公开(公告)号：US08741848B2

公开(公告)日：2014-06-03

申请号：US12162505

申请日：2007-01-29

申请人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

发明人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

IPC分类号： A61K38/00

CPC分类号： A61K9/1647 ,  A61K9/0021 ,  A61K38/1808

摘要： The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.

摘要翻译： 本发明涉及一种药物组合物，其包含含有表皮生长因子（EGF）的聚合微球，其通过肠胃外途径施用于具有皮肤慢性缺血性溃疡性创伤的糖尿病患者的下肢。 与现有技术相比，本文所述的药物组合物是有用的，因为在治疗期间减少施用频率并且允许在相对于注射等量的非 - 非甾体抗炎药物的较短时间间隔内愈合溃疡性伤口， 封装的EGF。

公开(公告)号：US08703893B2

公开(公告)日：2014-04-22

申请号：US12095335

申请日：2006-11-20

申请人： José Ángel Ramón Hernández ,  Fidel Raúl Castro Odio ,  Vivian-María Sáez Martinez ,  Rolando Páez Meircles ,  Eduardo Fernández Sánchez

发明人： José Ángel Ramón Hernández ,  Fidel Raúl Castro Odio ,  Vivian-María Sáez Martinez ,  Rolando Páez Meircles ,  Eduardo Fernández Sánchez

IPC分类号： A61K31/765 ,  C12N9/70

CPC分类号： A61K47/60

摘要： A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability.

摘要翻译： 具有四个分支的单甲氧基 - 聚乙二醇的聚合物树状聚合物样结构，其可以表示为：先前结构的羧基可以官能化用于制备药物感兴趣的缀合物。 这种树枝状大分子聚乙二醇与治疗性蛋白质的结合改善了其体外和体内稳定性。

公开(公告)号：US20090220608A1

公开(公告)日：2009-09-03

申请号：US12162505

申请日：2007-01-29

申请人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

发明人： Vivian Maria Sáez Martinez ,  Rolando Páez Meireles ,  Jorge Amador Berlanga Acosta ,  Blas Yamir Betancourt Rodriguez ,  José Ángel Ramón Hernández

IPC分类号： A61K9/10 ,  A61K9/14 ,  A61K38/18

CPC分类号： A61K9/1647 ,  A61K9/0021 ,  A61K38/1808

摘要： The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.

摘要翻译： 本发明涉及一种药物组合物，其包含含有表皮生长因子（EGF）的聚合微球，其通过肠胃外途径施用于具有皮肤慢性缺血性溃疡性创伤的糖尿病患者的下肢。 与现有技术相比，本文所述的药物组合物是有用的，因为在治疗期间减少施用频率并且允许在相对于注射等量的非 - 非甾体抗炎药物的较短时间间隔内愈合溃疡性伤口， 封装的EGF。