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公开(公告)号：US20150336914A1
公开(公告)日：2015-11-26
申请号：US14817175
申请日：2015-08-03
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： C07D277/68
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
摘要翻译： 本发明提供游离形式或药学上可接受的盐形式的式（I）化合物，其制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US08933108B2
公开(公告)日：2015-01-13
申请号：US13603990
申请日：2012-09-05
申请人： Jun Cao , Bernhard Erb , Robin Alec Fairhurst , Arnaud Grandeury , Shinji Hatakeyama , Magdalena Koziczak-Holbro , Xinzhong Lai , Philipp Lustenberger , Bernd Riebesehl , Nicola Tufilli , Thomas Ullrich , Xiang Wu , Jianguang Zhou
发明人： Jun Cao , Bernhard Erb , Robin Alec Fairhurst , Arnaud Grandeury , Shinji Hatakeyama , Magdalena Koziczak-Holbro , Xinzhong Lai , Philipp Lustenberger , Bernd Riebesehl , Nicola Tufilli , Thomas Ullrich , Xiang Wu , Jianguang Zhou
IPC分类号： A01N43/78 , A61K31/425 , C07D277/62 , C07D277/68 , C07D327/04 , C07D343/00 , C07D327/10 , C07D339/02 , C07D341/00 , C07D409/00 , C07D411/00 , C07D495/00 , C07D497/00 , A61K31/428 , A61K45/06
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
摘要翻译： 本发明提供游离形式或药学上可接受的盐形式的式（I）化合物，其制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20130245080A1
公开(公告)日：2013-09-19
申请号：US13603990
申请日：2012-09-05
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： A61K31/428 , A61K45/06 , C07D277/68
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
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公开(公告)号：US20160075670A1
公开(公告)日：2016-03-17
申请号：US14947458
申请日：2015-11-20
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： C07D277/68 , C07C53/10
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
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公开(公告)号：US20150094346A1
公开(公告)日：2015-04-02
申请号：US14566021
申请日：2014-12-10
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： C07D277/68 , A61K31/167 , A61K31/428
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
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