公开(公告)号：US20060051806A1

公开(公告)日：2006-03-09

申请号：US11252452

申请日：2005-10-18

申请人： Barry Rothenberg ,  Ritsuko Sawada-Hiraj ,  James Barton

发明人： Barry Rothenberg ,  Ritsuko Sawada-Hiraj ,  James Barton

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The invention features a method of diagnosing an iron disorder, e.g., hemochromatosis, or a genetic susceptibility to developing such a disorder in a mammal by determining the presence of a mutation in exon 2 or in an intron of an HFE nucleic acid.

公开(公告)号：US20050129751A1

公开(公告)日：2005-06-16

申请号：US10738604

申请日：2003-12-16

申请人： Barry Rothenberg ,  Fusun Zeytin ,  Robert Fish

发明人： Barry Rothenberg ,  Fusun Zeytin ,  Robert Fish

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K9/16 ,  A61K9/22 ,  A61K9/50 ,  A61K9/52 ,  A61K39/00 ,  A61K47/48

CPC分类号： A61K9/127 ,  A61K9/0024 ,  A61K9/1075 ,  A61K47/585

摘要： Contemplated drug delivery systems allow controlled release of a drug in a manner that is independent of the physicochemical parameters of both the drug and its carrier. In one preferred aspect, the drug and the carrier are released from a second carrier that has a predefined release characteristics, which is predominantly determined by the physicochemical properties of the second carrier.

摘要翻译： 考虑的药物递送系统允许以与药物及其载体的物理化学参数无关的方式控制释放药物。 在一个优选的方面，药物和载体从具有预定释放特性的第二载体释放，其主要由第二载体的物理化学性质决定。

公开(公告)号：US20050155099A1

公开(公告)日：2005-07-14

申请号：US11014148

申请日：2004-12-15

申请人： Barry Rothenberg ,  Fusun Zeytin ,  Robert Fish

发明人： Barry Rothenberg ,  Fusun Zeytin ,  Robert Fish

IPC分类号： C12N5/071 ,  C12N5/0735 ,  C12N15/86

CPC分类号： C12N5/067 ,  C12N5/0606 ,  C12N2500/02

摘要： A primary mammalian cell which may be infected with a pathogen is cultivated under reduced oxygen to improve susceptibility to infection with a pathogen, pathogen propagation, and/or to change or maintain a degree of differentiation of the cell in a predetermined manner. In preferred aspects, the cell is a hepatocyte, optionally infected with HCV, or a blastomere from a single-cell biopsied blastocyst. Such biopsied cell may then be expanded to a population of stem cells under concurrent cultivation of the blastocyst, which is then used for IVF implantation.

摘要翻译： 在减少的氧气下培养可能被病原体感染的主要哺乳动物细胞，以改善对感染病原体，病原体繁殖的易感性，和/或以预定方式改变或维持细胞的分化程度。 在优选方面，细胞是肝细胞，任选地被HCV感染，或来自单细胞活组织囊胚的卵裂球。 然后可以在并行培养囊胚的情况下将这样的活检细胞扩大到干细胞群，然后将其用于IVF植入。