Abstract:
Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
Abstract:
The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
Abstract:
Textual fault messages in PLC-based manufacturing systems are supplemented by automatically displayed sets of information that allow an operator to quickly identify, recognize and visualize components responsible for producing faults. Visual display of stored computer generated images showing system components and tooling allow the operator to visually pinpoint the exact component responsible for the fault, and its location within the manufacturing system. Stored information associated with the component producing the fault, such as installation date, vendor sources, replacement part inventory, programming logic and editing software, is also automatically recalled and displayed along with the fault message to aid fault diagnosis and correction.
Abstract:
A system and method for validating data for a machine arrangement includes a controller, such as a programmable logic controller, connected to a processor, which is configured to execute an algorithm using the data collected by the controller. The algorithm includes one or more rules that are applicable to the collected data. Each rule is applied to the data to determine if any of the data entries violate one or more of the rules. An output is generated indicating whether the data violates any of the rules, thereby providing information regarding the validity of the data being captured.
Abstract:
A waste trap 10 for use in plumbing installations is provided, the trap comprising a unitary metal body 12 defining an interior volume, and having a tubular plastics insert 20 located in an inlet 14 of the body 12 and extending into the volume to below the height of a waste outlet 16. The insert 20 partitions the upper portion of the volume into two regions, and serves to provide a water seal between the inlet 14 and the outlet 16 when the trap is in use. The insert is non-removably secured to the body.
Abstract:
Described are methods and systems for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
Abstract:
3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
Abstract:
Novel polyene oxazole compounds of Formula I: are useful as cytotoxic agents. The polyene oxazoles may be made by fermentation of Streptomyces sparsogenes and optional post-biosynthesis chemical modification thereof.
Abstract:
The present invention relates to crystalline forms of ECO-4601 and the processes for providing them. The invention further relates to pharmaceutical compositions comprising the crystalline forms and to methods of use of the crystalline forms as pharmaceuticals.
Abstract:
This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.