HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF

    公开(公告)号:US20180362697A1

    公开(公告)日:2018-12-20

    申请号:US16110194

    申请日:2018-08-23

    Applicant: Novartis AG

    Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

    CHAIN-EXTENDED POLYDIMETHYLSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF

    公开(公告)号:US20180100053A1

    公开(公告)日:2018-04-12

    申请号:US15727666

    申请日:2017-10-09

    Applicant: Novartis AG

    Abstract: The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.

    Compounds containing (meth)acrylate groups and sulfonate or sulfate groups, polymers and condensates therefrom and use of the polymers and condensates
    9.
    发明申请
    Compounds containing (meth)acrylate groups and sulfonate or sulfate groups, polymers and condensates therefrom and use of the polymers and condensates 有权
    含有(甲基)丙烯酸酯基团和磺酸盐或硫酸盐基团的化合物,聚合物和缩合物,并使用聚合物和缩合物

    公开(公告)号:US20160297901A1

    公开(公告)日:2016-10-13

    申请号:US15163700

    申请日:2016-05-25

    Abstract: A compound has at least three functionalities, including a first functionality (a) that is a sulfonate group or a sulfate group of the formula —(O)d—SO3M with d=0 or 1 and with M=hydrogen or a monovalent metal cation or a corresponding portion of a multivalent metal cation; a second functionality (b) that is a (meth)acryl residue; and a third functionality (c) that is a carboxylic acid function and/or a thioether group. When the compound is free of silicon, the sulfonate or sulfate group and the (meth)acryl residue are separated from each other by a hydrocarbon-containing residue having a carbon chain. The carbon chain is interrupted by S or NH, or the carbon chain contains a linking group, selected from C(O)NH, NHC(O), NR8C(O), NHC(O)O, NR8C(O)O, NHC(O)NH, C(O)NHC(O) and —C(O)S—, wherein R8 is alkyl or alkenyl or a (meth)acryl group.

    Abstract translation: 化合物具有至少三个官能团,其包括第一官能团(a),其为具有d = 0或1且M =氢或一价金属阳离子的式 - (O)d-SO 3 M的磺酸酯基或硫酸根基团 或多价金属阳离子的相应部分; 作为(甲基)丙烯酰基残基的第二官能团(b) 和作为羧酸官能团和/或硫醚基团的第三官能度(c)。 当化合物不含硅时,通过具有碳链的含烃残基将磺酸盐或硫酸根基团和(甲基)丙烯酰基残基彼此分离。 碳链被S或NH中断,或者碳链含有选自C(O)NH,NHC(O),NR 8 C(O),NHC(O)O,NR 8 C(O)O,NHC (O)NH,C(O)NHC(O)和-C(O)S-,其中R8是烷基或烯基或(甲基)丙烯酰基。

    Compounds containing (meth)acrylate groups and sulfonate or sulfate groups, polymers and condensates made therefrom and use of the polymers and condensates
    10.
    发明授权
    Compounds containing (meth)acrylate groups and sulfonate or sulfate groups, polymers and condensates made therefrom and use of the polymers and condensates 有权
    含有(甲基)丙烯酸酯基团和磺酸盐或硫酸盐基团的化合物,由其制备的聚合物和缩合物,并使用聚合物和缩合物

    公开(公告)号:US09353226B2

    公开(公告)日:2016-05-31

    申请号:US14122698

    申请日:2012-05-24

    Abstract: The invention relates to a compound, comprising at least three functionalities, that is (a) a sulfonate or sulfate group of the formula —(O)d—SO3M with d=0 or 1 and M=hydrogen or a monovalent metal cation or the corresponding fraction of a polyvalent metal cation, (b) a (meth)acryl group, and (c) either (c1) at least one further (meth)acryl group or an inorganically condensable group, and/or (c2) a further carboxylic acid function, and/or (c3) a function which increases the refractive index of a material produced from the compounds, that is a thioether group, with the proviso that a sulfonate or sulfate group and a (meth)acrylate group are separated from one another in a silicon-free compound via a hydrocarbon-containing group, the carbon chain of which is either interrupted by O, S or NH or contains a linking group.

    Abstract translation: 本发明涉及包含至少三个官能团的化合物,其是(a)具有d = 0或1且M =氢或一价金属阳离子的式 - (O)d-SO 3 M的磺酸盐或硫酸根基团或 多个金属阳离子的相应部分,(b)(甲基)丙烯酰基,和(c)(c1)至少一个其它(甲基)丙烯酰基或无机缩合基团,和/或(c2) 酸性功能和/或(c3)增加由化合物(即硫醚基)生成的材料的折射率的函数,条件是磺酸根或硫酸根基和(甲基)丙烯酸酯基与一个 另一种通过含烃基团的无硅化合物,其碳链被O,S或NH中断或含有连接基团。

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