公开(公告)号：US4126669A

公开(公告)日：1978-11-21

申请号：US767197

申请日：1977-02-09

申请人： Ulf S. E. Rothman ,  Bernt J. Lindberg

发明人： Ulf S. E. Rothman ,  Bernt J. Lindberg

IPC分类号： A61K51/12 ,  C08B31/00 ,  A61K29/00 ,  A61K43/00

CPC分类号： C08B31/003 ,  A61K51/1258 ,  A61K2123/00

摘要： A diagnostic agent for intravascular administration into blood vessels composed of radioactively labelled particles suspended in a physiologically acceptable aqueous liquid, said particles having a size so selected that they clog fine blood vessels having a diameter within the range 5 - 300 .mu.m, said particles consisting of a three-dimensional, water-insoluble, hydrophilic, swellable, cross-linked network of polysaccharide substances, and the method of using this diagnostic agent.

公开(公告)号：US4124705A

公开(公告)日：1978-11-07

申请号：US583217

申请日：1975-06-02

申请人： Ulf S. E. Rothman ,  Bernt J. Lindberg

发明人： Ulf S. E. Rothman ,  Bernt J. Lindberg

IPC分类号： A61K49/04 ,  A61K9/107 ,  A61K9/127 ,  A61K9/16 ,  A61K31/715 ,  A61K47/36 ,  A61K49/00 ,  C08B31/00 ,  A61K29/02

CPC分类号： A61K49/0004 ,  A61K9/1652 ,  C08B31/006

摘要： The present invention relates to an agent for intravascular administration, said agent consisting of a suspension of minute polysaccharide particles having a size such that subsequent to being administered intravascularly, they block the finer blood vessels of the body and a diagnostic agent.

摘要翻译： 本发明涉及一种用于血管内施用的药剂，所述药剂由微量多糖颗粒的悬浮液组成，所述微小多糖颗粒的悬浮液具有这样的尺寸，使得在血管内施用之后，它们阻断身体更细的血管和诊断剂。

公开(公告)号：US4985233A

公开(公告)日：1991-01-15

申请号：US793899

申请日：1985-11-01

申请人： Jo Klaveness ,  Trond Jacobsen ,  Bernt J. Lindberg

发明人： Jo Klaveness ,  Trond Jacobsen ,  Bernt J. Lindberg

IPC分类号： A61K49/00 ,  A61K49/06 ,  A61K49/18

CPC分类号： A61K49/128 ,  A61K49/06 ,  A61K49/1821 ,  Y10S436/806 ,  Y10T436/24

摘要： A paramagnetic metal species-containing diagnostic agent is disclosed which comprises a non-radioactive paramagnetic metal species and, as a carrier therefor, a physiologically tolerable, water-insoluble, hydroxyl group-containing, particulate macromolecular product consisting essentially of at least one polymeric or polymerized carbohydrate or polymerized sugar alcohol or derivative thereof.

摘要翻译： 公开了含顺磁性金属物质的诊断剂，其包含非放射性顺磁性金属物质，并且作为其载体，具有生理上可耐受的，水不溶性的含羟基的颗粒状大分子产物，其主要由至少一种聚合物或 聚合的碳水化合物或聚合的糖醇或其衍生物。

公开(公告)号：US3980770A

公开(公告)日：1976-09-14

申请号：US529987

申请日：1974-12-05

申请人： Bjorn G.-A. Ingelman ,  Bernt J. Lindberg ,  Jan G. Rosengren ,  Dag E. S. Campbell

发明人： Bjorn G.-A. Ingelman ,  Bernt J. Lindberg ,  Jan G. Rosengren ,  Dag E. S. Campbell

IPC分类号： A61K31/785 ,  B01J41/14 ,  C08G59/50 ,  A61K31/74 ,  A01N9/20 ,  A01N9/24

CPC分类号： B01J41/14 ,  A61K31/785 ,  C08G59/5033

摘要： A pharmaceutical product containing amino groups, which product:A. is comprised of residues of one or more diamines of the general formulaH.sub.2 N.CH.sub.2. phenylene.CH.sub.2.NH.sub.2 (I)which residues are interconnected by bridges between the residues to form a three-dimensional network, the bridges being bound to nitrogen atoms in the residues (I) and comprise straight or branched aliphatic, saturated hydrocarbon chains substituted with one or more hydroxyl groups and containing 3-30 carbon atoms, preferably 3-16 carbon atoms and which are optionally broken by one or more oxygen atoms, the amino groups being present in a free form or in the form of (the cation portion of) a non-toxic salt, andB. is insoluble in water or other solvents, but capable of swelling in water to gel form, 1 g of the dry product in the form of an HCl salt in the presence of water swelling to at least 5 ml and to at most 50 ml, preferably to at least 5 ml and to at most 25 ml, andC. is in grain form having a particle size substantially within the range of 1 to 1000 .mu., preferably 10 to 800 .mu., andD. has an ion-exchange capacity within the range of 0.2 to 1 milliequivalents chloride ions, preferably 0.3 to 0.9 milliequivalents chloride ions, per 100 mg of dry gel,A method for its preparation and use for lowering the cholesterol content of the blood of mammals and birds.

摘要翻译： 含氨基的药物产品：