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1.发明申请Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals 失效法呢基二苯并二氮杂酮的磷酸酯前药，其制备方法及其作为药物的用途公开(公告)号：US20070078112A1
公开(公告)日：2007-04-05
申请号：US11527581
申请日：2006-09-27
申请人： Mustapha Aouidate , James McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun Banskota , Maxime Ranger , Gregory White
发明人： Mustapha Aouidate , James McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun Banskota , Maxime Ranger , Gregory White
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C07D243/10 , C07F9/5535
摘要： This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
摘要翻译： 本发明涉及法呢基化二苯并二氮杂酮的磷酸酯前药，其制备方法，包含前药的药物组合物及其在治疗赘生物中的用途。
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2.发明申请Polycyclic aromatics and derivatives thereof and processes for their preparation 审中-公开多环芳烃及其衍生物及其制备方法公开(公告)号：US20060106028A1
公开(公告)日：2006-05-18
申请号：US11268610
申请日：2005-11-08
申请人： James McAlpine , Arjun Banskota
发明人： James McAlpine , Arjun Banskota
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C12P17/165 , C07D401/06 , C07D401/14
摘要： This invention relates to novel biologically active polycyclic aromatics produced by cultivation of Micromonospora echinospora ssp. challisensis NRRL 12255. The invention also relates to their pharmaceutically acceptable salts, prodrugs and derivatives, and to methods of obtaining them by post-biosynthesis chemical modification. The invention further relates to the use of the polycyclic aromatics and their derivatives in the preparation of medicaments for the treatment of neoplastic conditions and bacterial infections.
摘要翻译： 本发明涉及通过种植小单孢菌（Sponomonospora echinospora ssp）生产的新型生物活性多环芳烃。 本发明还涉及其药学上可接受的盐，前药和衍生物，以及通过后生物合成化学修饰获得它们的方法。 本发明还涉及多环芳烃及其衍生物在制备用于治疗肿瘤性病症和细菌感染的药物中的用途。
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3.发明申请Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals 审中-公开二苯并二氮杂酮类似物，其制备方法及其作为药物的用途公开(公告)号：US20060079512A1
公开(公告)日：2006-04-13
申请号：US11253658
申请日：2005-10-20
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.
摘要翻译： 本发明涉及由式I表示的生物活性二苯并二氮杂酮类似物，其制备方法，包含它们的药物组合物和治疗肿瘤病症的方法。
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4.发明申请公开(公告)号：US20060079509A1
公开(公告)日：2006-04-13
申请号：US11235398
申请日：2005-09-27
IPC分类号： A61K31/551 , C07D243/10
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.
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