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公开(公告)号：US20080167221A9
公开(公告)日：2008-07-10
申请号：US10522457
申请日：2003-08-25
IPC分类号： A61K38/16 , C07K14/415
CPC分类号： A61K36/75
摘要： The invention relates to a plant-derived protein with anti-cancer properties which binds the human growth hormone-releasing hormone (hGHRH). Said protein, which is obtained from the Pilocarpus Heterophyllus plant, is particularly adapted for preparing a medicament that is intended for the treatment of cancers for which growth is dependant on the GHRH growth factor and, in particular, for preparing a medicament that is intended for the treatment of cancers including small cell lung cancer and breast cancer.
摘要翻译： 本发明涉及结合人生长激素释放激素（hGHRH）的具有抗癌特性的植物来源的蛋白质。 所述蛋白质，其从所述皮毛菌属植物获得，特别适用于制备用于治疗生长依赖于GHRH生长因子的癌症的药物，特别是用于制备用于 治疗癌症包括小细胞肺癌和乳腺癌。
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公开(公告)号：US07494969B2
公开(公告)日：2009-02-24
申请号：US10522457
申请日：2003-08-25
CPC分类号： A61K36/75
摘要： A method of treating cancer dependent on growth factor GHRH in warm-blooded animals in need thereof with an isolated protein extended for Pilocarpus Heterophyllus.
摘要翻译： 一种在有需要的温血动物中治疗依赖于生长因子GHRH的癌症的方法，其具有扩展为Pilocarpus Heterophyllus的分离的蛋白质。
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3.发明授权Method for preparing an extract of ginkgo biloba leaves highly enriched in active principles 失效银杏叶提取物的制备方法高度富集活性成分公开(公告)号：US07048954B2
公开(公告)日：2006-05-23
申请号：US10472408
申请日：2002-04-09
申请人： Beng Poon Teng
发明人： Beng Poon Teng
IPC分类号： A61K35/78
CPC分类号： A61K36/16
摘要： A process for the preparation of an extract of Ginkgo biloba leaves, comprising i. extraction of the dried fragments of Ginkgo biloba leaves in ethanol containing a maximum of 20% by weight of water; ii. concentration of the extract under reduced pressure in the presence of an aqueous solution of sodium chloride and elimination of the dark oil from the remainder of the clear solution; iii. washing of the residual aqueous solution by liquid-liquid extraction with n-hexane, n-heptane or cyclohexane, iv. liquid-liquid extraction of the aqueous phase washed with ethyl acetate; and v. washing of the ethyl acetate phase obtained in stage iv with a sodium chloride solution followed by evaporation to dryness of the washed ethyl acetate phase and use of the resulting extract to treat cerebral and peripheral vascular disorders and neurodegenerative diseases.
摘要翻译： 一种制备银杏提取物的方法，包括i。 在含有最多20重量％水的乙醇中提取银杏叶的干燥片段; ii。 在氯化钠水溶液存在下减压浓缩萃取物，并从澄清溶液的其余部分除去深色油状物; iii。 用正己烷，正庚烷或环己烷进行液 - 液萃取洗涤残余水溶液，iv。 用乙酸乙酯洗涤水相的液 - 液萃取; 和v。用氯化钠溶液洗涤在阶段iv中获得的乙酸乙酯相，然后蒸发至干洗的乙酸乙酯相，并使用得到的提取物来治疗脑和周围血管疾病和神经变性疾病。
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公开(公告)号：US06887869B2
公开(公告)日：2005-05-03
申请号：US10250383
申请日：2002-01-11
IPC分类号： A61K31/34 , A61K31/343 , A61P9/10 , A61P13/08 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07D493/18 , C07D493/08 , C07D493/22
CPC分类号： C07D493/18
摘要： The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1 and (I)2, wherein: R1 represents H, SR4 or NR4R5; R2 represents SR6 or NR6R7; R3 represents OH, O(CO)R14, OSiR15R16R17, O(CO)OR18 or O(CO)NHR18, each of the radicals R4, R6, R15, R16 and R17 representing independently (in particular) an alkyl radical, the radicals R5 and R7 representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R14 and R18 representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)2, then R1 does not represent a hydrogen atom
摘要翻译： 本发明涉及新颖的米卡尼定衍生物，其制备方法及其治疗用途，特别是抗癌和抗病毒剂。 化合物对应于对应于通式（I）的通式（1）1和2其中：R 1 表示H，SR 4或NR 4 R 5; R 2表示SR 6或NR 6 R 7; R 3表示OH，O（CO）R 14，OSiR 15 R 16 R 17， O（CO）OR 18或O（CO）NHR 18，基团R 4，R 3， R 6，R 15，R 16和R 17独立地表示（特别是）烷基，基团R 时，R 1不表示氢原子
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公开(公告)号：US07385024B2
公开(公告)日：2008-06-10
申请号：US10470112
申请日：2002-02-26
IPC分类号： A61K38/00
CPC分类号： C07K14/415 , A61K38/00
摘要： The invention relates to a human GHRH-binding protein (human Growth Hormone-releasing hormone). Said protein, which is obtained from the Pilocarpus Heterophyllus plant, can be used to prepare medicaments intended to antagonise the effects of GHRH and to treat proliferative diseases (particularly cancer), acromegaly or diabetic nephropathies and retinopathies.
