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公开(公告)号：US08933108B2
公开(公告)日：2015-01-13
申请号：US13603990
申请日：2012-09-05
申请人： Jun Cao , Bernhard Erb , Robin Alec Fairhurst , Arnaud Grandeury , Shinji Hatakeyama , Magdalena Koziczak-Holbro , Xinzhong Lai , Philipp Lustenberger , Bernd Riebesehl , Nicola Tufilli , Thomas Ullrich , Xiang Wu , Jianguang Zhou
发明人： Jun Cao , Bernhard Erb , Robin Alec Fairhurst , Arnaud Grandeury , Shinji Hatakeyama , Magdalena Koziczak-Holbro , Xinzhong Lai , Philipp Lustenberger , Bernd Riebesehl , Nicola Tufilli , Thomas Ullrich , Xiang Wu , Jianguang Zhou
IPC分类号： A01N43/78 , A61K31/425 , C07D277/62 , C07D277/68 , C07D327/04 , C07D343/00 , C07D327/10 , C07D339/02 , C07D341/00 , C07D409/00 , C07D411/00 , C07D495/00 , C07D497/00 , A61K31/428 , A61K45/06
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
摘要翻译： 本发明提供游离形式或药学上可接受的盐形式的式（I）化合物，其制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US08740466B2
公开(公告)日：2014-06-03
申请号：US13818656
申请日：2011-09-29
申请人： Jörg Schwarzbich , Thomas Ullrich
发明人： Jörg Schwarzbich , Thomas Ullrich
IPC分类号： F16C43/04
CPC分类号： F16C33/583 , F16C19/166 , F16C27/04 , F16C33/586 , F16C33/588 , F16C35/063
摘要： A roller bearing for a shaft that has a cylindrical peripheral surface, the bearing including a race (12) to be fitted onto the shaft, and roller bodies (16) arranged to roll on the race (12), the race (12) having a polygonal internal cross-section, so that it engages the peripheral surface of the shaft only in the vicinity of the center of each side (28) of the polygon.
摘要翻译： 一种用于具有圆柱形外周表面的轴的滚子轴承，所述轴承包括装配到所述轴上的座圈（12）和布置成在所述座圈（12）上滚动的滚子体（16），所述座圈（12）具有 多边形的内部横截面，使得其仅在多边形的每侧（28）的中心附近接合轴的外周表面。
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公开(公告)号：US20060147996A1
公开(公告)日：2006-07-06
申请号：US11284469
申请日：2005-11-22
申请人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
发明人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
CPC分类号： C12Q1/686 , B01J19/0046 , B01J2219/00457 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/5082 , B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0636 , C12Q1/6837 , C40B40/06 , C40B40/10 , C12Q2537/162 , C12Q2537/161 , C12Q2531/107 , C12Q2525/186
摘要： The invention relates to a holding device for substance libraries which can be used, more particularly, for the detection of target molecules with the aid of substance libraries. Said device comprises: (i) a holder for a substance library carrier; (ii) a substance library carrier, which can be fixed to the holder; and (iii) a detection area applied to the substance library carrier, whereon a substance library is immobilized; and wherein at least one substance library carrier can be introduced into a laboratory reaction vessel.
摘要翻译： 本发明涉及用于物质文库的保持装置，更具体地说，可用于借助物质文库检测靶分子。 所述装置包括：（i）用于物质库载体的保持器; （ii）可以固定在保持器上的物质库载体; 和（iii）应用于物质文库载体的检测区域，其中固定有物质文库; 并且其中可以将至少一种物质文库载体引入实验室反应容器中。
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公开(公告)号：US08040494B2
公开(公告)日：2011-10-18
申请号：US12092422
申请日：2006-11-06
IPC分类号： G06K9/74
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or the second surface. The invention also relates to corresponding methods for the detection of particles, comprising positioning a sample supposed to comprise one or more species of particles to be detected in a reaction chamber, displacing at least a part of the sample within the reaction chamber via the one or more displacers; and detecting/determining a value indicative for the presence and/or number of one or more species of particles.
摘要翻译： 本发明涉及用于定性和/或定量检测颗粒的装置和方法。 特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器， 其中所述第一表面和所述第二表面之间的距离可以经由所述一个或多个位移器在所述第一表面和/或所述第二表面的表面区域的至少一个或多个部分中是可变的。 本发明还涉及用于检测颗粒的相应方法，包括将假定包含待检测的一种或多种待检测颗粒的样品定位在反应室中，通过一个或多个反应室置换反应室内的至少一部分样品 更多的置换器 以及检测/确定指示一种或多种粒子的存在和/或数量的值。
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公开(公告)号：US20110110392A1
公开(公告)日：2011-05-12
申请号：US13003656
申请日：2009-07-15
申请人： Wolfgang Rösch , Thomas Ullrich
发明人： Wolfgang Rösch , Thomas Ullrich
CPC分类号： F16H59/70 , F16H63/38 , F16H2061/283
摘要： A method of calibrating a position sensor in an automotive transmission having a transmission housing having mounted therein a casing (10) for the position sensor which includes a pressure member (14) movably supported in the casing (10), and an electrical displacement sensor (38) actuated by the pressure member (14) for measuring the position of the pressure member (14) relative to the casing (10), such that, after the casing (10) of the position sensor has been mounted in the transmission housing, the displacement sensor (38) is used for performing at least one calibration measurement for at least one gear position, and, for each gear position to be detected, a tolerance range for the corresponding measurement value of the displacement sensor is defined on the basis of the result of the calibration measurement.
