公开(公告)号：US06358718B1

公开(公告)日：2002-03-19

申请号：US09538871

申请日：2000-03-30

申请人： Mark Olson ,  Atilla Szebeni

发明人： Mark Olson ,  Atilla Szebeni

IPC分类号： C12N996

CPC分类号： C12N9/96

摘要： The present invention provides methods for stabilizing proteins, preventing protein aggregation, renaturation of previously-denatured proteins, reactivating a protein that has been inactivated by denaturation, preserving enzyme activities under conditions of elevated temperatures, inducing thermotolerance in bacteria, increasing the temperature optimum for the activity of an enzyme, and preventing formation of inclusion bodies by bacterially-expressed recombinant proteins.

摘要翻译： 本发明提供了稳定蛋白质的方法，防止蛋白质聚集，先前变性蛋白质的复性，使已变性失活的蛋白质再活化，在升高的温度条件下保存酶活性，诱导细菌耐热性，增加最佳的温度 酶的活性，并且通过细菌表达的重组蛋白阻止包涵体的形成。