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公开(公告)号：US06352697B1
公开(公告)日：2002-03-05
申请号：US08809987
申请日：1999-02-22
IPC分类号： A61K4500
CPC分类号： A61K36/73 , Y10S514/885
摘要： Saponin preparations based on defined compositions of purified saponin fractions derived from the bark of Quillaja saponaria Molina are disclosed. The saponin preparations are useful in immunostimulating complex (iscom) matrices. The saponin preparations, and iscom matrices prepared using them, have particular activity as adjuvants.
摘要翻译： 公开了基于来自Quillaja saponaria Molina的树皮的纯化皂苷部分的定义的组合物的皂苷制剂。 皂苷制剂可用于免疫刺激复合物（iscom）基质。 使用它们制备的皂苷制剂和iscom基质具有作为佐剂的特定活性。
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公开(公告)号：US20100098490A1
公开(公告)日：2010-04-22
申请号：US12582170
申请日：2009-10-20
申请人： Lars-Olof Liberg , Bo Sundquist
发明人： Lars-Olof Liberg , Bo Sundquist
摘要： A marine structure comprising a supporting member that comprises a wall at least partially delimiting said supporting member such that an inner side of said wall is arranged to at least partially delimit an inner volume of said supporting member and an outer side of said wall is arranged to face the ambient environment of said supporting member. The marine structure further comprises a drain pipe adapted to guide fluid from said marine structure to a body of water at least partially surrounding said marine structure. At least a portion of said outer side of said wall partially delimits said drain pipe.
摘要翻译： 一种海洋结构，包括支撑构件，所述支撑构件包括壁，所述壁至少部分地限定所述支撑构件，使得所述壁的内侧布置成至少部分地限定所述支撑构件的内部容积，并且所述壁的外侧布置成 面对所述支撑构件的周围环境。 海洋结构还包括排水管，其适于将流体从所述海洋结构引导至至少部分地围绕所述海洋结构的水体。 所述壁的所述外侧的至少一部分部分地限定所述排水管。
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公开(公告)号：US08317428B2
公开(公告)日：2012-11-27
申请号：US12582170
申请日：2009-10-20
申请人： Lars-Olof Liberg , Bo Sundquist
发明人： Lars-Olof Liberg , Bo Sundquist
IPC分类号： B63B13/00
摘要： A marine structure comprising a supporting member that comprises a wall at least partially delimiting said supporting member such that an inner side of said wall is arranged to at least partially delimit an inner volume of said supporting member and an outer side of said wall is arranged to face the ambient environment of said supporting member. The marine structure further comprises a drain pipe adapted to guide fluid from said marine structure to a body of water at least partially surrounding said marine structure. At least a portion of said outer side of said wall partially delimits said drain pipe.
摘要翻译： 一种海洋结构，包括支撑构件，所述支撑构件包括壁，所述壁至少部分地限定所述支撑构件，使得所述壁的内侧布置成至少部分地限定所述支撑构件的内部容积，并且所述壁的外侧布置成 面对所述支撑构件的周围环境。 海洋结构还包括排水管，其适于将流体从所述海洋结构引导至至少部分地围绕所述海洋结构的水体。 所述壁的所述外侧的至少一部分部分地限定所述排水管。
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公开(公告)号：US5679354A
公开(公告)日：1997-10-21
申请号：US671816
申请日：1991-05-21
申请人： Bror Morein , Karin Lovgren , Kristian Dalsgaard , Jan Thurin , Bo Sundquist
发明人： Bror Morein , Karin Lovgren , Kristian Dalsgaard , Jan Thurin , Bo Sundquist
IPC分类号： A61K39/00 , A61K31/565 , A61K39/39 , A61K45/00 , A61P37/04 , C07H3/06 , C07H15/256 , C07J17/00 , C07J63/00 , A61K47/08
CPC分类号： C07H3/06 , A61K31/565 , A61K39/39 , C07H15/256 , A61K2039/55577
摘要： The invention claims an iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponim but no intentional antigenic determinants and optionally also adjuvants for use as an immunomodulating agent, medicines, vaccines, kits containing the matrix and new saponins, and a process for preparing the new saponins. The invention also concerns a process for preparing the matrix characterized in that at least one sterol is solubilized in a solvent or detergent, the saponin or saponins are added, the other adjuvants and lipids are optionally also added, whereafter the organic solvent or the detergent may be removed for example with dialysis, ultra filtration, gel filtration or electrophoresis. The sterol and saponin might also be solubilized in the lipids and/or adjuvants.
摘要翻译： PCT No.PCT / SE89 / 00528 Sec。 371日期1991年5月21日 102（e）日期1991年5月21日PCT提交1989年9月28日PCT公布。 出版物WO90 / 03184 1990年04月5日发明内容本发明要求一种iscom基质，其不是包含至少一种脂质和至少一种皂苷但不含有意的抗原决定簇的脂质囊泡，并且任选地还包含用作免疫调节剂的辅助剂，药物，疫苗，含有 基质和新皂苷，以及制备新皂苷的方法。 本发明还涉及一种制备基质的方法，其特征在于至少一种固醇溶于溶剂或洗涤剂中，加入皂角苷或皂苷，任选地还加入其它佐剂和脂质，此后有机溶剂或洗涤剂可以 例如通过透析，超滤，凝胶过滤或电泳除去。 甾醇和皂苷也可以溶解在脂质和/或佐剂中。
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