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    FIBROSIS BIOMARKER ASSAY
    2.
    发明申请
    FIBROSIS BIOMARKER ASSAY 有权
    FIBROSIS BIOMARKER测定

    公开(公告)号：US20100209940A1

    公开(公告)日：2010-08-19

    申请号：US12749652

    申请日：2010-03-30

    申请人： Sanne S. Veidal ,  Morten A. Karsdal ,  Diana J. Leeming ,  Natasha Barascuk ,  Helene Skjøt-Arkil ,  Antonio Segovia-Silvestre ,  Efstathios Vassiliadis

    发明人： Sanne S. Veidal ,  Morten A. Karsdal ,  Diana J. Leeming ,  Natasha Barascuk ,  Helene Skjøt-Arkil ,  Antonio Segovia-Silvestre ,  Efstathios Vassiliadis

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  C12Q1/37 ,  G01N2333/4737 ,  G01N2333/78 ,  G01N2800/085 ,  G01N2800/32 ,  G01N2800/50

    摘要： Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

    摘要翻译： 诊断或定量纤维化的方法包括进行免疫测定以测量天然存在于生物流体样品中的含有蛋白质片段的蛋白质片段，并将所述患者中所述患者的高度高于正常水平与纤维化的存在或程度相关联。 免疫测定通过以下方法进行，该方法包括：将天然存在于所述样品中的蛋白质片段与免疫结合配偶体接触，所述免疫结合配偶体与通过蛋白酶切割蛋白质形成的新表位反应，并测量肽片段与所述免疫结合的结合程度 其中所述蛋白质是III型胶原，I型胶原，IV型胶原，V型胶原或VI型胶原蛋白，弹性蛋白，双糖链蛋白聚糖，核心蛋白聚糖，多巴胺，多聚核苷酸， 神经鞘蛋白，短纤维蛋白原，纤维调节蛋白，血清蛋白，syndecan，betaglycan，波形蛋白或C反应蛋白。

    Fibrosis Biomarker Assay
    5.
    发明申请
    Fibrosis Biomarker Assay 审中-公开
    纤维化生物标志物测定

    公开(公告)号：US20160091502A1

    公开(公告)日：2016-03-31

    申请号：US14960713

    申请日：2015-12-07

    申请人： Sanne S. Veidal ,  Morten A. Karsdal ,  Diana J. Oersnes-Leeming ,  Natasha Barascuk Michaelsen ,  Helene Skjot-Arkil ,  Antonio Segovia-Silvestre ,  Efstathios Vassiliadis

    发明人： Sanne S. Veidal ,  Morten A. Karsdal ,  Diana J. Oersnes-Leeming ,  Natasha Barascuk Michaelsen ,  Helene Skjot-Arkil ,  Antonio Segovia-Silvestre ,  Efstathios Vassiliadis

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  C12Q1/37 ,  G01N2333/4737 ,  G01N2333/78 ,  G01N2800/085 ,  G01N2800/32 ,  G01N2800/50

    摘要： Methods of diagnosis or of quantitation of fibrosis are provided that comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of the measure in the patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a contacting protein fragments naturally present in the sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to the immunological binding partner to measure therein protein fragments comprising the neo-epitope. The protein is collagen type III, collagen type I, collagen type IV, collagen type V, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

    摘要翻译： 提供了诊断或定量纤维化的方法，其包括进行免疫测定以测量天然存在于生物流体样品中的含有蛋白质片段的蛋白质片段，并将患者高于正常水平的措施的升高与存在或程度相关联 纤维化。 免疫测定通过天然存在于样品中的接触蛋白片段与免疫结合配偶体进行，所述蛋白质片段与通过蛋白酶切割蛋白质形成的新表位反应，并测量肽片段与免疫结合配偶体的结合程度以测量 其中包含新表位的蛋白质片段。 蛋白质是III型胶原，I型胶原，IV型胶原，弹性蛋白，双聚糖蛋白聚糖，核心蛋白聚糖，多西紫杉醇，多西紫杉醇，神经鞘蛋白，短纤维蛋白，纤维调节蛋白，丝氨酸蛋白酶，syndecan，betaglycan，波形蛋白或C-反应蛋白 。