  G01N30/89

摘要： Disclosed is a method of determining a diffusion coefficient for a diffusant in a particulate. An inert gas is passed through a particulate containing the diffusant. A parameter that is proportional to the concentration of the diffusant in the inert gas is measured over a period of time and the slope of the linear portion of that relationship is determined and is multiplied by a constant.

摘要翻译： 公开了一种确定微粒中扩散剂的扩散系数的方法。 惰性气体通过含有扩散剂的颗粒。 在一段时间内测量与惰性气体中的扩散剂的浓度成比例的参数，并确定该关系的线性部分的斜率并乘以常数。

公开(公告)号：US20170267934A1

公开(公告)日：2017-09-21

申请号：US15532426

申请日：2015-12-01

申请人： W. R. Grace & Co,-Conn

发明人： Dieter Wallenstein ,  Stefan Brandt

IPC分类号： C10G11/18 ,  G01N15/08 ,  G01N30/89 ,  G01N13/00

CPC分类号： C10G11/187 ,  C10G2300/708 ,  G01N13/00 ,  G01N15/082 ,  G01N30/89 ,  G01N2013/003

摘要： Process for evaluating the catalytic performance of a porous solid using a vapor diffusion technique, where a probe molecule and a molecule for dead-time determination is injected into a carrier gas that is then contacted with the porous solid in a vessel, where a detector analyzes the peak width and retention time of a probe molecule and the retention time of the molecule for dead-time determination in the gas exiting the vessel.