公开(公告)号：US20070160585A1

公开(公告)日：2007-07-12

申请号：US10594887

申请日：2005-03-30

申请人： Kei Fujinaga ,  Morikazu Shinagawa ,  Yoshiro Niitsu ,  Hirofumi Hamada ,  Motohiro Horiuchi ,  Osamu Honmou ,  Atsushi Umetani

发明人： Kei Fujinaga ,  Morikazu Shinagawa ,  Yoshiro Niitsu ,  Hirofumi Hamada ,  Motohiro Horiuchi ,  Osamu Honmou ,  Atsushi Umetani

IPC分类号： A61K48/00 ,  A61K39/395 ,  C12N5/08 ,  C07K16/40

CPC分类号： C12N5/0669 ,  A61K35/28 ,  A61K2035/124 ,  A61K2039/505 ,  C07K16/2872 ,  C12N2510/00 ,  C12N2510/02

摘要： It is intended to provide a drug which is efficacious in treating a prion disease and has a high safety. A remedy for a prion disease which contains a mesenchymal stem cell as the active ingredient and a method of producing the same. A remedy for a prion disease which contains a mesenchymal stem cell, in particular, a mesenchymal stem cell having an anti-prion antibody gene transferred thereinto as the active ingredient and a method of producing the same. These remedies can not only prevent the progress of a prion disease but also contribute to the recovery of nerve dysfunction caused by the disease.

摘要翻译： 旨在提供一种有效治疗朊病毒疾病并具有高安全性的药物。 含有间充质干细胞作为活性成分的朊病毒病的补救方法及其制造方法。 含有间充质干细胞，特别是转移有抗朊病毒抗体基因作为活性成分的间充质干细胞的朊病毒疾病的补救方法及其制造方法。 这些补救措施不仅可以预防朊病毒疾病的进展，而且有助于疾病引起的神经功能障碍的恢复。

公开(公告)号：US5460781A

公开(公告)日：1995-10-24

申请号：US669079

申请日：1991-03-12

申请人： Hironobu Hori ,  Norigi Kurihara ,  Mitsushi Gotanda ,  Takayuki Yanagiya ,  Atsushi Umetani

发明人： Hironobu Hori ,  Norigi Kurihara ,  Mitsushi Gotanda ,  Takayuki Yanagiya ,  Atsushi Umetani

IPC分类号： B01L3/00

CPC分类号： B01L3/5029 ,  B01L2400/0406 ,  B01L3/5023 ,  Y10S436/81

摘要： A hemoglobin sampler for use with stool samples for clinical tests and diagnoses of the digestive tract diseases in mass screening, etc. by securely sampling and collecting occult hemoglobin with water content from the stool samples without being hindered by the undigested solid content of stools. The sampler has a core member consisting of a porous fiber bundle made up of a plural number of synthetic fibers bundled in the longitudinal direction thereof, a rod of a suitable length provided with a thermosetting synthetic resin sheath at the outer periphery of the core, one end of the rod forming a sample absorbing member with a suitable surface area and small diameter made up of the above mentioned porous fiber bundle. The sampler can quantitatively sample occult hemoglobin with water from stool samples of various properties, thereby offering an easy sample method for the subject and stable specimen for tests. Thus, the utility of the test method can be fully exerted and the sampler is quite useful for clinical tests and mass health screening.

摘要翻译： 用于粪便样品的血红蛋白取样器用于临床测试和大规模筛查中的消化道疾病的诊断，通过从粪便样品中安全地采集和收集含水量的隐血红蛋白，而不受未消化的粪便固体含量的阻碍。 取样器具有由多根纤维束构成的芯构件，该多孔纤维束由沿其长度方向捆扎的多根合成纤维构成，在芯的外周设置有热固性合成树脂护套的适当长度的杆， 杆的端部形成具有由上述多孔纤维束组成的合适的表面积和小直径的样品吸收构件。 取样器可以从各种性质的粪便样品中用水定量取样血红蛋白，从而为受试者提供简单的样品方法和稳定的试样。 因此，可以充分发挥试验方法的实用性，采样器对于临床试验和大规模健康检查非常有用。

