公开(公告)号：US06405074B1

公开(公告)日：2002-06-11

申请号：US09097931

申请日：1998-06-16

Applicant: Bhaskar Banerjee

Inventor： Bhaskar Banerjee

IPC: A61B500

CPC classification number: A61B5/0071 ,  A61B5/0084

Abstract: Apparatus and methods especially useful for detection of cancer using cellular autofluorescence are described. In one embodiment, the apparatus includes a source of white light which produces a beam of light transmitted to a tissue via one group of optic fibers in a two-way fiber optic bundle. The two-way fiber optic bundle may be passed through a conventional endoscope. The beam of light excites the tissue and results in an emission of cellular autofluorescence at a wavelength of about 330 nm. A light sample from the tissue is directed back through the two-way fiber optic bundle and then passes through a photodetector. The photodetector produces a signal, representative of the intensity of cellular autofluorescence, which can be passed to a monitor as a wave form or meter response. The apparatus may further comprise a charge-coupled device and video imaging technology to produce real time video images of tissue being examined.

Abstract translation: 描述了特别适用于使用细胞自体荧光检测癌症的装置和方法。 在一个实施例中，该装置包括白光源，其产生通过双向光纤束中的一组光纤传输到组织的光束。 双向光纤束可以通过常规内窥镜。 光束激发组织并导致波长为约330nm的细胞自发荧光的发射。 来自组织的轻质样品被引导回穿过双向光纤束，然后通过光电检测器。 光电检测器产生代表蜂窝自发荧光强度的信号，其可以作为波形或仪表响应传递到监视器。 该装置还可以包括电荷耦合器件和视频成像技术，以产生被检查的组织的实时视频图像。

公开(公告)号：US06405070B1

公开(公告)日：2002-06-11

申请号：US09522557

申请日：2000-03-10

Applicant: Bhaskar Banerjee

Inventor： Bhaskar Banerjee

IPC: A61B500

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4233 ,  A61B5/4331 ,  A61B5/4375 ,  A61B5/441 ,  G01N21/6456 ,  G01N33/5005 ,  G01N33/533

Abstract: Apparatus and methods especially useful for detection of cancer using cellular, Tryptophan-associated autofluorescence are described. The apparatus includes a light source to produce a beam of light transmitted to a tissue via a two-way fiber optic bundle which, in one embodiment, is passed through a conventional endoscope. The light beam excites the tissue, resulting in an emission of primarily cellular autofluorescence at a wavelength of about 330 nm. Light from the tissue is directed back through the fiber optic bundle and passes through a photodetector. The photodetector produces a signal, representative of the intensity of the Tryptophan-associated autofluorescence.

Abstract translation: 描述了特别适用于使用细胞色氨酸相关自身荧光检测癌症的装置和方法。 该装置包括光源，以通过双向光纤束产生透射到组织的光束，该双向光纤束在一个实施例中通过常规内窥镜。 光束激发组织，导致波长约330nm的主要细胞自发荧光的发射。 来自组织的光被引导回穿过光纤束并通过光电检测器。 光电检测器产生代表色氨酸相关自发荧光强度的信号。