摘要翻译： 一种校准汽车变速器中的位置传感器的方法，其具有安装有用于位置传感器的壳体（10）的变速器壳体，该壳体包括可移动地支撑在壳体（10）中的压力构件（14）和电位移传感器 38），用于测量压力构件（14）相对于壳体（10）的位置的压力构件（14），使得在位置传感器的壳体（10）已经安装在变速器壳体中之后， 位移传感器（38）用于对至少一个档位执行至少一个校准测量，并且对于要检测的每个档位，基于位移传感器的对应测量值的公差范围 校准测量的结果。
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公开(公告)号：US20090079963A1
公开(公告)日：2009-03-26
申请号：US12092422
申请日：2006-11-06
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or the second surface. The invention also relates to corresponding methods for the detection of particles, comprising positioning a sample supposed to comprise one or more species of particles to be detected in a reaction chamber, displacing at least a part of the sample within the reaction chamber via the one or more displacers; and detecting/determining a value indicative for the presence and/or number of one or more species of particles.
摘要翻译： 本发明涉及用于定性和/或定量检测颗粒的装置和方法。 特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器， 其中所述第一表面和所述第二表面之间的距离可以经由所述一个或多个位移器在所述第一表面和/或所述第二表面的表面区域的至少一个或多个部分中是可变的。 本发明还涉及用于检测颗粒的相应方法，包括将假定包含待检测的一种或多种待检测颗粒的样品定位在反应室中，通过一个或多个反应室置换反应室内的至少一部分样品 更多的置换器 以及检测/确定指示一种或多种粒子的存在和/或数量的值。
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公开(公告)号：US20060078929A1
公开(公告)日：2006-04-13
申请号：US11241671
申请日：2005-09-30
申请人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G01N21/4738 , G01N21/59
摘要： The present invention relates to a device for the amplification and for the detection of nucleic acids comprising a temperature controlling and/or regulating unit; a reaction chamber containing a support with a detection area, on which a compound library is immobilized, wherein the temperature in the reaction chamber can be controlled and/or regulated by means of the temperature controlling and regulating unit; and an optical system, by means of which the time-dependent behavior of precipitate formations on the detection area is detectable. Methods of using the device are also disclosed.
摘要翻译： 本发明涉及用于扩增和检测包含温度控制和/或调节单元的核酸的装置; 包含具有检测区域的载体的反应室，其上固定有化合物文库，其中可以通过温度控制和调节单元来控制和/或调节反应室中的温度; 以及光学系统，通过该光学系统可以检测出沉积物在检测区域上的时间依赖性。 还公开了使用该装置的方法。
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公开(公告)号：US09925536B2
公开(公告)日：2018-03-27
申请号：US12670088
申请日：2008-07-23
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
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公开(公告)号：US20160237482A1
公开(公告)日：2016-08-18
申请号：US14580137
申请日：2014-12-22
申请人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/68 , G01N21/64
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , B01L2400/0487 , C12Q1/6825 , C12Q1/6832 , G01N21/6428 , G01N33/54306 , G01N33/54366 , G01N33/58 , G01N33/6845 , G01N35/00 , G01N2021/6439 , Y10T436/143333 , C12Q2563/107 , C12Q2565/102 , C12Q2565/601 , C12Q2565/629
摘要： The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
摘要翻译： 本发明涉及用于检测探针和靶分子之间特异性相互作用的装置和方法。 特别地，本发明涉及用于定性和/或定量检测靶的方法，包括：将含有靶的样品引入形成在器件的第一表面和器件的第二表面之间的反应室中，反应室优选位于 与第一表面相对，其中第一和第二表面之间的距离是可变的; 并检测目标。
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公开(公告)号：US08916348B2
公开(公告)日：2014-12-23
申请号：US11593021
申请日：2006-11-06
申请人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , B01L2400/0487 , C12Q1/6825 , C12Q1/6832 , G01N21/6428 , G01N33/54306 , G01N33/54366 , G01N33/58 , G01N33/6845 , G01N35/00 , G01N2021/6439 , Y10T436/143333 , C12Q2563/107 , C12Q2565/102 , C12Q2565/601 , C12Q2565/629
摘要： The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
摘要翻译： 本发明涉及用于检测探针和靶分子之间特异性相互作用的装置和方法。 特别地，本发明涉及用于定性和/或定量检测靶的方法，包括：将含有靶的样品引入形成在器件的第一表面和器件的第二表面之间的反应室中，反应室优选位于 与第一表面相对，其中第一和第二表面之间的距离是可变的; 并检测目标。
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