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1.发明授权公开(公告)号：US12121564B2
公开(公告)日：2024-10-22
申请号：US16604378
申请日：2018-03-16
申请人： BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS , Evangelos Andreakos , Maria Salagianni
IPC分类号： A61K38/21 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/10 , A61K38/00 , C07K14/555 , C07K14/57
CPC分类号： A61K38/21 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/10 , A61K38/00 , C07K14/555 , C07K14/57
摘要： The invention relates to the field of treatment or prevention of obesity-related disorders, atherosclerosis or a coagulation disorder. In particular, the present invention relates to the use of an activator of IFNλ receptor for the treatment or prevention of such disorders or conditions, and corresponding methods of treatment.
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公开(公告)号：US11536724B2
公开(公告)日：2022-12-27
申请号：US16065663
申请日：2016-12-23
申请人： Polyquant GmbH , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS , LUXEMBOURG INSTITUTE OF HEALTH , INSTITUT CURIE , ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS , FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III, CNIO
发明人： Jerome Garin , Christophe Masselon , Antonia Vlahou , Manousos Makrydakis , Ieronimos Zoidakis , Bruno Domon , Elodie Duriez , Aurelie Kamoun , Francois Radvanyi , Yves Allory , Nuria Malats Riera , Mirari Marquez Cid , Magali Court
摘要： The invention relates to a collection of signature peptides representing at least 10 proteins for use in cancer diagnosis and/or prognosis, to an artificial protein comprising signature peptides representing at least 10 proteins and to a nucleic acid construct encoding for such an artificial protein. The invention further relates to a collection of at least 10 proteins for use in cancer diagnosis and/or prognosis. Additionally, the invention relates to a method for cancer diagnosis and/or prognosis comprising the step of analyzing at least 10 proteins in a urine sample of a subject. Finally, the invention relates to an immunoassay product comprising antibodies for detecting at least 10 proteins.
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3.发明申请公开(公告)号：US20200157167A1
公开(公告)日：2020-05-21
申请号：US16604378
申请日：2018-03-16
申请人： Evangelos ANDREAKOS , Maria SALAGIANNI , BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS
摘要： The invention relates to the field of treatment or prevention of obesity-related disorders, atherosclerosis or a coagulation disorder. In particular, the present invention relates to the use of an activator of IFNλ receptor for the treatment or prevention of such disorders or conditions, and corresponding methods of treatment.
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公开(公告)号：US20150216803A1
公开(公告)日：2015-08-06
申请号：US14425830
申请日：2013-09-05
IPC分类号： A61K9/127 , C12N15/113
CPC分类号： A61K9/1274 , A61K9/127 , C12N15/113 , C12N2310/14
摘要： The present invention relates to lipid assemblies, compositions, and liposomal delivery systems comprising single chain anionic lipids, and the use thereof in diagnosis and therapy. It involves the use of anionic lysolipids for modifying the surface charge of a cationic lipid composition consisting at least one type of cationic lipid, optionally in combination with one or more neutral lipids and/or one or more anionic lipids.
摘要翻译： 本发明涉及包含单链阴离子脂质的脂质组合物，组合物和脂质体递送系统及其在诊断和治疗中的用途。 它涉及使用阴离子溶脂剂来修饰由至少一种类型的阳离子脂质组成的阳离子脂质组合物的表面电荷，任选地与一种或多种中性脂质和/或一种或多种阴离子脂质组合。
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公开(公告)号：US20210246120A1
公开(公告)日：2021-08-12
申请号：US17271119
申请日：2019-08-23
申请人： Zoe COURNIA , Anna KAPELLA , Elias COULADOUROS , Argiris EFSTRATIADIS , BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS (BRFAA) , AGRICULTURAL UNIVERSITY OF ATHENS (AUA) , FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (FORTH)
IPC分类号： C07D401/14 , A61K45/06 , C07D213/90
摘要： 2,6-bis(((1H-benzo[d]imidazol-2-yl)thio)methyl)pyridine and N2, N6-dibenzylpyridine-2, 6-dicarboxamide derivatives and related compounds as phosphoinositide 3-kinase (PI3K) inhibitors for treating cancer. The present invention relates to pharmaceutically active 2,6-bis((1H-benzo[d]imidazol-2-yl)thio)methyl)pyridine, N2,N6-dibenzylpyridine-2, 6-dicarboxamide and N2,N6-bis(3-hydroxyphenyl) pyridine-2, 6-dicarboxamide, as well as to derivatives thereof, and to structurally related compounds. These compounds are phosphoinositide 3-kinase inhibitors (PI3K) and useful in treating or preventing cancerous diseases. The invention further relates methods of manufacturing such compounds as well as to pharmaceutical compositions and formulations comprising such compounds, optionally together with other pharmaceutically active compounds. The invention further relates to a method for determining the activity of PI3Kalpha or PI3Kalpha mutants, which method includes: a) providing a solid phase which is functionalized by immobilization of GST-GRP1-molecules onto the solid phase, b) performing a PI3Kalpha or PI3Kalpha mutant catalyzed enzyme reaction to convert PIP2 to PIP3, c) adding competitor PIP3 carrying a detectable label or reporter molecule, and d) determining enzyme activity based on the amount of PIP3 obtained in step b) which competes with competitor PIP3 for binding to the functionalized solid phase.
