公开(公告)号：US20080251751A1

公开(公告)日：2008-10-16

申请号：US12099889

申请日：2008-04-09

申请人： Arndt Bruckner ,  Dirk Kuppert

发明人： Arndt Bruckner ,  Dirk Kuppert

IPC分类号： A62D1/04

CPC分类号： C08G77/46 ,  A62D1/0071 ,  C08G77/392

摘要： The present invention relates to compositions having organosilicon compounds for generating foams, where the organosilicon compounds have sulphonate groups and Si—O—C linkages, and also to the use of these compositions for producing aqueous foams, in particular fire-extinguishing foams and cleaning foams.

摘要翻译： 本发明涉及具有用于生成泡沫的有机硅化合物的组合物，其中有机硅化合物具有磺酸根基团和Si-O-C键，以及这些组合物用于生产水性泡沫，特别是灭火泡沫和清洁泡沫的用途。

公开(公告)号：US20090043001A1

公开(公告)日：2009-02-12

申请号：US12187649

申请日：2008-08-07

申请人： Arndt BRUCKNER ,  Carsten Schiller ,  Christian Mund

发明人： Arndt BRUCKNER ,  Carsten Schiller ,  Christian Mund

IPC分类号： C08J9/00 ,  C07F7/08

CPC分类号： C08G77/08 ,  C08G77/10 ,  C08K5/098

摘要： The invention relates to a process for the preparation of branched siloxanes containing R—SiO3/2 units, where R=organic radical, wherein straight-chain polysiloxanes containing silane hydrogen in the polymer chain are reacted in the presence of ammonium or metal carboxylates as a catalyst in the absence of hydroxy-functional organic compounds, and to siloxanes thus prepared and the use thereof in the preparation of polyurethane foams and antifoam formulations.

摘要翻译： 本发明涉及一种制备含有R-SiO 3/2单元的支链硅氧烷的方法，其中R =有机基，其中在聚合物链中含有硅烷氢的直链聚硅氧烷在铵或金属羧酸盐存在下反应，作为 在不存在羟基官能的有机化合物的情况下的催化剂，以及由此制备的硅氧烷及其在制备聚氨酯泡沫和消泡剂配方中的用途。

公开(公告)号：US20080188651A1

公开(公告)日：2008-08-07

申请号：US12006364

申请日：2008-01-02

申请人： Dennis P. Curran ,  Youseung Shin ,  Jean-Hugues Fournier ,  John Mancuso ,  Billy W. Day ,  Arndt Bruckner ,  Yoshikazu Fukui

发明人： Dennis P. Curran ,  Youseung Shin ,  Jean-Hugues Fournier ,  John Mancuso ,  Billy W. Day ,  Arndt Bruckner ,  Yoshikazu Fukui

IPC分类号： C07D225/02 ,  C07D313/04 ,  C07C59/10

CPC分类号： C07C33/02 ,  C07B2200/07 ,  C07C59/10 ,  C07C59/42 ,  C07C69/732 ,  C07C69/734 ,  C07D309/10 ,  C07D309/30 ,  C07D313/00 ,  C07D319/06 ,  C07D407/06 ,  C07F7/1804 ,  Y02P20/55

摘要： Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediates. Dictyostatin analogs can have the following structure or its enantiomer wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; Ra, Rb and Rc are independently an alkyl group or an aryl group; Rd is an alkyl group, an aryl group, an alkoxylalkyl group, —RiSiRaRbRc or a benzyl group, wherein Ri is an alkylene group; Re is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NRgRh, wherein Rg and Rh are independently H, an alkyl group or an aryl group; R3 is (CH2)n where n is and integer in the range of 0 to 5, —CH2CH(CH3), —CH═CH—, —CH═C(CH3), or —C≡C—; R4 is wherein R23a is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe, R23b is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe, or R23a and R23b together form a portion of six-membered acetal ring incorporating CRtRu; Rt and Ru are independently H, an alkyl group, an aryl group or an alkoxyaryl group; and R5 is H or OR2b, wherein R2b is H, a protecting group, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; provided that the compound is not dictyostatin 1.

公开(公告)号：US07321046B2

公开(公告)日：2008-01-22

申请号：US11139949

申请日：2005-05-27

申请人： Dennis P. Curran ,  Youseung Shin ,  Jean-Hugues Fournier ,  John Mancuso ,  Billy W. Day ,  Arndt Bruckner ,  Yoshikazu Fukui

发明人： Dennis P. Curran ,  Youseung Shin ,  Jean-Hugues Fournier ,  John Mancuso ,  Billy W. Day ,  Arndt Bruckner ,  Yoshikazu Fukui

IPC分类号： C07D313/04 ,  C07D313/16

CPC分类号： C07C33/02 ,  C07B2200/07 ,  C07C59/10 ,  C07C59/42 ,  C07C69/732 ,  C07C69/734 ,  C07D309/10 ,  C07D309/30 ,  C07D313/00 ,  C07D319/06 ,  C07D407/06 ,  C07F7/1804 ,  Y02P20/55

摘要： Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediates. Dictyostatin analogs can have the following structure or its enantiomer wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; Ra, Rb and Rc are independently an alkyl group or an aryl group; Rd is an alkyl group, an aryl group, an alkoxylalkyl group, —RiSiRaRbRc or a benzyl group, wherein Ri is an alkylene group; Re is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NRgRh, wherein Rg and Rh are independently H, an alkyl group or an aryl group; R3 is (CH2)n where n is and integer in the range of 0 to 5, —CH2CH(CH3)—, —CH═CH—, —CH═C(CH3)—, or —C≡C—; R4 is wherein R23a is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; R23b is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe, or R23a and R23b together form a portion of six-membered acetal ring incorporating CRtRu; Rt and Ru are independently H, an alkyl group, an aryl group or an alkoxyaryl group; and R5 is H or OR2b, wherein R2b is H, a protecting group, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; provided that the compound is not dictyostatin 1.

