公开(公告)号：US08741848B2

公开(公告)日：2014-06-03

申请号：US12162505

申请日：2007-01-29

申请人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

发明人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

IPC分类号： A61K38/00

CPC分类号： A61K9/1647 ,  A61K9/0021 ,  A61K38/1808

摘要： The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.

摘要翻译： 本发明涉及一种药物组合物，其包含含有表皮生长因子（EGF）的聚合微球，其通过肠胃外途径施用于具有皮肤慢性缺血性溃疡性创伤的糖尿病患者的下肢。 与现有技术相比，本文所述的药物组合物是有用的，因为在治疗期间减少施用频率并且允许在相对于注射等量的非 - 非甾体抗炎药物的较短时间间隔内愈合溃疡性伤口， 封装的EGF。

公开(公告)号：US20090220608A1

公开(公告)日：2009-09-03

申请号：US12162505

申请日：2007-01-29

申请人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

发明人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

IPC分类号： A61K9/10 ,  A61K9/14 ,  A61K38/18

CPC分类号： A61K9/1647 ,  A61K9/0021 ,  A61K38/1808

摘要： The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.

摘要翻译： 本发明涉及一种药物组合物，其包含含有表皮生长因子（EGF）的聚合微球，其通过肠胃外途径施用于具有皮肤慢性缺血性溃疡性创伤的糖尿病患者的下肢。 与现有技术相比，本文所述的药物组合物是有用的，因为在治疗期间减少施用频率并且允许在相对于注射等量的非 - 非甾体抗炎药物的较短时间间隔内愈合溃疡性伤口， 封装的EGF。