公开(公告)号：US09445870B2

公开(公告)日：2016-09-20

申请号：US13576589

申请日：2011-02-01

申请人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

发明人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

IPC分类号： A61F9/007 ,  A61N5/06 ,  A61B18/20 ,  A61F9/008

CPC分类号： A61B18/20 ,  A61F9/0079 ,  A61F2009/00872 ,  A61N5/062

摘要： Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

摘要翻译： 用于将治疗或诊断能量（例如，光，超声，电离辐射（例如，x射线），振动，热能等）递送到眼睛中的方法和装置。 能量发射装置位于眼睛上，用于将能量输送到眼睛中。 该装置可被构造成允许被检者的眼皮在设备定位在眼睛上时打开和关闭。 该装置可用于各种基于能量或能量介导的疗法，包括角膜胶原交联，光疗法，光动力疗法，药物光激活等。

公开(公告)号：US07704247B2

公开(公告)日：2010-04-27

申请号：US10778663

申请日：2004-02-13

申请人： Barbara Ann Soltz ,  Robert Soltz ,  Michael Andrew Soltz

发明人： Barbara Ann Soltz ,  Robert Soltz ,  Michael Andrew Soltz

IPC分类号： A61B18/18

CPC分类号： A61B18/22 ,  A61B2017/00057 ,  A61B2017/00084

摘要： Consistent with the present invention, a tube is provided that contains both a sensing and a laser delivery fiber to the target area. The length of the tube can be varied to any desired length. The end portion of the tube includes a second piece, which is a cap having two through holes or passages. These holes can be formed by standard machining or micromaching methods. The first hole can accommodate the sensing fiber, while the second hole contains the laser delivery fiber. The first and second holes extend in first and second directions, respectively, and form an angle therebetween such that the sensor fiber viewing area is within the radiation area created by the laser delivery fiber. Accordingly, the sensor fiber receives energy emitted from a central portion of the radiation area so that the temperature of the exposed tissue can be accurately determined.

摘要翻译： 根据本发明，提供了一种管，其包含感测和激光输送光纤到目标区域。 管的长度可以变化到任何期望的长度。 管的端部包括具有两个通孔或通道的帽的第二件。 这些孔可以通过标准机械加工或微型加工形成。 第一个孔可以容纳感测纤维，而第二个孔包含激光输送纤维。 第一和第二孔分别在第一和第二方向上延伸，并在它们之间形成角度，使得传感器光纤观察区域在由激光输送光纤产生的辐射区域内。 因此，传感器光纤接收从辐射区域的中心部分发射的能量，从而可以准确地确定曝光的组织的温度。

公开(公告)号：US20150250575A1

公开(公告)日：2015-09-10

申请号：US14547113

申请日：2014-11-18

申请人： Barbara Ann Soltz ,  Robert Soltz

发明人： Barbara Ann Soltz ,  Robert Soltz

IPC分类号： A61F2/00 ,  A61L27/50 ,  A61L27/34 ,  A61B18/20 ,  A61B17/064

CPC分类号： A61F2/0063 ,  A61B18/20 ,  A61B2018/00619 ,  A61F2210/0085 ,  A61F2220/005 ,  A61F2230/0002 ,  A61F2230/0063 ,  A61F2240/002 ,  A61F2250/006 ,  A61F2250/0062 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/442 ,  C08L89/06

摘要： Consistent with the present disclosure a method is provided in which a plurality of surgical meshes are provided, each of which may include a coating that has a chromophore. Alternatively, each mesh has a plurality of rivets or tacks that include the chromophore. The meshes may then be positioned to overlap one another or be provided adjacent one another inside the body cavity such that the mesh cover the wound site. The meshes may then be exposed to light at a wavelength that activates the chromophore and causes the meshes to adhere to one another and the underlying tissue. In one example, the coating or the tacks includes a combination of relatively high concentration derivatized collagen and riboflavin, lumiflavin or lumichrome.

