公开(公告)号：US20240002391A1

公开(公告)日：2024-01-04

申请号：US18340543

申请日：2023-06-23

申请人： BioSplice Therapeutics, Inc.

发明人： Gopi Kumar Mittapalli ,  Chi Ching Mak ,  Lewis Daniel Turner ,  Brian Joseph Hofilena ,  Ramkrishna Reddy Vakiti ,  Brian Walter Eastman ,  David Mark Wallace

IPC分类号： C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

公开(公告)号：US11548872B2

公开(公告)日：2023-01-10

申请号：US17155577

申请日：2021-01-22

申请人： BioSplice Therapeutics, Inc.

发明人： Sunil Kumar KC ,  Chi Ching Mak ,  Brian Walter Eastman ,  Jianguo Cao ,  Venkataiah Bollu ,  Gopi Kumar Mittapalli ,  Chandramouli Chiruta

IPC分类号： A61K31/4725 ,  C07D401/14 ,  C07D471/10 ,  C07D417/04 ,  C07D413/14 ,  C07D405/14 ,  C07D409/14 ,  C07D487/08 ,  C07D401/04 ,  C07D491/048 ,  C07D417/14 ,  C07D487/04 ,  C07D471/08

摘要： Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：US20230312605A1

公开(公告)日：2023-10-05

申请号：US17964489

申请日：2022-10-12

申请人： BioSplice Therapeutics, Inc.

发明人： Gopi Kumar Mittapalli ,  Sunil Kumar KC ,  Chi Ching Mak ,  Brian Joseph Hofilena ,  Lewis Daniel Turner ,  Brian Walter Eastman ,  Ramkrishna Reddy Vakiti ,  Joseph Timothy Marakovits

IPC分类号： C07D519/00 ,  C07D487/04

CPC分类号： C07D519/00 ,  C07D487/04 ,  C07B2200/05

摘要： Pyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of pyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer’s disease, diabetes, viral infections, and osteoarthritis).

公开(公告)号：US20230167133A1

公开(公告)日：2023-06-01

申请号：US17964470

申请日：2022-10-12

申请人： BioSplice Therapeutics, Inc.

发明人： Gopi Kumar Mittapalli ,  Sunil Kumar KC ,  Chi Ching Mak ,  Brian Joseph Hofilena ,  Chandramouli Chiruta ,  Ramkrishna Reddy Vakiti ,  Brian Walter Eastman ,  Joseph Timothy Marakovits ,  Lewis Daniel Turner

IPC分类号： C07D519/00 ,  C07D487/04

CPC分类号： C07D519/00 ,  C07D487/04 ,  C07B2200/05

摘要： 7H-Pyrrolo[2,3-d]pyrimidine compound for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

公开(公告)号：US11560378B2

公开(公告)日：2023-01-24

申请号：US17108544

申请日：2020-12-01

申请人： BioSplice Therapeutics, Inc.

发明人： John Hood ,  David Mark Wallace ,  Sunil Kumar KC ,  Yusuf Yazici ,  Christopher Swearingen ,  Luis A Dellamary

IPC分类号： C07D513/02 ,  C07D515/02 ,  A61K31/44 ,  C07D471/04 ,  A61K31/444 ,  A61P19/02 ,  A61P29/00 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K9/00

摘要： Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.

公开(公告)号：US20220402921A1

公开(公告)日：2022-12-22

申请号：US17138098

申请日：2020-12-30

申请人： BioSplice Therapeutics, Inc.

发明人： Sunil Kumar KC ,  Chi Ching Mak ,  Gopi Kumar Mittapalli ,  Brian Joseph Hofilena ,  Brian Walter Eastman ,  Jianguo Cao ,  Chandramouli Chiruta ,  Venkataiah Bollu

IPC分类号： C07D487/04 ,  C07D403/04 ,  C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  A61P19/04

摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, Darier's disease, scleroderma, cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

公开(公告)号：US20230139639A1

公开(公告)日：2023-05-04

申请号：US17873818

申请日：2022-07-26

申请人： BioSplice Therapeutics, Inc.

发明人： Luis A. Dellamary

IPC分类号： A61K31/444 ,  A61K9/00 ,  A61K9/10 ,  A61K31/437 ,  A61P19/02 ,  A61K47/02 ,  A61K47/38

摘要： Provided are single-dose, ready-to-use formulations and methods for preparing the formulations that include a compound of Formula (I) including pharmaceutically acceptable salts and amorphous and polymorph forms thereof.

公开(公告)号：US20230047396A1

公开(公告)日：2023-02-16

申请号：US17346808

申请日：2021-06-14

申请人： BioSplice Therapeutics, Inc.

发明人： John Hood ,  Sunil Kumar KC

IPC分类号： C07D401/14 ,  A61K45/06 ,  C07D401/10 ,  C07D405/14 ,  C07D413/12 ,  C07D401/04 ,  C07D401/12 ,  A61K31/416

摘要： Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：US20220087917A1

公开(公告)日：2022-03-24

申请号：US17362177

申请日：2021-06-29

申请人： BioSplice Therapeutics, Inc.

发明人： John Hood ,  Sunil Kumar KC ,  Osman Kibar ,  Charlene F. Barroga

IPC分类号： A61K8/49 ,  A61K8/35 ,  A61K8/41 ,  A61K8/69 ,  A61K8/70 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08

摘要： The present disclosure relates to compounds, cosmetic or dermopharmaceutical compositions comprising the same, and methods for using the compounds or compositions for treating, protecting, and/or improving the condition and/or aesthetic appearance of skin, for example, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, or improving the appearance of fine lines and/or or wrinkles of skin comprising application of the compounds or compositions disclosed.

公开(公告)号：US20220024914A1

公开(公告)日：2022-01-27

申请号：US17205558

申请日：2021-03-18

申请人： BioSplice Therapeutics, Inc.

发明人： Sunil Kumar KC

IPC分类号： C07D471/04

摘要： Provided herein is a synthetic process for preparing a compound of Formula (1). The disclosure also provides useful intermediates and salts, amorphous and polymorph forms of the compound of Formula (1). These compounds are useful for various disease including cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, and osteoarthritis as well as Wnt-related diseases.