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公开(公告)号：US09044347B2
公开(公告)日：2015-06-02
申请号：US13586350
申请日：2012-08-15
申请人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbanchek , Daryl R. Kipke , Sarah Richardson-Burns , David C. Martin , Eugene D. Daneshvar
发明人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbanchek , Daryl R. Kipke , Sarah Richardson-Burns , David C. Martin , Eugene D. Daneshvar
CPC分类号： A61F2/72 , A61F2250/0001 , A61L27/34 , A61L27/3675 , A61N1/05 , A61N1/0543 , A61N1/0551 , A61N1/36125
摘要： A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a way to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).
摘要翻译： 混合生物电接口（HBI）装置可以是可植入装置，其包括可操作以经由电子或离子传递电荷的非生物成分; 与神经组织接触的生物组分，生物组分来自生物学，生物衍生的或生物功能化的材料; 共轭聚合物组分一起提供了一种使活体神经组织与电子设备长期接触延长持续时间（例如大于10年）的方式。 在一些实施方案中，共轭聚合物为神经系统和电子设备（例如机器人假肢，视网膜植入物，微芯片）之间的电荷转移和信号转导提供功能性电接口。
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2.发明申请公开(公告)号：US20090198184A1
公开(公告)日：2009-08-06
申请号：US12322716
申请日：2009-02-05
IPC分类号： A61M5/00 , A61M1/00 , A61M25/14 , A61B17/60 , A61B17/58 , A61B17/70 , A61F2/82 , A61F2/18 , A61F2/60 , A61F2/54
CPC分类号： A61F2/2814 , A61B17/60 , A61B17/86 , A61F2/30749 , A61M39/0247 , A61M39/16 , A61M2039/0264
摘要： A percutaneous biomedical device comprising a body having a lumen extending longitudinally at least partially through the body, an implantable interface region disposed on the body, the implantable interface region having a plurality of radially extending conduits through the body, each of the conduits are in fluid communication with the lumen and in fluid communication with an exit port. The exit ports extrude a skin-interface composition between the subject's skin and the percutaneous biomedical device. Methods for implanting a percutaneous biomedical device includes implanting a percutaneous biomedical device percutaneously in a subject and aligning the exit ports of the implantable interface region between the epidermis and the hypodermis skin layers of the subject.
摘要翻译： 一种经皮生物医学装置，其包括具有至少部分地穿过身体纵向延伸的内腔的主体，设置在主体上的可植入界面区域，该可植入界面区域具有穿过本体的多个径向延伸的导管，每个导管处于流体 与管腔的通信并与出口端口流体连通。 出口端口挤出受试者皮肤和经皮生物医学装置之间的皮肤界面组成。 用于植入经皮生物医学装置的方法包括经皮经皮植入经皮生物医学装置并对准该受体的表皮和皮下皮肤层之间的可植入界面区域的出口。
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公开(公告)号：US20090292325A1
公开(公告)日：2009-11-26
申请号：US12432343
申请日：2009-04-29
申请人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbancheck , Daryl A. Kipke , Sarah Richardson-Burns , David C. Martin
发明人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbancheck , Daryl A. Kipke , Sarah Richardson-Burns , David C. Martin
IPC分类号： A61N1/00
CPC分类号： A61F2/72 , A61F2250/0001 , A61L27/34 , A61L27/3675 , A61N1/05 , A61N1/0543 , A61N1/0551 , A61N1/36125
摘要： A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a means to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).
摘要翻译： 混合生物电接口（HBI）装置可以是可植入装置，其包括可操作以经由电子或离子传递电荷的非生物成分; 与神经组织接触的生物组分，生物组分来自生物学，生物衍生的或生物功能化的材料; 共轭聚合物组分共同提供长寿命地将活体神经组织与电子装置接合以延长持续时间（例如大于10年）的手段。 在一些实施方案中，共轭聚合物为神经系统和电子设备（例如机器人假肢，视网膜植入物，微芯片）之间的电荷转移和信号转导提供功能性电接口。
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公开(公告)号：US20140249645A1
公开(公告)日：2014-09-04
申请号：US13586350
申请日：2012-08-15
申请人： PAUL S. CEDERNA , BRENT M. EGELAND , MOHAMMAD REZA ABIDIAN , ANTONIO PERAMO , MELANIE G. URBANCHEK , DARYL R. KIPKE , SARAH RICHARDSON-BURNS , DAVID C. MARTIN , EUGENE D. DANESHVAR
发明人： PAUL S. CEDERNA , BRENT M. EGELAND , MOHAMMAD REZA ABIDIAN , ANTONIO PERAMO , MELANIE G. URBANCHEK , DARYL R. KIPKE , SARAH RICHARDSON-BURNS , DAVID C. MARTIN , EUGENE D. DANESHVAR
CPC分类号： A61F2/72 , A61F2250/0001 , A61L27/34 , A61L27/3675 , A61N1/05 , A61N1/0543 , A61N1/0551 , A61N1/36125
摘要： A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a means to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).
摘要翻译： 混合生物电接口（HBI）装置可以是可植入装置，其包括可操作以经由电子或离子传递电荷的非生物成分; 与神经组织接触的生物组分，生物组分来自生物学，生物衍生的或生物功能化的材料; 共轭聚合物组分共同提供长寿命地将活体神经组织与电子装置接合以延长持续时间（例如大于10年）的手段。 在一些实施方案中，共轭聚合物为神经系统和电子设备（例如机器人假肢，视网膜植入物，微芯片）之间的电荷转移和信号转导提供功能性电接口。
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