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公开(公告)号：US20180208597A1
公开(公告)日：2018-07-26
申请号：US15742330
申请日：2016-07-08
发明人： Dimitris STELLAS , Constantin TAMVAKOPOULOS , Apostolos KLINAKIS , Argiris EFSTRATIADIS , Zoe COURNIA
IPC分类号： C07D487/04 , C07B43/06 , A61P35/02
CPC分类号： C07D487/04 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/415 , A61K31/4196 , A61K31/444 , A61K31/517 , A61K31/519 , A61K31/566 , A61K31/58 , A61K31/635 , A61K31/704 , A61K31/7068 , A61K2300/00 , A61P35/02 , C07B43/06
摘要： The invention relates to new compounds of formula (I) that are useful in medicine, specifically in treating or preventing cancerous diseases in a mammal, to pharmaceutical compositions comprising such compounds, optionally together with other pharmaceutically active compounds, or to pharmaceutical formulations comprising such compounds or pharmaceutical compositions. The invention further relates to methods of making these compounds.
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公开(公告)号：US09730893B2
公开(公告)日：2017-08-15
申请号：US14425830
申请日：2013-09-05
IPC分类号： A61K9/127 , C12N15/113
CPC分类号： A61K9/1274 , A61K9/127 , C12N15/113 , C12N2310/14
摘要： The present invention relates to lipid assemblies, compositions, and liposomal delivery systems comprising single chain anionic lipids, and the use thereof in diagnosis and therapy. It involves the use of anionic lysolipids for modifying the surface charge of a cationic lipid composition consisting at least one type of cationic lipid, optionally in combination with one or more neutral lipids and/or one or more anionic lipids.
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公开(公告)号：US10287294B2
公开(公告)日：2019-05-14
申请号：US15742330
申请日：2016-07-08
发明人： Dimitris Stellas , Constantin Tamvakopoulos , Apostolos Klinakis , Argiris Efstratiadis , Zoe Cournia
IPC分类号： C07D487/04 , A61P35/02 , A61K31/635 , A61K31/415 , A61K31/4196 , A61K31/519 , A61K31/58 , A61K31/7068 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/444 , A61K31/517 , A61K31/566 , A61K31/704 , C07B43/06
摘要： The invention relates to new compounds of formula (I) that are useful in medicine, specifically in treating or preventing cancerous diseases in a mammal, to pharmaceutical compositions comprising such compounds, optionally together with other pharmaceutically active compounds, or to pharmaceutical formulations comprising such compounds or pharmaceutical compositions. The invention further relates to methods of making these compounds.
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公开(公告)号：US20180372754A1
公开(公告)日：2018-12-27
申请号：US16065663
申请日：2016-12-23
申请人： Polyquant GmbH , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS , LUXEMBOURG INSTITUTE OF HEALTH , INSTITUT CURIE , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , DIAGNOSWISS SA , FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III, CNIO
发明人： Jerome GARIN , Christophe MASSELON , Antonia VLAHOU , Manousos MAKRYDAKIS , Ieronimos ZOIDAKIS , Bruno DOMON , Elodie DURIEZ , Aurelie KAMOUN , Francois RADVANYI , Yves ALLORY , Nuria MALATS RIERA , Mirari MARQUEZ CID , Magali COURT
IPC分类号： G01N33/68 , C07K16/30 , C07K7/08 , G01N33/574 , C07K14/54
摘要： The invention relates to a collection of signature peptides representing at least 10 proteins for use in cancer diagnosis and/or prognosis, to an artificial protein comprising signature peptides representing at least 10 proteins and to a nucleic acid construct encoding for such an artificial protein. The invention further relates to a collection of at least 10 proteins for use in cancer diagnosis and/or prognosis. Additionally, the invention relates to a method for cancer diagnosis and/or prognosis comprising the step of analyzing at least 10 proteins in a urine sample of a subject. Finally, the invention relates to an immunoassay product comprising antibodies for detecting at least 10 proteins.
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