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1.发明申请COMPOSITIONS FOR CONFERRING TOLERANCE TO VIRAL DISEASE IN SOCIAL INSECTS, AND THE USE THEREOF 审中-公开承认社会事业中的病毒容忍的组成及其使用公开(公告)号：US20130289097A1
公开(公告)日：2013-10-31
申请号：US13932051
申请日：2013-07-01
申请人： Beeologics Inc.
发明人： Nitzan PALDI , Gal Yarden
IPC分类号： A61K31/713
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
摘要翻译： 使用RNA干扰技术降低蜜蜂感染性疾病的易感性的组合物和方法，更具体地，通过喂养病原体特异性dsRNA，预防和治疗诸如以色列急性麻痹病毒（IAPV）的蜜蜂中的病毒感染。 此外，公开了多病原体特异性dsRNA。
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2.发明申请Compositions for conferring tolerance to viral disease in social insects, and the use thereof 有权赋予社会昆虫病毒性疾病耐受性的组合物及其用途公开(公告)号：US20090118214A1
公开(公告)日：2009-05-07
申请号：US12222949
申请日：2008-08-20
申请人： Nitzan Paldi , Gal Yarden
发明人： Nitzan Paldi , Gal Yarden
IPC分类号： A61K31/713 , C07H21/02 , A61P31/12
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
摘要翻译： 使用RNA干扰技术降低对蜜蜂感染性疾病的敏感性的组合物和方法，更具体地，通过饲喂病原体特异性dsRNA来预防和治疗蜜蜂如以色列急性麻痹病毒（IAPV）中的病毒感染。 此外，公开了多病原体特异性dsRNA。
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3.发明申请SYNTHETIC REPLIKIN PEPTIDES AGAINST PATHOGENIC INFECTION OF INVERTEBRATES IN AQUACULTURE 审中-公开合成替代品抗逆转录病毒感染病原菌公开(公告)号：US20090041795A1
公开(公告)日：2009-02-12
申请号：US12108458
申请日：2008-04-23
CPC分类号： A61K39/125 , A61K38/08 , A61K38/10 , A61K38/162 , A61K39/00 , A61K39/12 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/72 , C12N2710/18022 , C12N2760/16022 , C12N2770/22022 , C12N2770/24122 , C12N2770/32022 , C12N2770/32034
摘要： The present invention provides isolated or synthesized peptides of about 7 to about 50 amino acids identified in the genome of pathogens in invertebrates in aquaculture for prevention and treatment of outbreaks of these pathogens in aquaculture and methods of preventing and treating pathogenic outbreaks using the identified peptides.
摘要翻译： 本发明提供在水产养殖中无脊椎动物病原体基因组中鉴定的约7至约50个氨基酸的分离或合成的肽，用于预防和治疗水产养殖中这些病原体的爆发以及使用鉴定的肽预防和治疗致病性爆发的方法。
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4.发明申请Composition to be administered to a living being and method for marking agents 审中-公开对生物体施用的组合物和用于标记药剂的方法公开(公告)号：US20060222662A1
公开(公告)日：2006-10-05
申请号：US10546031
申请日：2004-02-17
CPC分类号： C07K14/005 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C12N2770/22022
摘要： The invention relates to compositions to be administered to a living being, a method for marking agents that are administered to living beings, the use thereof, and an accelerated test.
摘要翻译： 本发明涉及给予生物体的组合物，对生物施用的标记剂的方法，其用途和加速试验。
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公开(公告)号：US20040166486A1
公开(公告)日：2004-08-26
申请号：US10088750
申请日：2002-03-20
IPC分类号： C12Q001/70 , C07H021/04 , C12N015/86
CPC分类号： C07K14/005 , C12N15/11 , C12N15/63 , C12N15/67 , C12N15/86 , C12N2770/22022 , C12N2770/22023 , C12N2840/203 , C12N2840/55
摘要： The present invention was conceived from the findings; that a specific higher-order structure can be formed in CrP-like viruses; that linkage of a gene reading frame downstream in the higher-order structure permits initiating the translation of a protein from various amino acids; and that a change in the combination of base pairs involved in the formation of the higher-order structure immediately upstream in the translation initiation site permits initiating the synthesis of any protein from any codon.
