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公开(公告)号:US08163885B2
公开(公告)日:2012-04-24
申请号:US12597357
申请日:2009-05-06
申请人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
发明人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
IPC分类号: C07K16/00 , A61K39/395
CPC分类号: C07K16/249 , C07K16/464 , C07K2317/34
摘要: The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.
摘要翻译: 本发明提供可用于人类治疗应用的人源化抗人IFN-α单克隆抗体。 优选的抗体是鼠抗体ACO-1和ACO-2的人源化形式,以及它们的变体。
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公开(公告)号:US08361463B2
公开(公告)日:2013-01-29
申请号:US13363609
申请日:2012-02-01
申请人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
发明人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
IPC分类号: A61K39/395 , A61K38/00 , C07K16/00 , C12P21/08
CPC分类号: C07K16/249 , C07K16/464 , C07K2317/34
摘要: The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.
摘要翻译: 本发明提供可用于人类治疗应用的人源化抗人IFN-α单克隆抗体。 优选的抗体是鼠抗体ACO-1和ACO-2的人源化形式,以及它们的变体。
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公开(公告)号:US20120195888A1
公开(公告)日:2012-08-02
申请号:US13363609
申请日:2012-02-01
申请人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
发明人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
IPC分类号: A61K39/395 , A61P37/06 , A61P29/00 , A61P17/06
CPC分类号: C07K16/249 , C07K16/464 , C07K2317/34
摘要: The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.
摘要翻译: 本发明提供可用于人类治疗应用的人源化抗人IFN-α单克隆抗体。 优选的抗体是鼠抗体ACO-1和ACO-2的人源化形式,以及它们的变体。
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公开(公告)号:US09737612B2
公开(公告)日:2017-08-22
申请号:US13982617
申请日:2012-03-01
申请人: Mette Dahl Andersen , Peder Lisby Noerby , Kristian Kjaergaard , Albrecht Gruhler , Susanne Nedergaard Grell , Jens Buchardt , Henrik Sune Andersen , Soeren Padkjaer , Jesper Kastrup , Katarina Haakansson , Lars Hornum , Birgitte Friedrichsen , Dorrit Baunsgaard
发明人: Mette Dahl Andersen , Peder Lisby Noerby , Kristian Kjaergaard , Albrecht Gruhler , Susanne Nedergaard Grell , Jens Buchardt , Henrik Sune Andersen , Soeren Padkjaer , Jesper Kastrup , Katarina Haakansson , Lars Hornum , Birgitte Friedrichsen , Dorrit Baunsgaard
CPC分类号: A61K47/6803 , A61K47/545 , A61K2039/505 , C07K14/70578 , C07K16/2863 , C07K16/2878 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要: The present disclosure relates to treatment of inflammatory diseases. In particular, the present disclosure relates to antagonistic DR3 ligands useful for treating inflammatory diseases.
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公开(公告)号:US20130330360A1
公开(公告)日:2013-12-12
申请号:US13982617
申请日:2012-03-01
申请人: Mette Dahl Andersen , Peder Lisby Noerby , Kristian Kjaergaard , Albrecht Gruhler , Susanne Nedergaard Grell , Jens Buchardt , Henrik Sune Andersen , Soeren Padkjaer , Jesper Kastrup , Katarina Haakansson , Lars Hornum , Birgitte Friedrichsen , Dorrit Baunsgaard
发明人: Mette Dahl Andersen , Peder Lisby Noerby , Kristian Kjaergaard , Albrecht Gruhler , Susanne Nedergaard Grell , Jens Buchardt , Henrik Sune Andersen , Soeren Padkjaer , Jesper Kastrup , Katarina Haakansson , Lars Hornum , Birgitte Friedrichsen , Dorrit Baunsgaard
IPC分类号: C07K16/28
CPC分类号: A61K47/6803 , A61K47/545 , A61K2039/505 , C07K14/70578 , C07K16/2863 , C07K16/2878 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要: The present disclosure relates to treatment of inflammatory diseases. In particular, the present disclosure relates to antagonistic DR3 ligands useful for treating inflammatory diseases.
