公开(公告)号：US08623002B2

公开(公告)日：2014-01-07

申请号：US10566199

申请日：2004-07-20

申请人： Michiel Errit Roersma ,  Bernardus Leonardus Gerardus Bakker

发明人： Michiel Errit Roersma ,  Bernardus Leonardus Gerardus Bakker

IPC分类号： A61B18/18

CPC分类号： A61N5/0616 ,  A61B18/20 ,  A61B18/203 ,  A61B2018/00452 ,  A61B2018/00636 ,  A61B2090/064

摘要： The present invention relates to a device for administering electromagnetic radiation to human tissue, in particular light to skin. The device comprises a treatment head with a recess (10) in which the light is emitted and in which the air pressure may be decreased by a pump (11). The device also comprises a pressure gauge (8) for measuring the pressure in the recess (10). Above a certain threshold value the device will not function, because this indicates an incorrect positioning of the device on the skin, which might cause harm to persons. By providing the pressure gauge (8), an operator may determine whether the positioning of the treatment head is correct. The device is advantageously automated in that the pressure gauge (8) is connected to control means (5) for controlling the source (3) of radiation.

摘要翻译： 本发明涉及一种用于向人体组织，特别是对皮肤照射电磁辐射的装置。 该装置包括具有凹部（10）的处理头，其中发射光，并且其中空气压力可以通过泵（11）减小。 该装置还包括用于测量凹部（10）中的压力的​​压力计（8）。 超过某个阈值时，设备将不起作用，因为这表示设备在皮肤上的定位不正确，可能会对人造成伤害。 通过提供压力计（8），操作者可以确定治疗头的定位是否正确。 该装置有利地是自动化的，因为压力计（8）连接到用于控制辐射源（3）的控制装置（5）。

公开(公告)号：US07899636B2

公开(公告)日：2011-03-01

申请号：US11721368

申请日：2005-12-12

申请人： Bernardus Leonardus Gerardus Bakker

发明人： Bernardus Leonardus Gerardus Bakker

IPC分类号： G06F19/00 ,  G01J3/00

CPC分类号： G01N21/65 ,  G01J3/28 ,  G01N21/276 ,  G01N2021/1748 ,  G01N2201/1293

摘要： A method of calibrating an optical analysis system uses multivariate optical signal analysis. The method includes determining a parameter of a reference sample, and comparing the actually determined parameter with a reference parameter that represents a precise and real property of the reference sample. Based on the comparison, a calibration value is determined that is applicable to perform a calibration of the optical analysis system with respect to at least one compound or analyte of the reference sample. Parameters and reference parameters of a reference sample may refer to a concentration of an analyte dissolved in the sample, or to spectroscopic background signals that have to be taken into account when performing a spectral analysis based on optical signals obtained from the reference sample. Analyte-specific reference data is stored in a calibration unit of the optical analysis system and allows a high degree of automation of the calibration process.

摘要翻译： 校准光学分析系统的方法使用多变量光信号分析。 该方法包括确定参考样本的参数，以及将实际确定的参数与表示参考样本的精确和不动性的参考参数进行比较。 基于比较，确定适用于相对于参考样品的至少一种化合物或分析物执行光学分析系统的校准的校准值。 参考样品的参数和参考参数可以指溶解在样品中的分析物的浓度，或者基于从参考样品获得的光学信号进行光谱分析时必须考虑的光谱背景信号。 分析物特异性参考数据存储在光学分析系统的校准单元中，并允许校准过程的高度自动化。

公开(公告)号：US20080262324A1

公开(公告)日：2008-10-23

申请号：US11568743

申请日：2005-05-03

申请人： Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker ,  Gerald Lucassen ,  Hendrikus Antonius Cornelus Maria Compen ,  Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen

发明人： Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker ,  Gerald Lucassen ,  Hendrikus Antonius Cornelus Maria Compen ,  Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0062 ,  A61B5/68 ,  A61B5/6843

摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.

