公开(公告)号：US20100130471A1

公开(公告)日：2010-05-27

申请号：US12450619

申请日：2008-04-04

Applicant: John J. Baldwin ,  Salvacion Cacatian ,  David Claremon ,  Lawrence W. Dillard ,  Patrick T. Flaherty ,  Bahman Ghavimi-Alagha ,  Damiamo Ghirlanda ,  Xiaoping Hou ,  Alexey V. Ishebenko ,  Lara S. Kallander ,  Beth A. Knapp-Reed ,  Brian Lawhorn ,  Qing Lu ,  Gerard McGeehan ,  Simon Semus ,  Robert D. Simpson ,  Suresh B. Singh ,  Lamont R. Terrell ,  Colin Tice ,  Tritin Tran ,  Zhenrong Xu ,  Jing Yuan ,  Jing Zhang ,  Wei Zhao

Inventor： John J. Baldwin ,  Salvacion Cacatian ,  David Claremon ,  Lawrence W. Dillard ,  Patrick T. Flaherty ,  Bahman Ghavimi-Alagha ,  Damiamo Ghirlanda ,  Xiaoping Hou ,  Alexey V. Ishebenko ,  Lara S. Kallander ,  Beth A. Knapp-Reed ,  Brian Lawhorn ,  Qing Lu ,  Gerard McGeehan ,  Simon Semus ,  Robert D. Simpson ,  Suresh B. Singh ,  Lamont R. Terrell ,  Colin Tice ,  Tritin Tran ,  Zhenrong Xu ,  Jing Yuan ,  Jing Zhang ,  Wei Zhao

IPC: A61K31/445 ,  A61K31/554 ,  A61K31/55 ,  A61K31/551 ,  A61K31/549 ,  A61K31/5377 ,  A61K31/5375 ,  A61K31/4545 ,  C07D417/12 ,  C07D265/30 ,  C07D401/06 ,  C07D401/10 ,  C07D211/34 ,  A61P25/00 ,  A61P9/12 ,  A61P9/10

CPC classification number: C07D401/06 ,  C07D211/22 ,  C07D265/30

Abstract: Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.

Abstract translation: 描述了结合天冬氨酸蛋白酶抑制其活性的化合物。 它们可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。 还描述了本文所述化合物在有需要的受试者中改善或治疗天冬氨酸蛋白酶相关病症的方法。