摘要翻译: 本公开涉及炎性疾病的治疗。 特别地,本公开涉及用于治疗炎性疾病的拮抗性DR3配体。
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公开(公告)号:US20130164299A1
公开(公告)日:2013-06-27
申请号:US13807505
申请日:2011-06-28
申请人: Petrus Johannes Louis Spee , Peter Andreas Nicolai Reumert Wagtmann , Stefan Zahn , Elisabeth D. Galsgaard , Birgitte Friedrichsen , Véronique Braud
发明人: Petrus Johannes Louis Spee , Peter Andreas Nicolai Reumert Wagtmann , Stefan Zahn , Elisabeth D. Galsgaard , Birgitte Friedrichsen , Véronique Braud
IPC分类号: C07K16/18
CPC分类号: C07K16/2851 , C07K16/18 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6872
摘要: The present invention relates to monoclonal antibodies that are capable of specifically binding to lectin-like transcript 1 (LLT1), to polynucleotides encoding such antibodies and to cells that express such antibodies. Antibodies of the invention have utility in the treatment of autoimmune diseases and cancer, in which LLT1- and CD161-expressing cells play a role in disease pathogenesis.
摘要翻译: 本发明涉及能够特异性结合凝集素样转录物1(LLT1)的单克隆抗体,编码这种抗体的多核苷酸和表达这种抗体的细胞。 本发明的抗体可用于治疗自身免疫疾病和癌症,其中表达LLT1和CD161的细胞在疾病发病中起作用。
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公开(公告)号:US20110213125A1
公开(公告)日:2011-09-01
申请号:US12597357
申请日:2009-05-06
申请人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
发明人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
IPC分类号: C07K16/24
CPC分类号: C07K16/249 , C07K16/464 , C07K2317/34
摘要: The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.
摘要翻译: 本发明提供可用于人类治疗应用的人源化抗人IFN-α单克隆抗体。 优选的抗体是鼠抗体ACO-1和ACO-2的人源化形式,以及它们的变体。
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公开(公告)号:US09127052B2
公开(公告)日:2015-09-08
申请号:US13807505
申请日:2011-06-28
申请人: Petrus Johannes Louis Spee , Peter Andreas Nicolai Reumert Wagtmann , Stefan Zahn , Elisabeth D. Galsgaard , Birgitte Friedrichsen , Véronique Braud
发明人: Petrus Johannes Louis Spee , Peter Andreas Nicolai Reumert Wagtmann , Stefan Zahn , Elisabeth D. Galsgaard , Birgitte Friedrichsen , Véronique Braud
CPC分类号: C07K16/2851 , C07K16/18 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6872
摘要: The present invention relates to monoclonal antibodies that are capable of specifically binding to lectin-like transcript 1 (LLT1), to polynucleotides encoding such antibodies and to cells that express such antibodies. Antibodies of the invention have utility in the treatment of autoimmune diseases and cancer, in which LLT1-and CD161-expressing cells play a role in disease pathogenesis.
摘要翻译: 本发明涉及能够特异性结合凝集素样转录物1(LLT1)的单克隆抗体,编码这种抗体的多核苷酸和表达这种抗体的细胞。 本发明的抗体可用于治疗自身免疫疾病和癌症,其中表达LLT1和CD161的细胞在疾病发病中起作用。
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公开(公告)号:US08658771B2
公开(公告)日:2014-02-25
申请号:US13719536
申请日:2012-12-19
申请人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen , Jan Fleckner
发明人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen , Jan Fleckner
IPC分类号: C07K16/00 , A61K39/395
CPC分类号: C07K16/249 , C07K16/464 , C07K2317/34
摘要: The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.
摘要翻译: 本发明提供可用于人类治疗应用的人源化抗人IFN-α单克隆抗体。 优选的抗体是鼠抗体ACO-1和ACO-2的人源化形式,以及它们的变体。
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公开(公告)号:US20130101602A1
公开(公告)日:2013-04-25
申请号:US13719536
申请日:2012-12-19
申请人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
发明人: Lars Anders Svensson , Soren Padkjaer , Birgitte Friedrichsen , Berit Olsen Krogh , Inger Lund Pedersen
IPC分类号: C07K16/24
CPC分类号: C07K16/249 , C07K16/464 , C07K2317/34
摘要: The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.
摘要翻译: 本发明提供可用于人类治疗应用的人源化抗人IFN-α单克隆抗体。 优选的抗体是鼠抗体ACO-1和ACO-2的人源化形式,以及它们的变体。
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