摘要翻译： 本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。 测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。 此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。 物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。 此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。 可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

公开(公告)号：US07252628B2

公开(公告)日：2007-08-07

申请号：US10538620

申请日：2003-11-18

申请人： Robbert Adrianus Maria Van Hal ,  Bernardus Leonardus Gerardus Bakker ,  Michiel Errit Roersma ,  Peter Bjerring

发明人： Robbert Adrianus Maria Van Hal ,  Bernardus Leonardus Gerardus Bakker ,  Michiel Errit Roersma ,  Peter Bjerring

IPC分类号： A61N5/00

CPC分类号： A61B18/203 ,  A61B2018/00011 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807

摘要： The invention relates to a device (1) for treating human skin by means of radiation. The device has a housing (5) with a radiation exit opening (13), a radiation source (9) which is accommodated in the housing, and a radiation path (15) between the radiation source and the radiation exit opening. A radiation filter (17) is provided in the radiation path. According to the invention the radiation filter (17) comprises water (23) which is in solid state at least during an initial phase of operation of the device (1). The water in solid state has an optical transmission spectrum which corresponds to the optical transmission spectrum of water in liquid state as present in the skin. As a result the water in solid state acts as an ideal filter for the IR light and near IR light, which would otherwise be absorbed by the water in the skin and cause unwanted heating of the skin. An additional advantage of the water in solid state is its relatively high heat absorbing capacity and its ability to cool the skin in case of direct thermal contact with the skin. In a particular embodiment the device (1) is an epilator for the removal of hairs from the human skin, the radiation source (9) being a flash lamp which generates light pulses having a high energy density and a broad optical spectrum.

摘要翻译： 本发明涉及一种用于通过辐射处理人体皮肤的装置（1）。 该装置具有壳体（5），其具有辐射出口（13），容纳在壳体中的辐射源（9）和辐射源与辐射出口之间的辐射路径（15）。 辐射过滤器（17）设置在辐射路径中。 根据本发明，辐射过滤器（17）包括至少在设备（1）的初始操作阶段期间处于固态的水（23）。 固态的水具有对应于存在于皮肤中的处于液态的水的光透射光谱的光透射光谱。 因此，固态的水作为IR光和近红外光的理想过滤器，否则会被皮肤中的水吸收并引起皮肤不必要的加热。 固体水中的另一个优点是其相对较高的吸热能力以及在与皮肤直接热接触的情况下冷却皮肤的能力。 在特定实施例中，装置（1）是用于从人体皮肤去除毛发的脱毛器，所述辐射源（9）是产生具有高能量密度和宽光谱的光脉冲的闪光灯。

公开(公告)号：US20100042348A1

公开(公告)日：2010-02-18

申请号：US11721368

申请日：2005-12-12

申请人： Bernardus Leonardus Gerardus BAKKER

发明人： Bernardus Leonardus Gerardus BAKKER

IPC分类号： G06F19/00 ,  G01J1/10 ,  G01J3/00

CPC分类号： G01N21/65 ,  G01J3/28 ,  G01N21/276 ,  G01N2021/1748 ,  G01N2201/1293

摘要： The invention provides a method of calibrating an optical analysis system that makes use of multivariate optical signal analysis allowing to realize cost-efficient and robust implementation of a spectral analysis of an optical signal. The calibration method makes use of determining a parameter of a reference sample by means of the optical analysis system and comparing the actually determined parameter with a reference parameter that represents a precise and real property of the reference sample. Based on this comparison a calibration value can be determined that is applicable to perform a calibration of the optical analysis system with respect to at least one compound or analyte of the reference sample. Parameters and reference parameters of a reference sample may refer to a concentration of an analyte dissolved in the sample, or to spectroscopic background signals that have to be taken into account when performing a spectral analysis based on optical signals obtained from the reference sample. Various different reference samples providing a reference with respect to different acquisition conditions and different analyte or compound concentrations can be universally used. Analyte-specific reference data is preferably stored in a calibration unit of the optical analysis system and allows a high degree of automation of the calibration process.

