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    Delivery of superoxide dismutase to neuronal cells
    1.
    发明申请
    Delivery of superoxide dismutase to neuronal cells 失效
    将超氧化物歧化酶递送至神经元细胞

    公开(公告)号：US20050255093A1

    公开(公告)日：2005-11-17

    申请号：US11062471

    申请日：2005-02-22

    申请人： Clifford Shone ,  John Sutton ,  Bassam Hallis ,  Nigel Silman

    发明人： Clifford Shone ,  John Sutton ,  Bassam Hallis ,  Nigel Silman

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/44 ,  A61K47/48 ,  A61K48/00 ,  A61P25/28 ,  A61P39/06 ,  C07K14/33 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N15/53 ,  A61K39/08

    CPC分类号： C12N9/0089 ,  A61K38/00 ,  A61K47/6415 ,  A61K48/00 ,  C07K14/33 ,  C07K2319/00

    摘要： A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dimutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dimutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondira.

    摘要翻译： 用于将超氧化物歧化酶递送至神经元细胞的组合物包含通过接头与神经元细胞靶向组分连接的超氧化物歧化酶，该组分包含结合神经元细胞的第一结构域和将超氧化物二聚体转位到神经细胞中的第二结构域 。 易位后，切割接头以从神经元细胞靶向结构域释放超氧化物歧化酶。 还描述了用于治疗对神经元细胞的氧化损伤的组合物的使用，并且使用人线粒体前导序列进一步靶向组合物。 描述了含有细菌超氧化物歧化酶加上靶向人线粒体的序列的杂合多肽。

    Anthrax antigenic compositions
    2.
    发明申请
    Anthrax antigenic compositions 审中-公开
    炭疽抗原组合物

    公开(公告)号：US20050112145A1

    公开(公告)日：2005-05-26

    申请号：US10494384

    申请日：2002-11-01

    申请人： Michael Hudson ,  Andrew Robinson ,  Nigel Silman ,  Bassam Hallis ,  Charles Penn

    发明人： Michael Hudson ,  Andrew Robinson ,  Nigel Silman ,  Bassam Hallis ,  Charles Penn

    IPC分类号： C12N15/09 ,  A61K39/02 ,  A61K39/07 ,  A61K48/00 ,  A61P31/04 ,  C12N15/31 ,  C12P21/02

    CPC分类号： A61K39/07

    摘要： An antigenic pharmaceutical composition is provided comprising Protective Antigen (PA) and Lethal Factor (LF), wherein said PA and/or LF lacks a functional binding site, thereby preventing said PA and LF from binding together via said binding site or thereby preventing said PA from binding to a native PA cell receptor via said binding site, and wherein said composition is substantially non-toxic to animal cells. The composition is for preventing or minimising anthrax toxicity in mammals, preferably in humans. Also provided are DNA and RNA based vaccines encoding the antigenic components of said pharmaceutical composition. The present specification also describes antibodies that bind to at least one of PA, LF or EF, which binding thereby prevents:—(i) PA from binding to LF or EF, or to a native PA cell receptor; or (ii) LF from binding to PA; or (iii) EF from binding to PA.

    摘要翻译： 提供了包含保护性抗原（PA）和致死因子（LF）的抗原性药物组合物，其中所述PA和/或LF缺少功能性结合位点，从而防止所述PA和LF通过所述结合位点结合在一起，从而防止所述PA 通过所述结合位点与天然PA细胞受体结合，并且其中所述组合物对动物细胞基本上无毒性。 该组合物用于预防或最小化哺乳动物中的炭疽毒性，优选在人体内。 还提供了编码所述药物组合物的抗原成分的基于DNA和RNA的疫苗。 本说明书还描述了结合至少一种PA，LF或EF的抗体，其结合从而防止： - （i）PA结合LF或EF或天然PA细胞受体; 或（ii）LF结合PA; 或（iii）EF结合PA。

    Delivery of superoxide dismutase to neuronal cells
    5.
    发明授权
    Delivery of superoxide dismutase to neuronal cells 失效
    将超氧化物歧化酶递送至神经元细胞

    公开(公告)号：US07470661B2

    公开(公告)日：2008-12-30

    申请号：US11062471

    申请日：2005-02-22

    申请人： Clifford Charles Shone ,  John Mark Sutton ,  Bassam Hallis ,  Nigel Silman

    发明人： Clifford Charles Shone ,  John Mark Sutton ,  Bassam Hallis ,  Nigel Silman

    IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/43 ,  C07K14/00 ,  C12N9/00

    CPC分类号： C12N9/0089 ,  A61K38/00 ,  A61K47/6415 ,  A61K48/00 ,  C07K14/33 ,  C07K2319/00

    摘要： A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dimutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dimutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondira.

    摘要翻译： 用于将超氧化物歧化酶递送至神经元细胞的组合物包含通过接头与神经元细胞靶向组分连接的超氧化物歧化酶，该组分包含结合神经元细胞的第一结构域和将超氧化物二聚体转位到神经元细胞中的第二结构域 。 易位后，切割接头以从神经元细胞靶向结构域释放超氧化物歧化酶。 还描述了用于治疗对神经元细胞的氧化损伤的组合物的使用，并且使用人线粒体前导序列进一步靶向组合物。 描述了含有细菌超氧化物歧化酶加上靶向人线粒体的序列的杂合多肽。