公开(公告)号：US09445870B2

公开(公告)日：2016-09-20

申请号：US13576589

申请日：2011-02-01

申请人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

发明人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

IPC分类号： A61F9/007 ,  A61N5/06 ,  A61B18/20 ,  A61F9/008

CPC分类号： A61B18/20 ,  A61F9/0079 ,  A61F2009/00872 ,  A61N5/062

摘要： Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

摘要翻译： 用于将治疗或诊断能量（例如，光，超声，电离辐射（例如，x射线），振动，热能等）递送到眼睛中的方法和装置。 能量发射装置位于眼睛上，用于将能量输送到眼睛中。 该装置可被构造成允许被检者的眼皮在设备定位在眼睛上时打开和关闭。 该装置可用于各种基于能量或能量介导的疗法，包括角膜胶原交联，光疗法，光动力疗法，药物光激活等。

公开(公告)号：US07704247B2

公开(公告)日：2010-04-27

申请号：US10778663

申请日：2004-02-13

申请人： Barbara Ann Soltz ,  Robert Soltz ,  Michael Andrew Soltz

发明人： Barbara Ann Soltz ,  Robert Soltz ,  Michael Andrew Soltz

IPC分类号： A61B18/18

CPC分类号： A61B18/22 ,  A61B2017/00057 ,  A61B2017/00084

摘要： Consistent with the present invention, a tube is provided that contains both a sensing and a laser delivery fiber to the target area. The length of the tube can be varied to any desired length. The end portion of the tube includes a second piece, which is a cap having two through holes or passages. These holes can be formed by standard machining or micromaching methods. The first hole can accommodate the sensing fiber, while the second hole contains the laser delivery fiber. The first and second holes extend in first and second directions, respectively, and form an angle therebetween such that the sensor fiber viewing area is within the radiation area created by the laser delivery fiber. Accordingly, the sensor fiber receives energy emitted from a central portion of the radiation area so that the temperature of the exposed tissue can be accurately determined.

摘要翻译： 根据本发明，提供了一种管，其包含感测和激光输送光纤到目标区域。 管的长度可以变化到任何期望的长度。 管的端部包括具有两个通孔或通道的帽的第二件。 这些孔可以通过标准机械加工或微型加工形成。 第一个孔可以容纳感测纤维，而第二个孔包含激光输送纤维。 第一和第二孔分别在第一和第二方向上延伸，并在它们之间形成角度，使得传感器光纤观察区域在由激光输送光纤产生的辐射区域内。 因此，传感器光纤接收从辐射区域的中心部分发射的能量，从而可以准确地确定曝光的组织的温度。

公开(公告)号：US20150250575A1

公开(公告)日：2015-09-10

申请号：US14547113

申请日：2014-11-18

申请人： Barbara Ann Soltz ,  Robert Soltz

发明人： Barbara Ann Soltz ,  Robert Soltz

IPC分类号： A61F2/00 ,  A61L27/50 ,  A61L27/34 ,  A61B18/20 ,  A61B17/064

CPC分类号： A61F2/0063 ,  A61B18/20 ,  A61B2018/00619 ,  A61F2210/0085 ,  A61F2220/005 ,  A61F2230/0002 ,  A61F2230/0063 ,  A61F2240/002 ,  A61F2250/006 ,  A61F2250/0062 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/442 ,  C08L89/06

摘要： Consistent with the present disclosure a method is provided in which a plurality of surgical meshes are provided, each of which may include a coating that has a chromophore. Alternatively, each mesh has a plurality of rivets or tacks that include the chromophore. The meshes may then be positioned to overlap one another or be provided adjacent one another inside the body cavity such that the mesh cover the wound site. The meshes may then be exposed to light at a wavelength that activates the chromophore and causes the meshes to adhere to one another and the underlying tissue. In one example, the coating or the tacks includes a combination of relatively high concentration derivatized collagen and riboflavin, lumiflavin or lumichrome.

摘要翻译： 根据本公开，提供了一种方法，其中提供多个外科手术网，每个手术网可以包括具有发色团的涂层。 或者，每个网格具有包括发色团的多个铆钉或钉。 然后可以将网眼定位成彼此重叠或彼此相邻地设置在体腔内，使得网覆盖伤口部位。 然后可以将网格以激活发色团的波长暴露于光，并使网格彼此粘附和下面的组织。 在一个实例中，涂层或者粘合剂包括相对高浓度衍生的胶原和核黄素，lumiflavin或lumichrome的组合。

公开(公告)号：US20130211389A1

公开(公告)日：2013-08-15

申请号：US13576589

申请日：2011-02-01

申请人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

发明人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

IPC分类号： A61B18/20

CPC分类号： A61B18/20 ,  A61F9/0079 ,  A61F2009/00872 ,  A61N5/062

摘要： Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

摘要翻译： 用于将治疗或诊断能量（例如，光，超声，电离辐射（例如，x射线），振动，热能等）递送到眼睛中的方法和装置。 能量发射装置位于眼睛上，用于将能量输送到眼睛中。 该装置可被构造成允许被检者的眼皮在设备定位在眼睛上时打开和关闭。 该装置可用于各种基于能量或能量介导的疗法，包括角膜胶原交联，光疗法，光动力疗法，药物光激活等。

公开(公告)号：US20090192437A1

公开(公告)日：2009-07-30

申请号：US12236986

申请日：2008-09-24

申请人： Robert Soltz ,  Barbara Ann Soltz ,  Ashley Behrens

发明人： Robert Soltz ,  Barbara Ann Soltz ,  Ashley Behrens

IPC分类号： A61F9/00 ,  A61M37/00

CPC分类号： A61N5/0613 ,  A61F9/0079 ,  A61F9/008 ,  A61F2009/00872 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0652

摘要： The invention provides a wearable device for delivery of light of a desired wavelength and power to the cornea of a subject. The device includes a frame for attachment of a light source housing which includes a light source and a lens positioned in the housing to allow light to be directed to the eye of the subject, and the light source is operably linked to a power source. The invention provides method for the prevention and treatment of ocular disease including infection, neoplasia, and corneal dystrophies. The device of the invention can be used in conjunction with photoactive therapeutic agents.

摘要翻译： 本发明提供了一种用于将所需波长和功率的光递送到受试者的角膜的可佩戴装置。 该装置包括用于附接光源壳体的框架，该光源壳体包括光源和位于壳体中的透镜，以允许光被引导到被摄体的眼睛，并且光源可操作地连接到电源。 本发明提供了预防和治疗包括感染，瘤形成和角膜营养不良症在内的眼部疾病的方法。 本发明的装置可以与光活性治疗剂结合使用。