公开(公告)号：US20060286660A1

公开(公告)日：2006-12-21

申请号：US10572184

申请日：2004-09-20

Applicant: Bernadette Yon-Hin

Inventor： Bernadette Yon-Hin

IPC: C12M1/34

CPC classification number: C12Q1/006

Abstract: A sensor which has at least first and second electrodes and a volume therebetween for receiving a liquid sample, includes an agent that lyses cells, wherein the lysing agent is in or on the surface of the first electrode.

Abstract translation: 具有至少第一和第二电极及其间用于接收液体样品的体积的传感器包括裂解细胞的试剂，其中所述裂解剂在所述第一电极的表面中或表面上。

公开(公告)号：US20050287035A1

公开(公告)日：2005-12-29

申请号：US11022626

申请日：2004-12-27

Applicant: Bernadette Yon-Hin ,  Stephen Williams ,  Neil Blair ,  James McCann ,  Lorna Cox

Inventor： Bernadette Yon-Hin ,  Stephen Williams ,  Neil Blair ,  James McCann ,  Lorna Cox

IPC: C12Q1/00 ,  G01N27/403 ,  G01N31/22 ,  G01N33/487

CPC classification number: C12Q1/006 ,  G01N27/3272

Abstract: A test strip for testing small volumes in which a layer of mesh or membrane material is provided, in which a small volume of liquid to be tested can be distributed and provide contact between an active electrode and counterelectrode on a support, and wherein an analyte-specific reagent is coated on the mesh or material or one of the electrodes, and in which the sample application area is at one edge of the mesh or membrane.

Abstract translation: 一种用于测试小容积的测试条，其中提供了一层网状物或膜材料，其中可以分布少量待测试的液体并且在活性电极和反电极之间提供接触，并且其中分析物 - 特定试剂涂覆在网状物或材料或电极中的一个上，其中样品施加区域位于网状物或膜的一个边缘。

公开(公告)号：US06309535B1

公开(公告)日：2001-10-30

申请号：US09297717

申请日：1999-07-19

Applicant: Stephen Charles Williams ,  Bernadette Yon-Hin ,  Neil Blair

Inventor： Stephen Charles Williams ,  Bernadette Yon-Hin ,  Neil Blair

IPC: G01N2726

CPC classification number: G01N27/308

Abstract: An electrode comprises a non-conductive substrate and a conductive layer comprising, in a bonded matrix, graphite particles coated with a noble metal, and carbon particles, wherein the graphite particles are up to 20 &mgr;m is size and have a surface area of 1-50 m2/g. This electrode is capable of measuring low levels of analyte, e.g. glucose in sweat when convined with a layer containing glucose oxidase.

Abstract translation: 一种电极包括非导电基底和导电层，导电层包括以键合基质，涂覆有贵金属的石墨颗粒和碳颗粒，其中石墨颗粒最多达20μm，其表面积为1- 50平方米/克。 该电极能够测量低水平的分析物，例如， 葡萄糖在与含有葡萄糖氧化酶的层组合时出汗。

公开(公告)号：US06020110A

公开(公告)日：2000-02-01

申请号：US765565

申请日：1997-01-27

Applicant: Stephen Charles Williams ,  Peter Thomas Arnold ,  Bernadette Yon-Hin

Inventor： Stephen Charles Williams ,  Peter Thomas Arnold ,  Bernadette Yon-Hin

IPC: G01N27/30 ,  C23F1/00 ,  G01N27/327 ,  G01N27/403 ,  G03F7/00 ,  G03F7/26

CPC classification number: G01N27/403

Abstract: A method for the production of electrodes, especially microelectrodes, in which the (micro) electrode consists essentially of an electrically-insulating material through which apertures are formed to reveal the electrically-conducting material, is characterized in that aperture as formed by the use of a light-hardened (photopolymerizing) resist or light-softened (photoinduced breaking of bonds) resist.

Abstract translation: PCT No.PCT / GB95 / 01476 Sec。 371日期1997年1月27日 102（e）日期1997年1月27日PCT提交1995年6月23日PCT公布。 WO96 / 14769 PCT公开号 日期1996年5月23日一种用于生产电极，特别是微电极的方法，其中（微）电极基本上由电绝缘材料组成，通过该电绝缘材料形成孔以露出导电材料，其特征在于形成的孔 通过使用光硬化（光聚合）抗蚀剂或光软化（光诱导断裂的键）抗蚀剂。

公开(公告)号：US06440645B1

公开(公告)日：2002-08-27

申请号：US09445650

申请日：1999-12-09

Applicant: Bernadette Yon-Hin ,  James McCann ,  Saji Eapen ,  Christopher Robin Lowe

Inventor： Bernadette Yon-Hin ,  James McCann ,  Saji Eapen ,  Christopher Robin Lowe

IPC: G03F700

CPC classification number: B81C1/00119 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L7/525 ,  B41M1/12 ,  B41M3/00 ,  B81B2203/0338 ,  B81C2201/0184

Abstract: A process for the production of a device having a surface microstructure of wells or channels. In the process one or more steps of screen-printing the microstructure as a curable material onto a plastic substrate, and curing the material. Such a device is also obtained by applying onto a substrate a material that is polymerizable or depolymerizable by irradiation, applying a negative or positive resist photoresist respectively, irradiating the structure and removing the unpolymerized or depolymerized material.

Abstract translation: 用于生产具有孔或通道的表面微结构的装置的方法。 在该过程中，将微结构作为可固化材料丝网印刷到塑料基材上的一个或多个步骤，并固化该材料。 这样的器件也可以通过将通过照射可聚合或解聚的材料分别施加到衬底上，分别施加负极或正性抗蚀剂光刻胶，照射该结构并除去未聚合或解聚的材料而获得。

公开(公告)号：US06436256B1

公开(公告)日：2002-08-20

申请号：US09445154

申请日：2000-03-06

Applicant: Stephen Charles Williams ,  Bernadette Yon-Hin ,  Neil Blair

Inventor： Stephen Charles Williams ,  Bernadette Yon-Hin ,  Neil Blair

IPC: G01N27327

CPC classification number: G01N27/3272

Abstract: A device, for use in the electrochemical analysis of an analyte in a small volume liquid sample, having a non-conducting substrate (1); a conductive layer, deposited on the substrate, in two parts (2a, 2b), defining a non-conducting gap (8) therebetween; an analyte-specific reagent (5) coated on the conductive layer, on one side of the gap; a reference electrode (3) on the conductive layer, on the other side of the gap; a spacer layer (4) deposited over the conductive layer; a monofilament mesh (6) coated with a surfactant or chaotropic agent, the mesh being laid over the reagent, the reference electrode and the spacer layer; and a second non-conductive layer (7) adhered to the mesh layer, but not coextensive therewith, thereby providing a sample application area (9) on the mesh.

Abstract translation: 一种用于电化学分析小体积液体样品中的分析物的装置，具有非导电基底（1）; 在两个部分（2a，2b）中沉积在衬底上的导电层，其间形成非导电间隙（8）; 在所述间隙的一侧上涂覆在所述导电层上的分析物特异性试剂（5）; 在所述导电层上的所述间隙的另一侧上的参考电极（3） 沉积在所述导电层上的间隔层（4）; 涂覆有表面活性剂或离液剂的单丝网（6），网格放置在试剂，参比电极和间隔层上; 以及第二非导电层（7），其粘附到网状层上，但不与其共同延伸，从而在网上提供样品施加区域（9）。