公开(公告)号：US20090092550A1

公开(公告)日：2009-04-09

申请号：US11572102

申请日：2005-07-15

申请人： Max Crossley ,  Pall Thordarson ,  Neil Hunter ,  Benjamin Yap ,  Charles Andrew Collyer

发明人： Max Crossley ,  Pall Thordarson ,  Neil Hunter ,  Benjamin Yap ,  Charles Andrew Collyer

IPC分类号： A61K49/00 ,  C07D245/00 ,  A61K31/40

CPC分类号： C07D487/22 ,  A61K31/4178 ,  A61K47/546 ,  Y02A50/473 ,  Y02A50/481

摘要： The present invention relates generally to targeted molecular agents (TMAs) directed to a particular organism or group of organisms and uses thereof. More particularly, the present invention provides TMAs having a targeting moiety which comprises a natural or induced auxotrophic requirement of the particular organism as a vehicle for directing an agent linked to the moiety to be delivered to the target organism. The TMAs of the present invention are useful for targeting molecules such as antimicrobial agents and diagnostic agents to selected organisms.

摘要翻译： 本发明一般涉及针对特定生物体或一组生物体的靶向分子试剂（TMA）及其用途。 更具体地，本发明提供了具有靶向部分的TMA，其包含特定生物体的天然或诱导的营养缺陷型需求，作为用于引导与要递送至靶生物体的部分连接的药剂的载体。 本发明的TMA可用于将分子例如抗微生物剂和诊断剂靶向选定的生物体。

公开(公告)号：US5823387A

公开(公告)日：1998-10-20

申请号：US63202

申请日：1993-05-18

申请人： Benjamin Yap Manadanas ,  James Michael Skaggs ,  Sean Patrick O'Sullivan ,  Christopher John Hedin

发明人： Benjamin Yap Manadanas ,  James Michael Skaggs ,  Sean Patrick O'Sullivan ,  Christopher John Hedin

IPC分类号： B65D35/24 ,  B65D35/00

CPC分类号： B65D35/242

摘要： A method an apparatus for simultaneously dispensing a plurality of viscous materials, such as dentifrice pastes, produces a striped outer layer of a first material surrounding a core of a second viscous material. The apparatus includes a collapsible tube or pump-type dispenser containing a first viscous material and a second viscous material of a contrasting color in contact with the first material so that both materials are dispensed simultaneously. The tube or dispenser includes an outlet nozzle having a shaped outlet capable of scraping and removing a portion of the outer layer of viscous material to dispense the core material having stripes of the outer material. The nozzle is capable of forming a plurality of fine pin stripes on the core material.

摘要翻译： 一种用于同时分配多种粘性材料（例如洁牙膏）的装置的方法产生围绕第二粘性材料的芯的第一材料的条纹外层。 该装置包括可折叠管或泵型分配器，其包含第一粘性材料和与第一材料接触的对比颜色的第二粘性材料，从而同时分配两种材料。 管或分配器包括具有成形出口的出口喷嘴，该成形出口能够刮除和去除粘性材料的外层的一部分以分配具有外部材料条纹的芯材料。 喷嘴能够在芯材上形成多个细针状条纹。

公开(公告)号：USD420463S

公开(公告)日：2000-02-08

申请号：US80754

申请日：1997-12-15

申请人： Prakasarao Mandadi ,  Gary Edward Tambs ,  Benjamin Yap Mandanas ,  Andrea Quadrini

设计人： Prakasarao Mandadi ,  Gary Edward Tambs ,  Benjamin Yap Mandanas ,  Andrea Quadrini