摘要翻译： 本发明提供了一种校准光学分析系统的方法，其利用多变量光信号分析，从而实现光信号的光谱分析的成本有效且鲁棒的实现。 校准方法利用通过光学分析系统确定参考样本的参数，并将实际确定的参数与表示参考样本的精确和不变性的参考参数进行比较。 基于该比较，可以确定适用于相对于参考样品的至少一种化合物或分析物执行光学分析系统的校准的校准值。 参考样品的参数和参考参数可以指溶解在样品中的分析物的浓度，或者基于从参考样品获得的光学信号进行光谱分析时必须考虑的光谱背景信号。 可以普遍使用提供关于不同采集条件和不同分析物或化合物浓度的参考的各种不同参考样品。 分析物特异性参考数据优选地存储在光学分析系统的校准单元中，并允许校准过程的高度自动化。

公开(公告)号：US20080215038A1

公开(公告)日：2008-09-04

申请号：US11996318

申请日：2006-07-21

申请人： Bernardus Leonardus Gerardus Bakker ,  Robbert Adrianus Maria Van Hal ,  Rieko Verhagen

发明人： Bernardus Leonardus Gerardus Bakker ,  Robbert Adrianus Maria Van Hal ,  Rieko Verhagen

IPC分类号： A61B18/18 ,  A61B17/50 ,  A61B19/00

CPC分类号： A61B18/203 ,  A61B18/20 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00904

摘要： The invention relates to a system and method for removing hair The system comprises a hair detection device and a hair-removing device (20). Since 3D information on hairs (32) is required, but due to the very dispersed presence of, e.g., human hairs (32) on skin (30), known detection devices are too slow, the invention provides a combination of two image sensors. A first image sensor (12) produces a first image, based on which a selected part is imaged with a second image sensor (14) that provides the required 3D position information with which the hair-removing device (20) can remove the hair Thus, optimum use may be made of both fast but less accurate image sensors, such as (2D) CCDs or CMOS sensors, and accurate but slow sensors such as 3D scanning sensors.

摘要翻译： 本发明涉及一种用于去毛发的系统和方法。该系统包括毛发检测装置和脱毛装置（20）。 由于需要关于毛发（32）的3D信息，而是由于例如皮肤（30）上的人类毛发（32）的非常分散的存在，已知的检测装置太慢，本发明提供了两个图像传感器的组合。 第一图像传感器（12）产生第一图像，基于该第一图像，通过第二图像传感器（14）对所选择的部分进行成像，第二图像传感器提供所需的3D位置信息，毛发去除装置（20）可以通过该位置信息去除头发。因此 ，可以最佳地使用诸如（2D）CCD或CMOS传感器的快速但不精确的图像传感器，以及诸如3D扫描传感器的精确但缓慢的传感器。

公开(公告)号：US07517344B2

公开(公告)日：2009-04-14

申请号：US10536242

申请日：2003-10-31

申请人： Robbert Adrianus Maria Van Hal ,  Bernardus Leonardus Gerardus Bakker ,  Paul Anton Josef Ackermans

发明人： Robbert Adrianus Maria Van Hal ,  Bernardus Leonardus Gerardus Bakker ,  Paul Anton Josef Ackermans

IPC分类号： A61B18/18

CPC分类号： A61B18/203 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/1807

摘要： The invention relates to a device (1) for treating human skin by means of radiation. The device comprises a housing (3) with a radiation exit opening (13). A radiation source (9) is accommodated in the housing. Radiation generated by the radiation source propagates from the radiation source towards the radiation exit opening via a radiation path (15) comprising a radiation filter having a predetermined transmission spectrum. According to the invention the radiation filter comprises a reflecting surface (23) via which the radiation propagating along the radiation path (15) is reflected. The reflecting surface has a coating which provides the reflecting surface with a reflection spectrum substantially matching the predetermined transmission spectrum. An advantage is that the reflection surface can be optimally and uniformly cooled, so that the heat generated as a result of the absorption of part of the radiation by the radiation filter can be effectively transmitted to a cooling system (25) of the device (1). In a particular embodiment the device (1) is an epilator for removing hairs from the human skin and the radiation source (9) is a flash lamp. The radiation path (15) is enclosed by a channel (17) having a bend (19) and having an inner wall (21) on which the reflecting surface (23) is provided.

