公开(公告)号：US20090092550A1

公开(公告)日：2009-04-09

申请号：US11572102

申请日：2005-07-15

申请人： Max Crossley ,  Pall Thordarson ,  Neil Hunter ,  Benjamin Yap ,  Charles Andrew Collyer

发明人： Max Crossley ,  Pall Thordarson ,  Neil Hunter ,  Benjamin Yap ,  Charles Andrew Collyer

IPC分类号： A61K49/00 ,  C07D245/00 ,  A61K31/40

CPC分类号： C07D487/22 ,  A61K31/4178 ,  A61K47/546 ,  Y02A50/473 ,  Y02A50/481

摘要： The present invention relates generally to targeted molecular agents (TMAs) directed to a particular organism or group of organisms and uses thereof. More particularly, the present invention provides TMAs having a targeting moiety which comprises a natural or induced auxotrophic requirement of the particular organism as a vehicle for directing an agent linked to the moiety to be delivered to the target organism. The TMAs of the present invention are useful for targeting molecules such as antimicrobial agents and diagnostic agents to selected organisms.

摘要翻译： 本发明一般涉及针对特定生物体或一组生物体的靶向分子试剂（TMA）及其用途。 更具体地，本发明提供了具有靶向部分的TMA，其包含特定生物体的天然或诱导的营养缺陷型需求，作为用于引导与要递送至靶生物体的部分连接的药剂的载体。 本发明的TMA可用于将分子例如抗微生物剂和诊断剂靶向选定的生物体。