摘要翻译： 本发明涉及人GHRH结合蛋白（人生长激素释放激素）。 所述蛋白质可从Pilocarpus Heterophyllus植物获得，可用于制备旨在拮抗GHRH的作用并治疗增殖性疾病（特别是癌症），肢端肥大症或糖尿病性肾病和视网膜病变的药物。
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公开(公告)号：US20060178300A1
公开(公告)日：2006-08-10
申请号：US10522457
申请日：2003-08-25
IPC分类号： A61K38/16 , C07K14/415
CPC分类号： A61K36/75
摘要： The invention relates to a plant-derived protein with anti-cancer properties which binds the human growth hormone-releasing hormone (hGHRH). Said protein, which is obtained from the Pilocarpus Heterophyllus plant, is particularly adapted for preparing a medicament that is intended for the treatment of cancers for which growth is dependant on the GHRH growth factor and, in particular, for preparing a medicament that is intended for the treatment of cancers including small cell lung cancer and breast cancer.
摘要翻译： 本发明涉及结合人生长激素释放激素（hGHRH）的具有抗癌特性的植物来源的蛋白质。 所述蛋白质，其从所述皮毛菌属植物获得，特别适用于制备用于治疗生长依赖于GHRH生长因子的癌症的药物，特别是用于制备用于 治疗癌症包括小细胞肺癌和乳腺癌。
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公开(公告)号：US5599950A
公开(公告)日：1997-02-04
申请号：US287632
申请日：1994-08-04
申请人： Beng-Poon Teng
发明人： Beng-Poon Teng
IPC分类号： C07D493/22 , C07H19/01 , C07D307/93
CPC分类号： C07D493/22 , C07H19/01
摘要： A two-step process for converting ginkgolide C into ginkgolide B is disclosed. In the first step, ginkgolide C is reacted with a sulfonic anhydride to obtain a C-7 sulfonate of ginkgolide C. In the second step, the C-7 sulfonate of ginkgolide C is reacted with a borohydride, and this reaction eliminates the C-7 radical of the C-7 sulfonate of ginkgolide C, thus producing ginkgolide B.
摘要翻译： 公开了将银杏内酯C转化为银杏内酯B的两步法。 在第一步中，银杏内酯C与磺酸酐反应得到银杏内酯C的C-7磺酸盐。在第二步中，将银杏内酯C的C-7磺酸盐与硼氢化钠反应， 7基团的银杏内酯C的C-7磺酸盐C，从而生产银杏内酯B.
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公开(公告)号：US5241084A
公开(公告)日：1993-08-31
申请号：US860165
申请日：1992-03-30
申请人： Beng-Poon Teng
发明人： Beng-Poon Teng
IPC分类号： A61K31/34 , A61K31/343 , A61K36/00 , A61P35/00 , A61P43/00 , C07D493/22
CPC分类号： C07D493/22 , Y02P20/55
摘要： The invention relates to a process for the preparation of ginkgolide B from ginkgolide C and to ginkgolide B thus obtained, the process comprising the following succession of four steps:protecting the 10-hydroxy group of ginkgolide C by conversion to an alkyl ester, the reaction being effected in dimethylformamide at a temperature of from 15.degree. to 50.degree. C. for from 4 to 10 hours;activating the 7-hydroxy group of the resultant 10-protected ginkgolide C by conversion to a (R)thiocarbonyl ester, the activation being effected in basic conditions at a temperature of from 0.degree. to 40.degree. C. for from 1 to 24 hours;deoxygenating the 7-activated group in the resultant 10-protected 7-activated ginkgolide C by treating it with tributyltin hydride or tris-(trimethylsilyl)silane, in an aprotic solvent, in the presence of a free-radical generator, the reaction being effected at a temperature of from 70.degree. to 110.degree. C. for from 15 minutes to 3 hours under inert atmosphere, andcleaving the protecting group from the 10-hydroxy group of the resultant 10-protected ginkgolide B.
摘要翻译： 本发明涉及从银杏内酯C和由此获得的银杏内酯B制备银杏内酯B的方法，该方法包括以下连续四个步骤：通过转化成烷基酯保护银杏内酯C的10-羟基，反应 在二甲基甲酰胺中，在15℃至50℃的温度下进行4至10小时; 通过转化为（R）硫代羰基酯来活化所得10-保护的银杏内酯C的7-羟基，该活化在碱性条件下在0℃至40℃的温度下进行1至24小时; 通过在非质子传递溶剂中，在自由基发生剂的存在下，用三丁基锡氢化物或三（三甲基甲硅烷基）硅烷处理，使得到的10保护的7-活化银杏内酯C中的7-活化基团脱氧， 在惰性气氛下，在70〜110℃的温度下反应15分钟〜3小时，并将保护基与所得10个保护的银杏内酯B的10-羟基切断。
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