摘要:
The present invention relates to phenyl diamides according to the general formula (1) and their use as a medicament and a pharmaceutical preparation comprising as an active ingredient a phenyl diamide according to the general formula (1). Further, the present invention relates to phenyl diamides according to the formulas (16), (17) and (18) for use in the treatment of gliomas.
摘要:
The present invention is directed to a process for the preparation of finely dispersed, easily spreadable, aqueous polyurethane reactive coating compositions suitable for coating textile sheet products, artificial leather or leather by the direct or transfer coating process by(i) forming an aqueous dispersion having a solids content of about 20-69 wt. % of blocked isocyanate prepolymers in the presence of from about 0.05-5% by weight of emulsifiers,(ii) adding during or after formation of the dispersion about 0.1 to 2.5% by weight of water soluble thickeners based on long chain polyethylene oxides, salts of poly(meth)acrylic acids or salts of carboxy methyl cellulose, up to 100% by weight of aqueous polymer solutions and/or polymer dispersions and optionally levelling agents, pigments, fillers or stabilizers and(iii) forming a coating composition having a viscosity of from about 3000 to 22,000 mPa.s/25.degree. C. and with a solids content of about 20-69% by weight, by adding approximately equivalent quantities of (cyclo)aliphatic di- and/or polyamines.The present invention is also directed to the coating compositions prepared by this process and their use for the reactive coating of substrates, particularly textile and leather or artificial leather substrates.
摘要:
This invention relates to new liquid or fluid polyamine/carbonic acid salt compositions free from crystalline content and their preparation from mixtures containing at least one aliphatic or cycloaliphatic polyamine, an aliphatic or cycloaliphatic hydroxyamine having at least one hydroxyl group and at least one amino group, and water and optionally diluents and/or conventional auxiliary agents and additives, by the addition of carbon dioxide. The proportion of polyamine to hydroxyamine is in the range of from about 95:5 to 10:90 % by weight, the quantity of water added is from about 0.01 to 5 mol of H.sub.2 O per amine equivalent (but at least 1 mol of water per mol of CO.sub.2) and the quantity of CO.sub.2 added is from about 0.01 to 0.99 mol of CO.sub.2 per amine equivalent. The invention further relates to the use of these liquid polyamine/carbonic acid salt compositions for the production of foamed polyurethane ureas, especially for coating substrates or for the production of sheet products, using prepolymers preferably containing blocked isocyanate groups and the liquid polyamine/carbonic acid salt compositions as chain lengthening agents and/or crosslinking agents and at the same time as physiologically harmless blowing agents.
摘要:
The invention relates to a method for the automatic control of batch processes by means of a process control in which the automatic control programs access individual control modules, wherein a) the control instructions and parameter definitions contained in the partial formulations or phases of the formulation program are stored in a separate program level for the activation, interlocking and switch-on blocking of actuators in the field, b) in the separate program level, the control instructions and parameter definitions for each actuator to be activated are collected actuator by actuator and, if appropriate, logically combined, and c) the currently effective activations, interlockings and switch-on blockings are output, actuator by actuator, to the process operating and monitoring system.
摘要:
The invention relates to compounds selected from among the group comprising general formulas (1), (2), (3), and/or (4) and/or the enantiomers, diastereomers, and derivatives thereof, and the pharmaceutically acceptable salts thereof for producing a medicament used for therapeutically and/or preventively treating disease and pathological conditions linked to regulation of the insulin and/or insulin-like growth factor (IGF) signalling pathway and/or for chemically inducing longevity.
摘要:
When carrying out a method for sterile bottling of beverages, which comprises the steps of cleaning the bottles first in a cleaning station by means of lye, transporting them then to a separate filling station, filling them in said filling station with the previously sterilized beverage, and closing them finally in a closing station, the sterilization of the interior of the bottles by introducing steam and/or hot water is carried out several times successively in spatially separated stations. This fractional sterilization of the bottles achieves a very high germ destruction rate, the amount of energy consumed being low and the bottles being treated carefully. In addition, measures against a reinfection of the bottles in the area of transport between the stations can be dispensed with so that a good accessibility of the transport area is guaranteed.