-
公开(公告)号：US06352697B1
公开(公告)日：2002-03-05
申请号：US08809987
申请日：1999-02-22
Applicant: John Cooper Cox , Alan Robert Coulter , Bror Morein , Karin Lovgren-Bengtsson , Bo Sundquist
Inventor： John Cooper Cox , Alan Robert Coulter , Bror Morein , Karin Lovgren-Bengtsson , Bo Sundquist
IPC: A61K4500
CPC classification number: A61K36/73 , Y10S514/885
Abstract: Saponin preparations based on defined compositions of purified saponin fractions derived from the bark of Quillaja saponaria Molina are disclosed. The saponin preparations are useful in immunostimulating complex (iscom) matrices. The saponin preparations, and iscom matrices prepared using them, have particular activity as adjuvants.
Abstract translation: 公开了基于来自Quillaja saponaria Molina的树皮的纯化皂苷部分的定义的组合物的皂苷制剂。 皂苷制剂可用于免疫刺激复合物（iscom）基质。 使用它们制备的皂苷制剂和iscom基质具有作为佐剂的特定活性。
-
公开(公告)号：US07776343B1
公开(公告)日：2010-08-17
申请号：US09506011
申请日：2000-02-17
Applicant: John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
Inventor： John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
IPC: A61K47/00
CPC classification number: A61K39/39 , A61K2039/55511 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577 , A61K2039/57
Abstract: The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen. The complexes of the present invention are useful, inter alia, as therapeutic and/or prophylactic agents for facilitating the induction of a cytotoxic T-lymphocyte response to an antigen.
-
公开(公告)号：US06726912B1
公开(公告)日：2004-04-27
申请号：US10011749
申请日：2001-12-11
Applicant: Elizabeth Ann Webb , Mary Brigid Margetts , John Cooper Cox , Ian Frazer , Nigel Alan John McMillan , Mark Philip Williams , Margaret Bridget Holland Moloney , Stirling John Edwards
Inventor： Elizabeth Ann Webb , Mary Brigid Margetts , John Cooper Cox , Ian Frazer , Nigel Alan John McMillan , Mark Philip Williams , Margaret Bridget Holland Moloney , Stirling John Edwards
IPC: A61K3912
CPC classification number: C07K14/005 , A61K39/00 , C12N2710/20022 , Y02A50/472
Abstract: A papillomavirus polyprotein construct comprises at least two amino acid sequences fused directly or indirectly together, each of the sequences being the sequence of an early ORF protein of papillomavirus or an immunogenic variant or fragment thereof, and at least one of said sequences being other than the E6 or E7 protein sequence or an immunogenic variant or fragment thereof. Nucleic acid molecules encoding the polyprotein construct, prophylactic or therapeutic compositions comprising the polyprotein construct or the nucleic acid molecule, and methods for eliciting an immune response against papillomavirus in a host animal are also provided.
Abstract translation: 乳头瘤病毒多蛋白构建体包含直接或间接融合在一起的至少两个氨基酸序列，每个序列是乳头瘤病毒的早期ORF蛋白或其免疫原性变体或片段的序列，并且所述序列中的至少一个不同于 E6或E7蛋白质序列或其免疫原性变体或片段。 还提供了编码聚蛋白构建体的核酸分子，包含多蛋白构建体或核酸分子的预防或治疗组合物，以及用于在宿主动物中引发针对乳头瘤病毒的免疫应答的方法。
-
公开(公告)号：US06306397B1
公开(公告)日：2001-10-23
申请号：US09359382
申请日：1999-07-23
Applicant: Stirling John Edwards , John Cooper Cox , Elizabeth Ann Webb , Ian Frazer
Inventor： Stirling John Edwards , John Cooper Cox , Elizabeth Ann Webb , Ian Frazer
IPC: A61K3900
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2710/20022
Abstract: Variants of human papilloma virus (HPV) E6 and E7 proteins able to elicit a humoral and/or cellular immune response against HPV in a host animal but not being cell-transforming in the host animal are disclosed, and are useful in treatment or prevention of diseases or conditions involving HPV.
Abstract translation: 公开了能够在宿主动物中引起针对HPV的体液和/或细胞免疫应答但不在宿主动物中进行细胞转化的人乳头状瘤病毒（HPV）E6和E7蛋白的变体，并且可用于治疗或预防 涉及HPV的疾病或病症。
-
5.发明授权
公开(公告)号：US5902565A
公开(公告)日：1999-05-11
申请号：US481403
申请日：1995-07-10
Applicant: John Cooper Cox , Robert Edward Sparks , Irwin Clay Jacobs , Norbert Simon Mason
Inventor： John Cooper Cox , Robert Edward Sparks , Irwin Clay Jacobs , Norbert Simon Mason
CPC classification number: A61K9/1647 , A61K39/39 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , Y10S977/917
Abstract: Vaccine preparations in stable particulate form are disclosed. An immediate-release preparation comprises an immunogen adsorbed to an aluminum adjuvant. A controlled- or delayed-release preparation comprises microspherical particles comprising a continuous matrix of biodegradable polymer containing discrete, immunogen-containing regions.
