公开(公告)号：US20060142257A1

公开(公告)日：2006-06-29

申请号：US11356012

申请日：2006-02-17

申请人： Eberhard Nieschlag ,  Axel Kamischke ,  Michael Oettel ,  Alexander Ruebig ,  Ekkerhard Schillinger ,  Ursula-Friederike Habenicht

发明人： Eberhard Nieschlag ,  Axel Kamischke ,  Michael Oettel ,  Alexander Ruebig ,  Ekkerhard Schillinger ,  Ursula-Friederike Habenicht

IPC分类号： A61K31/56

CPC分类号： A61K31/56

摘要： A formulation for male contraception comprising a progestin possessing both estrogenic and androgenic properties is remarkably effective for spermatogenesis suppression in males. The progestin Norethisterone (NET), particularly its derivatives Norethisterone acetate and Norethisterone enanthate in sufficient doses induce oligozoospermia or azoospermia in males. Formulations further comprising an androgen, such as a testosterone derivative such as a testosterone ester, particularly testosterone undecanoate, are especially effective male contraceptive formulations.

公开(公告)号：US07025979B2

公开(公告)日：2006-04-11

申请号：US09764149

申请日：2001-01-19

申请人： Eberhard Nieschlag ,  Axel Kamischke ,  Michael Oettel ,  Alexander Ruebig ,  Ekkerhard Schillinger ,  Ursula-Friederike Habenicht

发明人： Eberhard Nieschlag ,  Axel Kamischke ,  Michael Oettel ,  Alexander Ruebig ,  Ekkerhard Schillinger ,  Ursula-Friederike Habenicht

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K9/70 ,  A61K31/56

CPC分类号： A61K31/568 ,  A61K31/569 ,  A61K2300/00

摘要： A formulation for male contraception comprising a progestin possessing both estrogenic and androgenic properties is remarkably effective for spermatogenesis suppression in males. The progestin Norethisterone (NET), particularly its derivatives Norethisterone acetate and Norethisterone enanthate in sufficient doses induce oligozoospermia or azoospermia in males. Formulations further comprising an androgen, such as a testosterone derivative such as a testosterone ester, particularly testosterone undecanoate, are especially effective male contraceptive formulations.