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    Hydroxy Acid Ester Compound of Substituted Phenol, Preparation Method and Medical Use Thereof
    1.
    发明申请
    Hydroxy Acid Ester Compound of Substituted Phenol, Preparation Method and Medical Use Thereof 有权
    取代苯酚的羟基酸酯化合物，其制备方法和医疗用途

    公开(公告)号：US20130079405A1

    公开(公告)日：2013-03-28

    申请号：US13702188

    申请日：2010-10-13

    申请人： Wensheng Zhang ,  Jun Yang ,  Jin Liu

    发明人： Wensheng Zhang ,  Jun Yang ,  Jin Liu

    IPC分类号： C07C59/48 ,  C07C67/32

    CPC分类号： C07C59/48 ,  C07C67/31 ,  C07C67/32 ,  C07C69/675

    摘要： Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y═C14 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.

    摘要翻译： 提供取代苯基酯的羟基酸化合物，其制备方法和医疗用途。 标题化合物如式（I）所示，Y = C14直链碳链。 该化合物可在体内酶的作用下快速释放2,6-二异丙基苯酚，其具有镇静，催眠和/或麻醉作用。 通过保护式（I）化合物中2,6-二异丙基苯酚的羟基，2,6-二异丙基苯酚的首过代谢活性降低，合成化合物可用于镇静，催眠和/或 麻醉。

    SOLVENT EXTRACTION PROCESS FOR SEPARATING COBALT FROM NICKEL IN AQUEOUS SOLUTION
    2.
    发明申请
    SOLVENT EXTRACTION PROCESS FOR SEPARATING COBALT FROM NICKEL IN AQUEOUS SOLUTION 有权
    用于从镍水溶液中分离钴的溶剂萃取工艺

    公开(公告)号：US20110283838A1

    公开(公告)日：2011-11-24

    申请号：US12784037

    申请日：2010-05-20

    申请人： David Llewellyn JONES ,  Tannice Marie McCOY ,  Keith Edward MAYHEW ,  Chu Yong CHENG ,  Keith Raymond BARNARD ,  Wensheng ZHANG

    发明人： David Llewellyn JONES ,  Tannice Marie McCOY ,  Keith Edward MAYHEW ,  Chu Yong CHENG ,  Keith Raymond BARNARD ,  Wensheng ZHANG

    IPC分类号： C22B23/06 ,  C22B23/00

    CPC分类号： C22B23/0484 ,  C22B3/0005 ,  C22B3/20 ,  C22B3/42 ,  C22B3/44 ,  C22B23/0476 ,  Y02P10/234

    摘要： A process for separating Co from Ni in an aqueous solution comprises subjecting the solution to extraction and using kinetic differences between Ni and Co in the extraction for achieving at least a partial separation of Co from Ni. This is effected by controlling the duration of the extraction so that a major portion of Co and a minor portion of Ni is extracted from the solution to produce a loaded extractant, enriched in Co and depleted in Ni compared to the feed solution, and a Co-depleted raffinate containing Ni. In a further embodiment, the invention utilizes kinetic differences between Ni and Co during striping for effecting separation of Ni and Co. The loaded extractant can be subjected to a bulk stripping or a selective stripping operation to obtain Co and Ni solutions from which Ni and Co can be recovered. The process may be incorporated in a hydrometallurgical process for the extraction of Ni and/or Co from an ore or concentrate containing Ni and Co.

    摘要翻译： 在水溶液中从Co中分离Co的方法包括在提取中使溶液进行萃取和使用Ni和Co之间的动力学差异，以实现Co与Ni的至少部分分离。 这是通过控制提取的持续时间来实现的，从而从溶液中提取出大部分的Co和少部分的Ni，从而产生负载的萃取剂，其与进料溶液相比富含Co并且耗尽Ni，而Co 分离的含有Ni的残液。 在另一个实施方案中，本发明利用Ni和Co之间的动力学差异进行剥离以实现Ni和Co的分离。负载的萃取剂可以进行体积汽提或选择性剥离操作以获得Co和Ni溶液，Ni和Co 可以恢复。 该方法可以结合在湿法冶金方法中，用于从含有Ni和Co的矿石或浓缩物中提取Ni和/或Co