公开(公告)号：US20060025395A1

公开(公告)日：2006-02-02

申请号：US11139949

申请日：2005-05-27

申请人： Dennis Curran ,  Youseung Shin ,  Jean-Hugues Fournier ,  John Mancuso ,  Billy Day ,  Arndt Bruckner ,  Yoshikazu Fukui

发明人： Dennis Curran ,  Youseung Shin ,  Jean-Hugues Fournier ,  John Mancuso ,  Billy Day ,  Arndt Bruckner ,  Yoshikazu Fukui

IPC分类号： A61K31/365 ,  A61K31/16 ,  A61K31/202

CPC分类号： C07C33/02 ,  C07B2200/07 ,  C07C59/10 ,  C07C59/42 ,  C07C69/732 ,  C07C69/734 ,  C07D309/10 ,  C07D309/30 ,  C07D313/00 ,  C07D319/06 ,  C07D407/06 ,  C07F7/1804 ,  Y02P20/55

摘要： Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediates. Dictyostatin analogs can have the following structure or its enantiomer wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; Ra, Rb and Rc are independently an alkyl group or an aryl group; Rd is an alkyl group, an aryl group, an alkoxylalkyl group, —RiSiRaRbRc or a benzyl group, wherein Ri is an alkylene group; Re is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NRgRh, wherein Rg and Rh are independently H, an alkyl group or an aryl group; R3 is (CH2)n where n is and integer in the range of 0 to 5, —CH2CH(CH3)—, —CH═CH—, —CH═C(CH3)—, or —C≡C—; R4 is wherein R23a is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; R23b is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe, or R23a and R23b together form a portion of six-membered acetal ring incorporating CRtRu; Rt and Ru are independently H, an alkyl group, an aryl group or an alkoxyaryl group; and R5 is H or OR2b, wherein R2b is H, a protecting group, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; provided that the compound is not dictyostatin 1.

公开(公告)号：US20090088488A1

公开(公告)日：2009-04-02

申请号：US12236778

申请日：2008-09-24

申请人： Arndt Bruckner ,  Martin Glos

发明人： Arndt Bruckner ,  Martin Glos

IPC分类号： C08J9/00

CPC分类号： C08G77/46 ,  C08G18/42 ,  C08G18/61 ,  C08G2101/0008 ,  C08G2101/0083

摘要： The invention relates to the use of a composition comprising at least one compound of the general formula (I) where R1 are identical or different, straight-chain or branched, aliphatic or aromatic, optionally halogenated, optionally unsaturated hydrocarbon radicals having 1 to 8 carbon atoms, k=0 to 10, R2 is a group of the formula A-B-D-Q, where A is an oxygen atom, a CH2 group or a CH═CH group, B is a CH2 group or a divalent radical selected from linear or branched, saturated, mono- or polyunsaturated alkyloxy, aryloxy, alkylaryloxy or arylalkyloxy groups having 2 to 20 carbon atoms or a group of the formula —CH2—O—(CH2)4—O—, D is a group of the general formula (II) (C2H4O)n(C3H6O)o(C12H24O)p(C8H8O)q(C4H8O)r—  (II) where n, o, p, q and r are mutually independent integers from 0 to 50, where the sum of the indices n+o+p+q+r is greater than or equal to 3 and the general formula II represents a statistical oligomer or a block oligomer, and Q is a radical selected from hydrogen, linear or branched, saturated, mono- or polyunsaturated alkyl, aryl, alkylaryl or arylalkyl groups having 1 to 20 carbon atoms, optionally containing one or more heteroatoms, optionally containing one or more carbonyl groups, optionally modified with an ionic organic group, in the production of polyester polyurethane foams, and to a process for producing such compositions.

摘要翻译： 本发明涉及包含至少一种通式（I）的化合物的组合物的用途，其中R 1相同或不同，具有1-8个碳原子的直链或支链，脂族或芳族，任选卤代的，任选卤代的，任选不饱和的烃基 原子，k = 0至10，R2是式ABDQ的基团，其中A是氧原子，CH2基团或CH-CH基团，B是CH2基团或选自直链或支链饱和的二价基团 ，单或多不饱和烷氧基，芳氧基，具有2〜20个碳原子的烷基芳氧基或芳基烷氧基或式-CH 2 -O-（CH 2）4 -O-的基团，D是通式（II）的基团， （C2H4O）n（C3H6O）o（C12H24O）p（C8H8O）q（C4H8O）r-（II）<？in-line -formulae description =“In-line Formulas”end =“tail”？>其中n，o，p，q和r是从0到50的相互独立的整数，其中索引n + o + p + q + r大于或等于3， 式II表示统计低聚物或嵌段低聚物，Q是选自氢，直链或支链，饱和，单或多不饱和的具有1至20个碳原子的烷基，芳基，烷基芳基或芳基烷基的基团，任选地含有一个或多个 在制备聚酯聚氨酯泡沫时，任选地含有一个或多个羰基，任选地被离子有机基团改性的杂原子，以及制备这种组合物的方法。