摘要翻译： 根据本公开，提供了一种方法，其中提供多个外科手术网，每个手术网可以包括具有发色团的涂层。 或者，每个网格具有包括发色团的多个铆钉或钉。 然后可以将网眼定位成彼此重叠或彼此相邻地设置在体腔内，使得网覆盖伤口部位。 然后可以将网格以激活发色团的波长暴露于光，并使网格彼此粘附和下面的组织。 在一个实例中，涂层或者粘合剂包括相对高浓度衍生的胶原和核黄素，lumiflavin或lumichrome的组合。

公开(公告)号：US20130211389A1

公开(公告)日：2013-08-15

申请号：US13576589

申请日：2011-02-01

申请人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

发明人： Roy S. Chuck ,  Barbara Ann Soltz ,  Robert Soltz

IPC分类号： A61B18/20

CPC分类号： A61B18/20 ,  A61F9/0079 ,  A61F2009/00872 ,  A61N5/062

摘要： Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

摘要翻译： 用于将治疗或诊断能量（例如，光，超声，电离辐射（例如，x射线），振动，热能等）递送到眼睛中的方法和装置。 能量发射装置位于眼睛上，用于将能量输送到眼睛中。 该装置可被构造成允许被检者的眼皮在设备定位在眼睛上时打开和关闭。 该装置可用于各种基于能量或能量介导的疗法，包括角膜胶原交联，光疗法，光动力疗法，药物光激活等。

公开(公告)号：US20090192437A1

公开(公告)日：2009-07-30

申请号：US12236986

申请日：2008-09-24

申请人： Robert Soltz ,  Barbara Ann Soltz ,  Ashley Behrens

发明人： Robert Soltz ,  Barbara Ann Soltz ,  Ashley Behrens

IPC分类号： A61F9/00 ,  A61M37/00

CPC分类号： A61N5/0613 ,  A61F9/0079 ,  A61F9/008 ,  A61F2009/00872 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0652

摘要： The invention provides a wearable device for delivery of light of a desired wavelength and power to the cornea of a subject. The device includes a frame for attachment of a light source housing which includes a light source and a lens positioned in the housing to allow light to be directed to the eye of the subject, and the light source is operably linked to a power source. The invention provides method for the prevention and treatment of ocular disease including infection, neoplasia, and corneal dystrophies. The device of the invention can be used in conjunction with photoactive therapeutic agents.

摘要翻译： 本发明提供了一种用于将所需波长和功率的光递送到受试者的角膜的可佩戴装置。 该装置包括用于附接光源壳体的框架，该光源壳体包括光源和位于壳体中的透镜，以允许光被引导到被摄体的眼睛，并且光源可操作地连接到电源。 本发明提供了预防和治疗包括感染，瘤形成和角膜营养不良症在内的眼部疾病的方法。 本发明的装置可以与光活性治疗剂结合使用。

公开(公告)号：US20160250377A1

公开(公告)日：2016-09-01

申请号：US14656994

申请日：2015-03-13

申请人： Barbara A. Soltz ,  Robert Soltz

发明人： Barbara A. Soltz ,  Robert Soltz

IPC分类号： A61L24/10 ,  A61L24/00 ,  A61B17/00

CPC分类号： A61L24/102 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/005 ,  A61B2017/00517 ,  A61B2017/00884 ,  A61B2017/00951 ,  A61K9/7007 ,  A61K31/525 ,  A61K38/39 ,  A61K47/42 ,  A61L24/0015 ,  A61L31/044 ,  A61L31/14 ,  A61L2300/428 ,  A61K2300/00

摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.

摘要翻译： 应用包含核黄素的光活化胶原蛋白 - 黄素复合物层作为感染病变的治疗。 这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强力组织粘合剂。 优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。 将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。 胶原蛋白复合物和组织之间的强烈交联结果。 此外，类似的暴露可以消除伤口中的病原体。

公开(公告)号：US20090234376A1

公开(公告)日：2009-09-17

申请号：US12378568

申请日：2009-02-17

申请人： Michael Andrew Soltz ,  Robert Soltz ,  Raymond J. Lanzafame

发明人： Michael Andrew Soltz ,  Robert Soltz ,  Raymond J. Lanzafame

IPC分类号： A61B17/03

CPC分类号： A61F2/0063 ,  A61B17/3468 ,  A61F2002/0072

摘要： Consistent with an aspect of the present disclosure, a mesh or other surgical material is wrapped about one or more shafts, and inserted into a body cavity where it is unfurled and placed over a tissue site, such as a hernia. The mesh, for example, is secured to the shaft in order to prevent crimping or crumpling thereof during deployment over the tissue site.