摘要翻译： 本发明涉及一种用于通过辐射处理人体皮肤的装置（1）。 该装置包括具有辐射出口（13）的壳体（3）。 辐射源（9）容纳在壳体中。 由辐射源产生的辐射经由包括具有预定透射光谱的辐射滤光片的辐射路径（15）从辐射源向辐射出口开口传播。 根据本发明，辐射过滤器包括反射表面（23），沿着辐射路径（15）传播的辐射被反射。 反射面具有使反射面具有基本上与预定透射光谱相一致的反射光谱的涂层。 优点在于反射面可以被最佳和均匀地冷却，使得由辐射过滤器吸收一部分辐射而产生的热能被有效地传递到装置（1）的冷却系统（25） ）。 在特定实施例中，装置（1）是用于从人体皮肤去除头发的脱毛器，并且辐射源（9）是闪光灯。 辐射路径（15）由具有弯曲部（19）的通道（17）包围，并具有设置有反射面（23）的内壁（21）。

公开(公告)号：US07511812B2

公开(公告)日：2009-03-31

申请号：US11570133

申请日：2005-06-13

申请人： Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

发明人： Michael Cornelis Van Beek ,  Wouter Rensen ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

IPC分类号： G01J3/30

CPC分类号： G02B27/0025 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/28

摘要： A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of interest and for collecting return radiation from the volume of interest. After detection of the return radiation and generation of spectroscopic signals, a correction unit performs a compensation for aberrations of the spectroscopic signals introduced by the low cost objective lens. Since the aberrations of the objective lens strongly depend on the lateral distance of the volume of interest from the optical axis of the objective lens, the correction unit uses a correction table providing an assignment between correction values and various lateral positions of the volume of interest.

摘要翻译： 确定人的感兴趣体积的生物结构的性质的光谱系统包括用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的低成本物镜。 在检测到返回辐射和产生分光信号之后，校正单元对由低成本物镜引入的分光信号的像差进行补偿。 由于物镜的像差强烈地取决于物镜的光轴的感兴趣的体积的横向距离，所以校正单元使用校正表，该校正表提供校正值与感兴趣体积的各个横向位置之间的分配。

公开(公告)号：US20080062401A1

公开(公告)日：2008-03-13

申请号：US11570137

申请日：2005-06-22

申请人： Bernardus Leonardus Gerardus Bakker ,  Michael Cornelis Van Beek

发明人： Bernardus Leonardus Gerardus Bakker ,  Michael Cornelis Van Beek

IPC分类号： G01N21/25 ,  G02B6/42 ,  G06F19/00

CPC分类号： G01N21/65 ,  G01N2021/653 ,  G01N2021/655

摘要： The present invention provides a spectroscopic system for non invasive spectral analysis of substances or biological structures (114, 116) that are located in a plurality of various volumes of interest (110, 112). The inventive spectroscopic system makes use of a multiplicity of various probe heads (106, 108) that are connected to a base station (100) providing a spectroscopic light source (104) and spectroscopic analysis means (102) . By additionally implementing a coupling unit (132) the present invention allows to realize a spectroscopic analysis environment that makes spectroscopic analysis available in a variety of different locations, e.g. various rooms of a hospital.

摘要翻译： 本发明提供了一种用于对位于多个不同感兴趣体积（110,112）中的物质或生物结构（114,116）进行无创光谱分析的光谱系统。 本发明的光谱系统利用连接到提供分光光源（104）的基站（100）和光谱分析装置（102）的多个各种探头（106,108）。 通过附加地实现耦合单元（132），本发明允许实现使得光谱分析在各种不同位置（例如， 一间医院的各种房间。

公开(公告)号：US08406835B2

公开(公告)日：2013-03-26

申请号：US11568363

申请日：2005-02-14

申请人： Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

发明人： Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

IPC分类号： A61B5/1455 ,  A61B5/00 ,  G02B6/44

CPC分类号： A61B5/0059 ,  A61B5/489 ,  A61B2562/0242

摘要： A spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient is described. The spectroscopic system comprises: a probe head having an objective for directing an excitation beam into the volume of interest and for collecting return radiation from the volume of interest; a base station having a spectroscopic analysis unit and a power supply; and a cable connecting the probe head and the base station for transmission of the return radiation from the probe head to the base station and for providing the probe head with power from the power supply of the base station.

摘要翻译： 描述了用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。 分光系统包括：探头，其具有用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的目标; 具有光谱分析单元和电源的基站; 以及连接探头和基站的电缆，用于将返回辐射从探头传输到基站，并为探头提供来自基站的电源的电力。