公开(公告)号：US09932579B2

公开(公告)日：2018-04-03

申请号：US14474205

申请日：2014-09-01

Applicant: Beeologics Inc.

Inventor： Nitzan Paldi ,  Eitan Glick

IPC: C12N15/11 ,  C07H21/02 ,  A01K51/00 ,  C12N15/113 ,  A61K31/00 ,  A61K31/7088 ,  A61D7/00

CPC classification number: C12N15/113 ,  A61D7/00 ,  A61K31/00 ,  A61K31/7088 ,  C12N2310/11 ,  C12N2310/14

Abstract: Compositions and methods for reducing susceptibility and enhancing tolerance to Nosema disease (Nosemosis) using RNA interference technology, and more particularly, prevention and treatment of Nosema infections in honeybees by feeding of Nosema-specific dsRNA.

公开(公告)号：US20150159156A1

公开(公告)日：2015-06-11

申请号：US14532596

申请日：2014-11-04

Applicant: Monsanto Technology LLC ,  Beeologics Inc. ,  The United States of America, as represented by the Secretary of Agriculture

Inventor： Alex Inberg ,  Mahak Kapoor ,  Jay Evans

IPC: C12N15/113 ,  A61K31/713 ,  A01K51/00

CPC classification number: C12N15/113 ,  A01K51/00 ,  A01N37/46 ,  A01N63/02 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/531

Abstract: This application provides and discloses anti-parasitic, anti-pest or insecticidal nucleic acid molecules and their calmodulin target genes for the control of arthropod parasites and pests. This application further provides methods and compositions for the control and treatment of parasites and pests in Apis mellifera (honey bee) hives.

Abstract translation: 本申请提供并公开了用于控制节肢动物寄生虫和害虫的抗寄生虫，抗病虫害或杀虫剂核酸分子及其钙调蛋白靶基因。 本申请还提供了用于控制和处理Apis mellifera（蜂蜜蜂）蜂巢中的寄生虫和害虫的方法和组合物。

公开(公告)号：US10927374B2

公开(公告)日：2021-02-23

申请号：US16125048

申请日：2018-09-07

Applicant: Monsanto Technology LLC ,  Beeologics, Inc. ,  The United States of America, as represented by the Secretary of Agriculture

Inventor： Alex Inberg ,  Mahak Kapoor ,  Jay Evans

IPC: C12N15/113 ,  A61K31/713 ,  A01K51/00 ,  A01N37/46 ,  A01N63/10

Abstract: This application provides and discloses anti-parasitic, anti-pest or insecticidal nucleic acid molecules and their calmodulin target genes for the control of arthropod parasites and pests. This application further provides methods and compositions for the control and treatment of parasites and pests in Apis mellifera (honey bee) hives.

公开(公告)号：US10801028B2

公开(公告)日：2020-10-13

申请号：US15498008

申请日：2017-04-26

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Beeologics, Inc.

Inventor： Ilan Sela ,  Sharoni Shafir ,  Eyal Maori ,  Yael Garbian ,  Eyal Ben-Chanoch ,  Gal Yarden ,  Haim Kalev

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/713 ,  A23K20/147 ,  A23K20/163 ,  A23K50/90 ,  A23K20/10

Abstract: An isolated nucleic acid agent is disclosed comprising a nucleic acid sequence which downregulates expression of a gene product of a Varroa destructor mite. Compositions comprising same and uses thereof are also disclosed.

公开(公告)号：US20150133532A1

公开(公告)日：2015-05-14

申请号：US14606328

申请日：2015-01-27

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Beeologics Inc.

Inventor： Ilan Sela ,  Sharoni Shafir ,  Eyal Maori ,  Yael Garbian ,  Eyal Ben-Chanoch ,  Gal Yarden ,  Haim Kalev

IPC: A61K31/713

CPC classification number: C12N15/1137 ,  A23K20/10 ,  A23K20/147 ,  A23K20/163 ,  A23K50/90 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14

Abstract: An isolated nucleic acid agent is disclosed comprising a nucleic acid sequence which downregulates expression of a gene product of a Varroa destructor mite. Compositions comprising same and uses thereof are also disclosed.

Abstract translation: 公开了一种分离的核酸试剂，其包含下调Varroa破坏螨基因产物表达的核酸序列。 还公开了包含其的组合物及其用途。

公开(公告)号：US10888579B2

公开(公告)日：2021-01-12

申请号：US13932051

申请日：2013-07-01

Applicant: Beeologics Inc.

Inventor： Nitzan Paldi ,  Gal Yarden

IPC: C12N15/11 ,  A61K31/713 ,  C12N15/113

Abstract: Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.

公开(公告)号：US10557138B2

公开(公告)日：2020-02-11

申请号：US15103685

申请日：2014-12-09

Applicant: Beeologics, Inc.

Inventor： Merav Gleit-Kielmanowicz ,  Yael Golani

IPC: C12N15/113 ,  C12N5/00

Abstract: Compositions and methods for providing viral control in Varroa mites and bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in Varroa mites and bees by providing trigger polynucleotides targeting viral sequences is disclosed.

公开(公告)号：US09662348B2

公开(公告)日：2017-05-30

申请号：US14606328

申请日：2015-01-27

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Beeologics Inc.

Inventor： Ilan Sela ,  Sharoni Shafir ,  Eyal Maori ,  Yael Garbian ,  Eyal Ben-Chanoch ,  Gal Yarden ,  Haim Kalev

IPC: C12N15/11 ,  A61K31/713 ,  C12N15/113

CPC classification number: C12N15/1137 ,  A23K20/10 ,  A23K20/147 ,  A23K20/163 ,  A23K50/90 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14

Abstract: An isolated nucleic acid agent is disclosed comprising a nucleic acid sequence which downregulates expression of a gene product of a Varroa destructor mite. Compositions comprising same and uses thereof are also disclosed.

公开(公告)号：US20130289097A1

公开(公告)日：2013-10-31

申请号：US13932051

申请日：2013-07-01

Applicant: Beeologics Inc.

Inventor： Nitzan PALDI ,  Gal Yarden

IPC: A61K31/713

CPC classification number: A61K31/713 ,  C12N15/113 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2770/22022

Abstract: Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.

Abstract translation: 使用RNA干扰技术降低蜜蜂感染性疾病的易感性的组合物和方法，更具体地，通过喂养病原体特异性dsRNA，预防和治疗诸如以色列急性麻痹病毒（IAPV）的蜜蜂中的病毒感染。 此外，公开了多病原体特异性dsRNA。

公开(公告)号：US20210275566A1

公开(公告)日：2021-09-09

申请号：US17134483

申请日：2020-12-27

Applicant: BEEOLOGICS, INC.

Inventor： Nitzan PALDI ,  Gal YARDEN

IPC: A61K31/713 ,  C12N15/113

Abstract: Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.