摘要翻译： 本发明是根据发现构想的; 可以在CrP样病毒中形成特定的高级结构; 在较高级结构下游的基因阅读框架的连接允许启动来自各种氨基酸的蛋白质的翻译; 并且在翻译起始位点的紧邻上游的参与形成高级结构的碱基对的组合的变化允许从任何密码子开始合成任何蛋白质。
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6.发明授权Synthetic replikin peptides against pathogenic infection of invertebrates in aquaculture 有权针对水产养殖中无脊椎动物感染的合成复制素肽公开(公告)号：US09408902B2
公开(公告)日：2016-08-09
申请号：US12108458
申请日：2008-04-23
IPC分类号： A61K39/12 , A61K39/125 , C07K14/72 , C07K14/005 , A61K39/00
CPC分类号： A61K39/125 , A61K38/08 , A61K38/10 , A61K38/162 , A61K39/00 , A61K39/12 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/72 , C12N2710/18022 , C12N2760/16022 , C12N2770/22022 , C12N2770/24122 , C12N2770/32022 , C12N2770/32034
摘要： The present invention provides isolated or synthesized peptides of about 7 to about 50 amino acids identified in the genome of pathogens in invertebrates in aquaculture for prevention and treatment of outbreaks of these pathogens in aquaculture and methods of preventing and treating pathogenic outbreaks using the identified peptides.
摘要翻译： 本发明提供在水产养殖中无脊椎动物病原体基因组中鉴定的约7至约50个氨基酸的分离或合成的肽，用于预防和治疗水产养殖中这些病原体的爆发以及使用鉴定的肽预防和治疗致病性爆发的方法。
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7.发明申请公开(公告)号：US20120108497A1
公开(公告)日：2012-05-03
申请号：US13332430
申请日：2011-12-21
申请人： Nitzan PALDI , Gal Yarden
发明人： Nitzan PALDI , Gal Yarden
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
摘要翻译： 使用RNA干扰技术降低蜜蜂感染性疾病的易感性的组合物和方法，更具体地，通过喂养病原体特异性dsRNA，预防和治疗诸如以色列急性麻痹病毒（IAPV）的蜜蜂中的病毒感染。 此外，公开了多病原体特异性dsRNA。
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8.发明授权Compositions for conferring tolerance to viral disease in social insects, and the use thereof 有权赋予社会昆虫病毒性疾病耐受性的组合物及其用途公开(公告)号：US08097712B2
公开(公告)日：2012-01-17
申请号：US12222949
申请日：2008-08-20
申请人： Nitzan Paldi , Gal Yarden
发明人： Nitzan Paldi , Gal Yarden
IPC分类号： C12N15/11 , C12N15/113 , C07H21/02
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
摘要翻译： 使用RNA干扰技术降低蜜蜂感染性疾病的易感性的组合物和方法，更具体地，通过喂养病原体特异性dsRNA，预防和治疗诸如以色列急性麻痹病毒（IAPV）的蜜蜂中的病毒感染。 此外，公开了多病原体特异性dsRNA。
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9.发明申请Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies 有权针对犬病理学的多核苷酸疫苗配方，特别是呼吸道和消化道病理学公开(公告)号：US20030133947A1
公开(公告)日：2003-07-17
申请号：US10211502
申请日：2002-08-02
IPC分类号： C12Q001/68 , C12P021/06 , A61K039/12 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74
CPC分类号： C07K14/005 , A61K39/0225 , A61K39/12 , A61K2039/51 , A61K2039/53 , A61K2039/54 , A61K2039/552 , A61K2039/70 , C12N2710/16722 , C12N2710/16734 , C12N2750/14322 , C12N2750/14334 , C12N2760/18434 , C12N2760/20122 , C12N2760/20134 , C12N2770/20034 , C12N2770/22022 , C12N2770/22034
摘要： Disclosed is an immunological or vaccine composition that includes at least one plasmid that contains and expresses in vivo in host canine cells a nucleic acid molecule that encodes an antigen of a canine pathogen, such as rabies G. The plasmid can include more that one nucleic acid molecule such that the plasmid can express more than one antigen. Also disclosed are methods for using and kits employing such compositions.
摘要翻译： 公开了一种免疫学或疫苗组合物，其包含至少一种在宿主犬细胞中体内含有并在体内表达编码犬病原体抗原（例如狂犬病G）的核酸分子的质粒。该质粒可以包含更多的一种核酸 分子，使得质粒可以表达多于一种的抗原。 还公开了使用这些组合物的方法和试剂盒。
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10.发明授权公开(公告)号：US08507457B2
公开(公告)日：2013-08-13
申请号：US13332430
申请日：2011-12-21
申请人： Nitzan Paldi , Gal Yarden
发明人： Nitzan Paldi , Gal Yarden
IPC分类号： C12N15/11 , C12N15/113 , C07H21/02
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
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