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1.发明授权Pharmaceutical composition of microspheres for preventing diabetic foot amputation 有权用于预防糖尿病足部截肢的微球的药物组成公开(公告)号：US08741848B2
公开(公告)日：2014-06-03
申请号：US12162505
申请日：2007-01-29
申请人： Vivian Maria Sáez Martinez , Rolando Páez Meireles , Jorge Amador Berlanga Acosta , Blas Yamir Betancourt Rodriguez , José Ángel Ramón Hernández
发明人： Vivian Maria Sáez Martinez , Rolando Páez Meireles , Jorge Amador Berlanga Acosta , Blas Yamir Betancourt Rodriguez , José Ángel Ramón Hernández
IPC分类号： A61K38/00
CPC分类号： A61K9/1647 , A61K9/0021 , A61K38/1808
摘要： The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.
摘要翻译： 本发明涉及一种药物组合物，其包含含有表皮生长因子（EGF）的聚合微球，其通过肠胃外途径施用于具有皮肤慢性缺血性溃疡性创伤的糖尿病患者的下肢。 与现有技术相比，本文所述的药物组合物是有用的，因为在治疗期间减少施用频率并且允许在相对于注射等量的非 - 非甾体抗炎药物的较短时间间隔内愈合溃疡性伤口， 封装的EGF。
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2.发明申请PHARMACEUTICAL COMPOSITION OF MICROSPHERES FOR PREVENTING DIABETIC FOOT AMPUTATION 有权用于预防糖尿病足部放大的微生物药物组合物公开(公告)号：US20090220608A1
公开(公告)日：2009-09-03
申请号：US12162505
申请日：2007-01-29
申请人： Vivian Maria Sáez Martinez , Rolando Páez Meireles , Jorge Amador Berlanga Acosta , Blas Yamir Betancourt Rodriguez , José Ángel Ramón Hernández
发明人： Vivian Maria Sáez Martinez , Rolando Páez Meireles , Jorge Amador Berlanga Acosta , Blas Yamir Betancourt Rodriguez , José Ángel Ramón Hernández
CPC分类号： A61K9/1647 , A61K9/0021 , A61K38/1808
摘要： The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.
摘要翻译： 本发明涉及一种药物组合物，其包含含有表皮生长因子（EGF）的聚合微球，其通过肠胃外途径施用于具有皮肤慢性缺血性溃疡性创伤的糖尿病患者的下肢。 与现有技术相比，本文所述的药物组合物是有用的，因为在治疗期间减少施用频率并且允许在相对于注射等量的非 - 非甾体抗炎药物的较短时间间隔内愈合溃疡性伤口， 封装的EGF。
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3.发明申请Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof 有权肽生长激素促分泌素类似物及其制备方法公开(公告)号：US20100055118A1
公开(公告)日：2010-03-04
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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4.发明申请Combination of EGF/GHRP-6 for Neurogeneration of Central Nervous System Following Autoimmune Damage 审中-公开EGF / GHRP-6用于自身免疫损伤后中枢神经系统神经生成的组合公开(公告)号：US20100093616A1
公开(公告)日：2010-04-15
申请号：US11885330
申请日：2006-02-24
申请人： Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , Jorge Amador Berlanga Acosta , Freya de los Milagros Freyre Almeida , Danay Cibrian Vera , Eduardo Pentón Arias
发明人： Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , Jorge Amador Berlanga Acosta , Freya de los Milagros Freyre Almeida , Danay Cibrian Vera , Eduardo Pentón Arias
IPC分类号： A61K38/18
CPC分类号： A61K38/08 , A61K38/1808 , A61K38/25 , A61K2300/00
摘要： The present invention is directed to stimulate the neuroregeneration of the central nervous system due to autoimmune damage. In particular the pharmaceutical combination that comprise therapeutically effective concentrations of the Epidermal Growth Factor and the Growth Hormone Releasing Peptide-6, is administrated to a subject that suffers from symptoms of Multiple Sclerosis and Optic Neuromyelitis and corrects the demyelination caused by autoreactive cells in central nervous system.
