公开(公告)号：US20220205044A1

公开(公告)日：2022-06-30

申请号：US17584701

申请日：2022-01-26

申请人： Avellino Co., Ltd.

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/6883 ,  C12Q1/686

摘要： The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.

公开(公告)号：US11268146B2

公开(公告)日：2022-03-08

申请号：US15947473

申请日：2018-04-06

申请人： Avellino Co., Ltd.

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/6883 ,  C12Q1/686

摘要： The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.

公开(公告)号：US20150093751A1

公开(公告)日：2015-04-02

申请号：US14454669

申请日：2014-08-07

申请人： Avellino Co., Ltd.

发明人： Gene LEE ,  Jung Kuk YUN

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/686 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2561/113

摘要： The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.

摘要翻译： 本发明涉及用于诊断Avellino角膜营养不良的实时PCR引物对和探针，更具体地涉及用于诊断Avellino角膜营养不良的实时PCR引物对和探针，其可以准确地诊断突变的存在或不存在 在BIGH3基因的外显子4中，其负责Avellino角膜营养不良症。 根据本发明的引物对和探针的使用可以比使用DNA芯片或PCR的常规方法更快速和准确地诊断Avellino角膜营养不良症。

公开(公告)号：US20180274034A1

公开(公告)日：2018-09-27

申请号：US15947473

申请日：2018-04-06

申请人： Avellino Co., Ltd.

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/6883 ,  C12Q1/686

CPC分类号： C12Q1/6883 ,  C12Q1/686 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2561/113

摘要： The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.

公开(公告)号：US20180251816A1

公开(公告)日：2018-09-06

申请号：US15947463

申请日：2018-04-06

申请人： Avellino Co., Ltd.

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/686 ,  C12Q1/6883

CPC分类号： C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to a system for diagnosing Avellino corneal dystrophy, and more particularly to a system for diagnosing Avellino corneal dystrophy, in which whether a sample is normal or Avellino corneal dystrophy is determined based on the ratio of the input first PGR amplification value and the second PGR amplification value. The system makes it possible to diagnosis Avellino corneal dystrophy in a simpler and accurate manner without being influenced by the doctor's skill. Particularly, the inventive system makes the overall process systematic, and thus provides accurate diagnosis. In addition, the system can also easily administer a number of test subjects.

公开(公告)号：US20150100338A1

公开(公告)日：2015-04-09

申请号：US14472325

申请日：2014-08-28

申请人： Avellino Co., Ltd

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： G06F19/00

CPC分类号： G06F19/3418 ,  G16H10/20

摘要： A portable electronic device with a touch-sensitive display launches a software application configured for requesting a diagnostic test for Avellino corneal dystrophy and checking a result of the diagnostic test for Avellino corneal dystrophy. The device logs in to the software application. Subsequent to logging into the software application, the device displays a request form for a diagnostic test for Avellino corneal dystrophy on the touch-sensitive display. While displaying the request form, the device receives a signature at a location on the touch-sensitive display that corresponds to a signature block of the displayed request form. In response to receiving the signature, the device stores the signature for the request form as an electronic file in the memory. The device transmits the signed request form to a server computer that is located remotely from the portable electronic device.

摘要翻译： 具有触敏显示器的便携式电子设备启动配置用于请求Avellino角膜营养不良诊断测试并检查Avellino角膜营养不良诊断测试结果的软件应用。 设备登录到软件应用程序。 在登录软件应用程序之后，设备将在触敏显示屏上显示Avellino角膜营养不良诊断测试的请求表单。 在显示请求表单的同时，设备在对应于所显示的请求表单的签名块的触敏显示器上的位置处接收签名。 响应于接收到签名，设备将请求表单的签名作为电子文件存储在存储器中。 设备将签名的请求表格发送到远离便携式电子设备的服务器计算机。

公开(公告)号：US09938581B2

公开(公告)日：2018-04-10

申请号：US14454669

申请日：2014-08-07

申请人： Avellino Co., Ltd.

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q1/686 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2561/113

摘要： The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.