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1.
公开(公告)号:US09186421B2
公开(公告)日:2015-11-17
申请号:US13637125
申请日:2010-03-26
申请人: Yanrong Lu , Jingqiu Cheng , Shaoping Deng , Younan Chen , Bole Tian , Gang Mai , Yan Ren , Li Wang , Hongxia Li , Lingling Wei , Xi Jin , Chaofeng Qiao , Wensheng Zhang , Sirong He , Li Zeng
发明人: Yanrong Lu , Jingqiu Cheng , Shaoping Deng , Younan Chen , Bole Tian , Gang Mai , Yan Ren , Li Wang , Hongxia Li , Lingling Wei , Xi Jin , Chaofeng Qiao , Wensheng Zhang , Sirong He , Li Zeng
IPC分类号: A01K67/00 , A61K49/00 , A01K67/027
CPC分类号: A61K49/0008 , A01K67/027 , A01K2207/20 , A01K2227/106 , A01K2267/0362
摘要: Use of low dose streptozocin in the preparation of an animal model for screening drugs for treatment of antoimmune type 1 diabetes is disclosed, in which streptozocin is administrated intravenously at a dose of 15-30 mg/kg per time for 5 days and administrated again on the 7th day and 14th day after last time of offering drug. A method for preparing rhesus monkey model of autoimmune type 1 diabetes and autoimmune type 1 diabetes animal model obtained are also disclosed.
摘要翻译: 公开了使用低剂量链脲佐菌素制备动物模型以筛选用于治疗无免疫性1型糖尿病的药物,其中以15-30mg / kg的剂量静脉内施用链脲佐菌素5天,并再次施用 上次提供药物后的第七天和第十四天。 还公开了获得的自身免疫性1型糖尿病和自身免疫性1型糖尿病动物模型的恒河猴模型的制备方法。
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2.
公开(公告)号:US20130149733A1
公开(公告)日:2013-06-13
申请号:US13637125
申请日:2010-03-26
申请人: Yanrong Lu , Jingqiu Cheng , Shaoping Deng , Younan Chen , Bole Tian , Gang Mai , Yan Ren , Li Wang , Hongxia Li , Lingling Wei , Xi Jin , Chaofeng Qiao , Wensheng Zhang , Sirong He , Li Zeng
发明人: Yanrong Lu , Jingqiu Cheng , Shaoping Deng , Younan Chen , Bole Tian , Gang Mai , Yan Ren , Li Wang , Hongxia Li , Lingling Wei , Xi Jin , Chaofeng Qiao , Wensheng Zhang , Sirong He , Li Zeng
IPC分类号: A01K67/027 , C12Q1/02
CPC分类号: A61K49/0008 , A01K67/027 , A01K2207/20 , A01K2227/106 , A01K2267/0362
摘要: Use of low dose streptozocin in the preparation of an animal model for screening drugs for treatment of antoimmune type 1 diabetes is disclosed, in which streptozocin is administrated intravenously at a dose of 15-30 mg/kg per time for 5 days and administrated again on the 7th day and 14th day after last time of offering drug. A method for preparing rhesus monkey model of autoimmune type 1 diabetes and autoimmune type 1 diabetes animal model obtained are also disclosed.
摘要翻译: 公开了使用低剂量链脲佐菌素制备动物模型以筛选用于治疗无免疫性1型糖尿病的药物,其中以15-30mg / kg的剂量静脉内施用链脲佐菌素5天,并再次施用 上次提供药物后的第七天和第十四天。 还公开了获得的自身免疫性1型糖尿病和自身免疫性1型糖尿病动物模型的恒河猴模型的制备方法。
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