摘要翻译： 本发明旨在刺激由于自身免疫损伤引起的中枢神经系统的神经再生。 特别地，包含治疗有效浓度的表皮生长因子和生长激素释放肽-6的药物组合被施用于患有多发性硬化症和视神经脊髓炎症状的受试者，并且校正由中枢神经中的自身反应性细胞引起的脱髓鞘 系统。
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5.发明授权公开(公告)号：US08367620B2
公开(公告)日：2013-02-05
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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6.发明申请USE OF A TOPICAL COMPOSITION CONTAINING EPIDERMAL GROWTH FACTOR (EGF) FOR DIABETIC FOOT AMPUTATION PREVENTION 审中-公开使用含有EPIDM生长因子（EGF）的局部组合物进行糖尿病防治公开(公告)号：US20090074850A1
公开(公告)日：2009-03-19
申请号：US12159159
申请日：2006-12-28
申请人： Elder Pupo Escalona , Rolando Paez Meireles , Jorge Amador Berlanga Acosta , Blas Yamir Betancourt Rodriquez
发明人： Elder Pupo Escalona , Rolando Paez Meireles , Jorge Amador Berlanga Acosta , Blas Yamir Betancourt Rodriquez
CPC分类号： A61K9/127 , A61K38/1808
摘要： The present invention is related to the use of topical formulations that contain epidermal growth factor encapsulated in or associated to deformable or conventional liposomes to be applied on the surface of and around chronic ischemic skin lesions. The formulations of the present invention, in contrast with the previous art, are useful because they provide a high bioavailability of EGF in the tissue deep below the lesions and for preventing diabetic foot amputation.
摘要翻译： 本发明涉及包含表皮生长因子的局部制剂的使用，所述表皮生长因子包封在可变形或常规脂质体中或与可应用于慢性缺血性皮肤损伤的周围的表面上相关联。 与先前技术相反，本发明的制剂是有用的，因为它们在深度在病变深处的组织中提供高生物利用度的EGF并且用于预防糖尿病足部截肢。
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7.发明授权Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy 有权使用表皮生长因子进行糖尿病神经病变外周神经的形态功能恢复公开(公告)号：US08642552B2
公开(公告)日：2014-02-04
申请号：US12443837
申请日：2007-10-01
申请人： Jose Ignacio Fernandez Montequin , Luis Saturnino Herrera Martinez , Jorge Amador Berlanga Acosta , Diana Garcia Del Barco Herrera , Danay Cibrian Vera , Gerardo Enrique Guillen Nieto , Raimundo Ubieta Gomez , Sonia Gonzalez Blanco , Vivian Maria Saez Martinez
发明人： Jose Ignacio Fernandez Montequin , Luis Saturnino Herrera Martinez , Jorge Amador Berlanga Acosta , Diana Garcia Del Barco Herrera , Danay Cibrian Vera , Gerardo Enrique Guillen Nieto , Raimundo Ubieta Gomez , Sonia Gonzalez Blanco , Vivian Maria Saez Martinez
IPC分类号： A61P25/02 , A61K38/18 , C07K14/485
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
摘要翻译： 本发明涉及人类药物和表皮生长因子（EGF）用于制备药物组合物的用途，所述药物组合物通过渗透到神经节和/或树干的周围而在疼痛的感觉运动神经病变中用于外周神经的形态功能恢复 以及缺血性神经炎的表现。 本发明还包括含有EGF的组合物，其可以与麻醉剂或止痛剂一起配制或包封在微球体中，以及其用于在疼痛敏感性运动型糖尿病性神经病变中的周围神经的形态功能恢复和缺血性神经炎的表现的用途。
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8.发明申请公开(公告)号：US20100136062A1
公开(公告)日：2010-06-03
申请号：US12443837
申请日：2007-10-01
申请人： Jose Ignacio Fernandez Montequin , Luis Saturnino Herrera Martinez , Jorge Amador Berlanga Acosta , Diana Garcia Del Barco Herrera , Danay Cibrian Vera , Gerardo Enrique Guillen Nieto , Raimundo Ubieta Gomez , Sonia Gonzalez Blanco , Vivian Maria Saez Martinez
发明人： Jose Ignacio Fernandez Montequin , Luis Saturnino Herrera Martinez , Jorge Amador Berlanga Acosta , Diana Garcia Del Barco Herrera , Danay Cibrian Vera , Gerardo Enrique Guillen Nieto , Raimundo Ubieta Gomez , Sonia Gonzalez Blanco , Vivian Maria Saez Martinez
IPC分类号： A61K38/18 , C07K14/485 , A61K9/00 , A61P25/02
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
摘要翻译： 本发明涉及人类药物和表皮生长因子（EGF）用于制备药物组合物的用途，所述药物组合物通过渗透到神经节和/或树干的周围而在疼痛的感觉运动神经病变中用于外周神经的形态功能恢复 以及缺血性神经炎的表现。 本发明还包括含有EGF的组合物，其可以与麻醉剂或止痛剂一起配制或包封在微球体中，以及其用于在疼痛敏感性运动型糖尿病性神经病变中的周围神经的形态功能恢复和缺血性神经炎的表现的用途。
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