公开(公告)号：US06432633B1

公开(公告)日：2002-08-13

申请号：US09621625

申请日：2000-07-21

申请人： Katsuhiko Yamamoto ,  Akemi Yoshiki ,  Toshio Matsui ,  Atsushi Umetani

发明人： Katsuhiko Yamamoto ,  Akemi Yoshiki ,  Toshio Matsui ,  Atsushi Umetani

IPC分类号： C12Q170

CPC分类号： G01N33/56988 ,  G01N33/54306

摘要： An immunoassay method of the HIV-1p24 antigen by sandwich method, using at least one polyclonal antibody recognizing the HIV-1p24 antigen and at least two monoclonal antibodies recognizing the HIV-1p24 antigen, is provided together with a reagent therefor, to establish more highly sensitive assay of the HIV-1p24 antigen than conventionally.

摘要翻译： 使用至少一种识别HIV-1p24抗原的多克隆抗体和至少两种识别HIV-1p24抗原的单克隆抗体通过夹心法进行HIV-1p24抗原的免疫测定方法与其试剂一起提供，以建立更高的 HIV-1p24抗原的敏感性测定。

公开(公告)号：US20100081845A1

公开(公告)日：2010-04-01

申请号：US11993821

申请日：2006-06-20

申请人： Teruaki Sugiyama ,  Akinori Fujishima ,  Atsushi Umetani ,  Nobutaka Matsunaga ,  Yoshiyuki Omori ,  Norihiko Seko

发明人： Teruaki Sugiyama ,  Akinori Fujishima ,  Atsushi Umetani ,  Nobutaka Matsunaga ,  Yoshiyuki Omori ,  Norihiko Seko

IPC分类号： C07C221/00

CPC分类号： C07B55/00 ,  C07B57/00 ,  C07C221/00 ,  C07C225/16

摘要： A benzylamine derivative has a structure represented by the following formula (1): In a method for optical resolution of the benzylamine derivative, optically active mandelic acid is used as an optical resolving agent. In an optical resolution step in a production method of the optically active benzylamine derivative, an optically active (S)-benzylamine derivative represented by the formula (3) is precipitated as (S)-mandelic acid salt from a solution containing the benzylamine derivative and (S)-mandelic acid: wherein Ar represents an aryl group that has 6 to 15 carbon atoms and may have a substituent, and *1 represents an asymmetric carbon atom.

摘要翻译： 苄胺衍生物具有由下式（1）表示的结构：在用于光学拆分苄胺衍生物的方法中，使用光学活性扁桃酸作为光学拆分剂。 在光学活性苄胺衍生物的制造方法中的光学拆分工序中，将由式（3）表示的光学活性（S） - 苄基胺衍生物从含有苄胺衍生物的溶液中析出为（S） - 扁桃酸盐， （S） - 扁桃酸：其中Ar表示具有6至15个碳原子并可以具有取代基的芳基，* 1表示不对称碳原子。

公开(公告)号：US20070184484A1

公开(公告)日：2007-08-09

申请号：US10512981

申请日：2002-10-31

申请人： Morikazu Shinagawa ,  Motohiro Horiuchi ,  Atsushi Umetani

发明人： Morikazu Shinagawa ,  Motohiro Horiuchi ,  Atsushi Umetani

IPC分类号： G01N33/53 ,  C12N5/06 ,  C07K16/40

CPC分类号： C07K16/2872 ,  G01N33/6896

摘要： A monoclonal antibody which recognizes abnormal type prion protein alone is disclosed. By the present invention, an anti-abnormal type prion monoclonal antibody whose corresponding antigen is an abnormal type prion protein, and which does not substantially react with normal type prion protein was first provided. Since the corresponding antigen of the monoclonal antibody according to the present invention is the naturally occurring abnormal type prion protein, measurement of the abnormal type prion protein may be attained with high sensitivity.

摘要翻译： 公开了单独鉴定异型朊病毒蛋白的单克隆抗体。 通过本发明，首先提供了相应的抗原是异常型朊病毒蛋白并且基本上不与正常型朊病毒蛋白反应的抗异常型朊病毒单克隆抗体。 由于根据本发明的单克隆抗体的相应抗原是天然存在的异常型朊病毒蛋白，所以可以以高灵敏度测定异常型朊病毒蛋白。