摘要翻译： 根据本公开的一个方面，网状物或其他外科手术材料围绕一个或多个轴缠绕，并且插入体腔中，在其中它被展开并放置在诸如疝的组织部位上。 例如，网状物固定到轴上，以防止在组织部位展开期间卷曲或弄皱。

公开(公告)号：US06780840B1

公开(公告)日：2004-08-24

申请号：US09973263

申请日：2001-10-09

申请人： Dale P. DeVore ,  Braden P. DeVore ,  Barbara A. Soltz ,  Robert Soltz ,  Michael A. Soltz

发明人： Dale P. DeVore ,  Braden P. DeVore ,  Barbara A. Soltz ,  Robert Soltz ,  Michael A. Soltz

IPC分类号： A61K3800

CPC分类号： A61B18/22 ,  A61B17/00491 ,  A61B2017/0007 ,  A61B2017/00084 ,  A61B2017/005 ,  A61B2017/00508 ,  A61B2017/00517 ,  A61L24/102

摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.

摘要翻译： 根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。 组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。 特别地，例如，首先通过从牛或猪皮提取而制备I型胶原并纯化。 然后将胶原蛋白制剂用巯基试剂进行化学衍生，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。 然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。 固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。 随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。

公开(公告)号：US09006182B2

公开(公告)日：2015-04-14

申请号：US12943763

申请日：2010-11-10

申请人： Barbara A. Soltz ,  Robert Soltz

发明人： Barbara A. Soltz ,  Robert Soltz

IPC分类号： A61K38/39 ,  A61K47/48 ,  A61K38/00 ,  A61P43/00 ,  A61B17/50 ,  A61B17/08 ,  A61D1/00 ,  A61K38/17 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C09H1/00 ,  C07K17/00 ,  C08H1/00 ,  A61F13/00 ,  A61F2/00 ,  A61K9/70 ,  A61B17/00 ,  A61K31/525 ,  A61K47/42 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61L24/102 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/005 ,  A61B2017/00517 ,  A61B2017/00884 ,  A61B2017/00951 ,  A61K9/7007 ,  A61K31/525 ,  A61K38/39 ,  A61K47/42 ,  A61L24/0015 ,  A61L31/044 ,  A61L31/14 ,  A61L2300/428 ,  A61K2300/00

摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.

摘要翻译： 应用包含核黄素的光活化胶原蛋白 - 黄素复合物层作为感染病变的治疗。 这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强组织粘附。 优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。 将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。 胶原蛋白复合物和组织之间的强烈交联结果。 此外，类似的暴露可以消除伤口中的病原体。

公开(公告)号：US06773699B1

公开(公告)日：2004-08-10

申请号：US09973385

申请日：2001-10-09

申请人： Barbara A. Soltz ,  Dale P. DeVore ,  Braden P. DeVore ,  Robert Soltz ,  Michael A. Soltz

发明人： Barbara A. Soltz ,  Dale P. DeVore ,  Braden P. DeVore ,  Robert Soltz ,  Michael A. Soltz

IPC分类号： A61K3800

CPC分类号： A61B18/22 ,  A61B17/00491 ,  A61B2017/0007 ,  A61B2017/00084 ,  A61B2017/005 ,  A61B2017/00508 ,  A61B2017/00517 ,  A61L31/044

摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 80 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films which are used to encapsulate structural components such as a cojoinal network or mesh. The resultant patch which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space and are reinforced by the embedded cojoinal network or mesh.

摘要翻译： 根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。 组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至80mg / ml（80％））的胶原蛋白。 特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。 然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。 然后将组合物形成粘稠溶液，凝胶或固体膜，其用于包封结构组分如共同网络或网状物。 例如，当暴露于由红外激光器产生的能量时，产生的贴片经历热诱导相变。 固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。 随着热能释放到周围环境中，蛋白质组合物再次变成固体或半固体，粘附到经处理的组织或组织空间，并通过嵌入的共同网络或网来加强。