Abstract translation: PCT No.PCT / AU93 / 00677 Sec。 371日期1995年7月10日 102（e）日期1995年7月10日PCT提交1993年12月24日PCT公布。 出版物WO94 / 15636 日期：1994年7月21日公开了稳定颗粒形式的疫苗制剂。 立即释放制剂包含吸附在铝佐剂上的免疫原。 受控或延迟释放制剂包含微球颗粒，其包含含分散的含免疫原区域的可生物降解的聚合物的连续基质。
-
Patent Agency Ranking
公开(公告)号：US08173141B2
公开(公告)日：2012-05-08
申请号：US12458116
申请日：2009-07-01
Applicant: John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
Inventor： John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
IPC: A61K47/00
CPC classification number: A61K39/39 , A61K2039/55511 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577 , A61K2039/57
Abstract: The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen. The complexes of the present invention are useful, inter alia, as therapeutic and/or prophylactic agents for facilitating the induction of a cytotoxic T-lymphocyte response to an antigen.
Abstract translation: 本发明一般涉及包含带电荷的有机载体和带电荷的抗原的免疫原性复合物，更具体地说，涉及带负电荷的有机载体和带正电荷的抗原。 本发明的复合物尤其可用作促进诱导对抗原的细胞毒性T淋巴细胞应答的治疗和/或预防剂。
-
公开(公告)号：US06365160B1
公开(公告)日：2002-04-02
申请号：US09000094
申请日：1998-04-21
Applicant: Elizabeth Ann Webb , Mary Brigid Margetts , John Cooper Cox , Ian Frazer , Nigel Alan John McMillan , Mark Philip Williams , Margaret Bridget Holland Moloney , Stirling John Edwards
Inventor： Elizabeth Ann Webb , Mary Brigid Margetts , John Cooper Cox , Ian Frazer , Nigel Alan John McMillan , Mark Philip Williams , Margaret Bridget Holland Moloney , Stirling John Edwards
IPC: A61K3900
CPC classification number: C07K14/005 , A61K39/00 , C12N2710/20022 , Y02A50/472
Abstract: Peptides, antibodies and recombinant expression systems or cells that contain and express a DNA insert of HPV encoding a region of a papilloma induced or a papilloma protein, such as E6 or E7, are produced. Compositions containing these peptides, antibodies and/or recombinant cells are utilized as immunogenic compositions and in methods for inhibiting and treating HPV infection and tumor initiation and progression. Specific peptides and recombinant cells, such as vaccinia virus and tumor cells, that express epitopic regions of the HPV16 E6 or E7 nucleoprotein are particularly described.
Abstract translation: 产生含有和表达编码乳头状瘤区域的HPV编码HPV插入片段或例如E6或E7的肽，抗体和重组表达系统或细胞。 含有这些肽，抗体和/或重组细胞的组合物用作免疫原性组合物和用于抑制和治疗HPV感染和肿瘤起始和进展的方法。 具体描述了表达HPV16E6或E7核蛋白的表位区域的特异性肽和重组细胞，例如痘苗病毒和肿瘤细胞。
-
公开(公告)号：US6004557A
公开(公告)日：1999-12-21
申请号：US860165
申请日：1997-09-22
Applicant: Stirling John Edwards , John Cooper Cox , Elizabeth Ann Webb , Ian Frazer
Inventor： Stirling John Edwards , John Cooper Cox , Elizabeth Ann Webb , Ian Frazer
IPC: C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/39 , A61P31/12 , C07K14/025 , C07K19/00 , C12N1/21 , C12N15/37 , C12N15/62 , C12P21/02 , C12R1/19 , C12N7/00
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2710/20022
Abstract: Variants of human papilloma virus (HPV) E6 and E7 able to elicit a humoral or cellular immune response against HPV in a host animal but not being cell-transforming in the host animal are disclosed, and are useful in treatment or prevention of diseases or conditions involving HPV.
Abstract translation: PCT No.PCT / AU95 / 00868 Sec。 371日期：1997年9月22日 102（e）1997年9月22日PCT 1995年12月20日PCT PCT。 公开号WO96 / 19496 日期1997年6月27日公开了能够在宿主动物中引起针对HPV的体液或细胞免疫应答的人乳头状瘤病毒（HPV）E6和E7的变体，但不在宿主动物中进行细胞转化，并且可用于治疗或 预防涉及HPV的疾病或病症。
-
公开(公告)号：US20100010193A1
公开(公告)日：2010-01-14
申请号：US12458116
申请日：2009-07-01
Applicant: John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
Inventor： John Cooper Cox , Debbie Pauline Drane , Andreas Suhrbier
IPC: C07K1/00
CPC classification number: A61K39/39 , A61K2039/55511 , A61K2039/55561 , A61K2039/55572 , A61K2039/55577 , A61K2039/57
Abstract: The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen. The complexes of the present invention are useful, inter alia, as therapeutic and/or prophylactic agents for facilitating the induction of a cytotoxic T-lymphocyte response to an antigen.
Abstract translation: 本发明一般涉及包含带电荷的有机载体和带电荷的抗原的免疫原性复合物，更具体地说，涉及带负电荷的有机载体和带正电荷的抗原。 本发明的复合物尤其可用作促进诱导对抗原的细胞毒性T淋巴细胞应答的治疗和/或预防剂。
-
公开(公告)号：US06814981B1
公开(公告)日：2004-11-09
申请号：US09445749
申请日：2000-02-10
Applicant: John Cooper Cox , Bengt John Lennart Ronnberg , Sigrid Elisabet Sjolander
IPC: A61K951
CPC classification number: A61K39/145 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K45/06 , A61K2039/55511 , A61K2039/55577
Abstract: An immunostimulating complex comprising one or more ganglosides, illustrated by the ganglosides GM2, GD2, GD3 or GT3, is useful as a prophylactic or therapeutic agent in the treatment of tumors, inter alia, especially melanomas.
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.022 seconds)
