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公开(公告)号：US20170176458A1
公开(公告)日：2017-06-22
申请号：US15446070
申请日：2017-03-01
申请人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
发明人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis are provided that comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of the measure in the patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a contacting protein fragments naturally present in the sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to the immunological binding partner to measure therein protein fragments comprising the neo-epitope. The protein is collagen type I, collagen type IV, collagen type V, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.
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公开(公告)号：US20160091502A1
公开(公告)日：2016-03-31
申请号：US14960713
申请日：2015-12-07
申请人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
发明人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis are provided that comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of the measure in the patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a contacting protein fragments naturally present in the sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to the immunological binding partner to measure therein protein fragments comprising the neo-epitope. The protein is collagen type III, collagen type I, collagen type IV, collagen type V, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.
摘要翻译： 提供了诊断或定量纤维化的方法，其包括进行免疫测定以测量天然存在于生物流体样品中的含有蛋白质片段的蛋白质片段，并将患者高于正常水平的措施的升高与存在或程度相关联 纤维化。 免疫测定通过天然存在于样品中的接触蛋白片段与免疫结合配偶体进行，所述蛋白质片段与通过蛋白酶切割蛋白质形成的新表位反应，并测量肽片段与免疫结合配偶体的结合程度以测量 其中包含新表位的蛋白质片段。 蛋白质是III型胶原，I型胶原，IV型胶原，弹性蛋白，双聚糖蛋白聚糖，核心蛋白聚糖，多西紫杉醇，多西紫杉醇，神经鞘蛋白，短纤维蛋白，纤维调节蛋白，丝氨酸蛋白酶，syndecan，betaglycan，波形蛋白或C-反应蛋白 。
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公开(公告)号：US09880177B2
公开(公告)日：2018-01-30
申请号：US15446070
申请日：2017-03-01
申请人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
发明人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： A method of bioassay for the quantification of biomarkers useful in the diagnosis of fibrosis disease and prognosis of its development, including biomarkers indicative of the risk of developing fibrosis after a chronic injury is provided. In particular, according to the present invention, biomarkers relating to degradation fragments of Collagen type I, III, IV, V, and VI, elastin, C-reactive protein, and proteoglycans including Biglycan, Decorin, Versican, and Perlecan are found to be useful.
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公开(公告)号：US09606130B2
公开(公告)日：2017-03-28
申请号：US14960713
申请日：2015-12-07
申请人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
发明人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Oersnes-Leeming , Natasha Barascuk Michaelsen , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Provided herein are methods of diagnosis or of quantitation of fibrosis. An immunoassay is conducted to measure neo-epitope containing protein fragments of collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein naturally present in a biofluid sample obtained from a patient. An above normal elevation of the measured protein fragments in the patient is associated with the presence or extent of fibrosis.
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公开(公告)号：US09206464B2
公开(公告)日：2015-12-08
申请号：US12749652
申请日：2010-03-30
申请人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Leeming , Natasha Barascuk , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
发明人： Sanne S. Veidal , Morten A. Karsdal , Diana J. Leeming , Natasha Barascuk , Helene Skjot-Arkil , Antonio Segovia-Silvestre , Efstathios Vassiliadis
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Provided herein are methods of diagnosis or of quantitation of fibrosis. An immunoassay is conducted to measure neo-epitope containing protein fragments of collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein naturally present in a biofluid sample obtained from a patient. An above normal elevation of the measured protein fragments in the patient is associated with the presence or extent of fibrosis.
摘要翻译： 本文提供了诊断或定量纤维化的方法。 进行免疫测定以测量含有III型胶原蛋白，I型胶原，IV型胶原，V型胶原或VI型胶原蛋白，弹性蛋白，双糖链蛋白聚糖，核心蛋白聚糖，多巴胺，多西紫杉醇，神经氨酸， 纤维调节素，丝氨酸蛋白酶，syndecan，betaglycan，波形蛋白或C反应蛋白，其天然存在于从患者获得的生物流体样品中。 患者中测量的蛋白质片段的正常升高与纤维化的存在或程度相关。
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