    Phosphate ester compound of hydroxy acid substituted phenol ester, preparation method and medical use thereof
    3.
    发明授权
    Phosphate ester compound of hydroxy acid substituted phenol ester, preparation method and medical use thereof 有权
    羟基酸取代苯酚酯的磷酸酯化合物，其制备方法和医疗用途

    公开(公告)号：US09243009B2

    公开(公告)日：2016-01-26

    申请号：US13702204

    申请日：2010-10-13

    申请人： Wensheng Zhang ,  Jun Yang ,  Jin Liu

    发明人： Wensheng Zhang ,  Jun Yang ,  Jin Liu

    IPC分类号： C07F9/09

    CPC分类号： C07F9/09 ,  C07F9/091

    摘要： Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y═C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.

    摘要翻译： 提供羟基酸取代苯基酯的磷酸酯化合物，其制备方法和医疗用途。 标题化合物如式（I）所示，其中Y = C1-4直碳链，M1和/或M2 = H，碱金属离子，质子化胺或质子化氨基酸。 该化合物在其水溶液中具有良好的水溶性和高稳定性，并且可以在体内酶的作用下快速释放2,6-二异丙基苯酚，其具有镇静，催眠和/或麻醉的作用。 通过保护式（I）化合物中2,6-二异丙基苯酚的羟基，2,6-二异丙基苯酚的首过代谢活性降低，合成化合物可用于镇静，催眠和/或麻醉。

    Solvent extraction process for separating cobalt from nickel in aqueous solution
    5.
    发明授权
    Solvent extraction process for separating cobalt from nickel in aqueous solution 有权
    在水溶液中从钴中分离钴的溶剂萃取方法

    公开(公告)号：US08979976B2

    公开(公告)日：2015-03-17

    申请号：US12784037

    申请日：2010-05-20

    申请人： David Llewellyn Jones ,  Tannice Marie McCoy ,  Keith Edward Mayhew ,  Chu Yong Cheng ,  Keith Raymond Barnard ,  Wensheng Zhang

    发明人： David Llewellyn Jones ,  Tannice Marie McCoy ,  Keith Edward Mayhew ,  Chu Yong Cheng ,  Keith Raymond Barnard ,  Wensheng Zhang

    IPC分类号： C22B23/00 ,  C22B3/42 ,  C22B3/00

    CPC分类号： C22B23/0484 ,  C22B3/0005 ,  C22B3/20 ,  C22B3/42 ,  C22B3/44 ,  C22B23/0476 ,  Y02P10/234

    摘要： A process for separating Co from Ni in an aqueous solution comprises subjecting the solution to extraction and using kinetic differences between Ni and Co in the extraction for achieving at least a partial separation of Co from Ni. This is effected by controlling the duration of the extraction so that a major portion of Co and a minor portion of Ni is extracted from the solution to produce a loaded extractant, enriched in Co and depleted in Ni compared to the feed solution, and a Co-depleted raffinate containing Ni. In a further embodiment, the invention utilizes kinetic differences between Ni and Co during striping for effecting separation of Ni and Co. The loaded extractant can be subjected to a bulk stripping or a selective stripping operation to obtain Co and Ni solutions from which Ni and Co can be recovered. The process may be incorporated in a hydrometallurgical process for the extraction of Ni and/or Co from an ore or concentrate containing Ni and Co.

    摘要翻译： 在水溶液中从Co中分离Co的方法包括在提取中使溶液进行萃取和使用Ni和Co之间的动力学差异，以实现Co与Ni的至少部分分离。 这是通过控制提取的持续时间来实现的，从而从溶液中提取出大部分的Co和少部分的Ni，从而产生负载的萃取剂，其与进料溶液相比富含Co并且耗尽Ni，而Co 分离的含有Ni的残液。 在另一个实施方案中，本发明利用Ni和Co之间的动力学差异进行剥离以实现Ni和Co的分离。负载的萃取剂可以进行体积汽提或选择性剥离操作以获得Co和Ni溶液，其中Ni和Co 可以恢复。 该方法可以结合在湿法冶金方法中，用于从含有Ni和Co的矿石或浓缩物中提取Ni和/或Co

    Laser alignment device with a movable mirror, laser-target alignment sensor with movable mirrors and laser alignment method
    7.
    发明授权
    Laser alignment device with a movable mirror, laser-target alignment sensor with movable mirrors and laser alignment method 有权
    具有可移动镜的激光对准装置，具有可动反射镜的激光对准传感器和激光对准方法

    公开(公告)号：US09360650B2

    公开(公告)日：2016-06-07

    申请号：US13520156

    申请日：2011-04-28

    申请人： Baolin Wu ,  Wensheng Zhang ,  Yali Shi ,  Yinxing Hao ,  Haipeng Li ,  Qiulei Dong ,  Haoxing Wang ,  Zhengtao Zhang

    发明人： Baolin Wu ,  Wensheng Zhang ,  Yali Shi ,  Yinxing Hao ,  Haipeng Li ,  Qiulei Dong ,  Haoxing Wang ,  Zhengtao Zhang

    IPC分类号： G01B11/14 ,  H04N7/18 ,  G02B7/00 ,  G02B26/08

    CPC分类号： G02B7/005 ,  G02B26/0816

    摘要： A laser alignment device with at least one movable mirror, a laser-target alignment sensor with movable mirrors and a laser alignment method are disclosed. The laser alignment device with the movable mirror comprises an image acquisition means for collecting incident lasers, a moveable mirror for reflecting the lasers to the image acquisition means and is operable to move linearly with respect to the image acquisition means, and a lens for forming an image of a target in the image acquisition means. The present disclosure achieves linear motion of the movable mirror with high accuracy in a small range, which in turn achieves fast and accurate alignment of the laser. It solves the problem of laser spots overlapping, reduces alignment time and improves shooting accuracy.

    摘要翻译： 公开了一种具有至少一个可移动反射镜的激光对准装置，具有可移动反射镜的激光对准传感器和激光对准方法。 具有可移动反射镜的激光对准装置包括用于收集入射激光的图像获取装置，用于将激光反射到图像获取装置的可移动反射镜，并且可操作以相对于图像获取装置线性地移动，以及用于形成 图像获取装置中的目标的图像。 本发明可以在小范围内实现高精度的可移动反射镜的线性运动，从而实现激光器的快速和准确的对准。 解决了激光点重叠的问题，缩短了对准时间，提高了拍摄精度。

    Hydroxy acid ester compound of substituted phenol, preparation method and medical use thereof
    8.
    发明授权
    Hydroxy acid ester compound of substituted phenol, preparation method and medical use thereof 有权
    取代苯酚的羟基酸酯化合物，其制备方法和医疗用途

    公开(公告)号：US09272978B2

    公开(公告)日：2016-03-01

    申请号：US13702188

    申请日：2010-10-13

    申请人： Wensheng Zhang ,  Jun Yang ,  Jin Liu

    发明人： Wensheng Zhang ,  Jun Yang ,  Jin Liu

    IPC分类号： C07C67/32 ,  C07C67/31 ,  C07C69/675 ,  C07C59/48

    CPC分类号： C07C59/48 ,  C07C67/31 ,  C07C67/32 ,  C07C69/675

    摘要： Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y═C1-4 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.

    摘要翻译： 提供取代苯基酯的羟基酸化合物，其制备方法和医疗用途。 标题化合物如式（I）所示，Y = C1-4直碳链。 该化合物可在体内酶的作用下快速释放2,6-二异丙基苯酚，其具有镇静，催眠和/或麻醉作用。 通过保护式（I）化合物中2,6-二异丙基苯酚的羟基，2,6-二异丙基苯酚的首过代谢活性降低，合成化合物可用于镇静，催眠和/或 麻醉。