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公开(公告)号：US07887800B2
公开(公告)日：2011-02-15
申请号：US12331104
申请日：2008-12-09
IPC分类号： A61K39/395 , C07K14/475
CPC分类号： A61K38/484 , A61K2039/505 , C07K16/22 , C12Q1/37 , G01N2333/475 , G01N2333/71 , G01N2333/96433 , G01N2500/02 , G01N2500/04
摘要： Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a pharmaceutical compositions comprising plasmin. Also disclosed are methods of screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-CD, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.
摘要翻译： 用纤溶酶激活内皮生长因子VEGF-C或VEGF-D的方法和治疗方法包括施用包含纤溶酶的药物组合物。 还公开了通过纤溶酶筛选生长因子活化抑制剂的方法和通过阻断纤溶酶的VEGF-C / D活化激活的方法。 进一步披露的是筛选其它激活VEGF-CD的蛋白酶的方法以及用于这种激活抑制剂的方法。 本发明还包括纤溶酶活性抑制剂和用所述抑制剂治疗有需要的患者的方法。
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2.发明申请METHODS AND COMPOSITIONS FOR ACTIVATING OR INHIBITING VEGF-D AND VEGF-C 失效用于激活或抑制VEGF-D和VEGF-C的方法和组合物公开(公告)号：US20090169551A1
公开(公告)日：2009-07-02
申请号：US12331104
申请日：2008-12-09
申请人： Bradley McColl , Megan E. Baldwin , Steven Stacker , Marc Achen
发明人： Bradley McColl , Megan E. Baldwin , Steven Stacker , Marc Achen
IPC分类号： A61K39/395 , A61P19/00 , A61P21/00
CPC分类号： A61K38/484 , A61K2039/505 , C07K16/22 , C12Q1/37 , G01N2333/475 , G01N2333/71 , G01N2333/96433 , G01N2500/02 , G01N2500/04
摘要： Methods for Activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a pharmaceutical compositions comprising plasmin. Also disclosed are methods of screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-CD, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.
摘要翻译： 用纤溶酶激活内皮生长因子VEGF-C或VEGF-D的方法和治疗方法包括施用包含纤溶酶的药物组合物。 还公开了通过纤溶酶筛选生长因子活化抑制剂的方法和通过阻断纤溶酶的VEGF-C / D活化激活的方法。 进一步披露的是筛选其它激活VEGF-CD的蛋白酶的方法以及用于这种激活抑制剂的方法。 本发明还包括纤溶酶活性抑制剂和用所述抑制剂治疗有需要的患者的方法。
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公开(公告)号：US20070224194A1
公开(公告)日：2007-09-27
申请号：US11566195
申请日：2006-12-01
申请人： Bradley McColl , Steven Stacker , Marc Achen , Karri Paavonen
发明人： Bradley McColl , Steven Stacker , Marc Achen , Karri Paavonen
IPC分类号： A61K31/7052 , A61K39/395
CPC分类号： C07K14/4703 , C07K5/1027 , C12N15/113
摘要： Proprotein convertase inhibitor has been found to block proteolytic processing and activation of VEGF-C and VEGF-D and inhibit angiogenesis and/or lymphangiogenesis. Method and composition are disclosed for inhibiting angiogenesis and/or lymphangiogenesis, and for treating conditions associated with excessive angiogenesis, such as tumors and/or retinopathies, as well as conditions associated with lymphangiogenesis, such as the metastatic spread of malignancies, macular degeneration, inflammatory mediated diseases, rheumatoid arthritis, diabetic retinopathy and psoriasis in a patient. The inventive method and composition utilize proprotein convertase antagonist selected from the group consisting of an anti-proprotein convertase antibody, an antisense nucleic acid molecule against a polynucleotide coding for a proprotein convertase, and an siRNA for inhibiting proprotein convertase expression, as well as proprotein convertase inhibitors.
摘要翻译： 已经发现前蛋白转化酶抑制剂阻断VEGF-C和VEGF-D的蛋白水解加工和活化并抑制血管生成和/或淋巴管生成。 公开了用于抑制血管发生和/或淋巴管生成的方法和组合，以及用于治疗与过度血管发生相关的病症，例如肿瘤和/或视网膜病变，以及与淋巴管生成相关的病症，例如恶性肿瘤的转移性扩散，黄斑变性，炎性 介导的疾病，类风湿性关节炎，糖尿病性视网膜病变和银屑病。 本发明的方法和组合物使用选自抗前体蛋白转化酶抗体，针对编码前蛋白转化酶的多核苷酸的反义核酸分子和用于抑制前蛋白转化酶表达的siRNA以及前蛋白转化酶 抑制剂。
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4.发明申请Methods and compositions for activating or inhibiting vegf-d and vegf-c 失效激活或抑制vegf-d和vegf-c的方法和组合物公开(公告)号：US20050282228A1
公开(公告)日：2005-12-22
申请号：US10522232
申请日：2003-07-21
申请人： Bradley Mccoll , Megan Baldwin , Steven Stacker , Narc Achen
发明人： Bradley Mccoll , Megan Baldwin , Steven Stacker , Narc Achen
CPC分类号： A61K38/484 , A61K2039/505 , C07K16/22 , C12Q1/37 , G01N2333/475 , G01N2333/71 , G01N2333/96433 , G01N2500/02 , G01N2500/04
摘要： Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a phamarceutical compositions comprising plasmin. Also disclosed are methods for screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-C/D, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.
摘要翻译： 用纤溶酶激活内皮生长因子VEGF-C或VEGF-D的方法和治疗方法包括施用包含纤溶酶的络合物组合物。 还公开了用于筛选纤溶酶激活生长因子抑制剂的方法，以及通过阻断纤溶酶的VEGF-C / D活化激活的方法。 进一步公开的是筛选其它激活VEGF-C / D的蛋白酶的方法，以及用于这种活化抑制剂的方法。 本发明还包括纤溶酶活性抑制剂和用所述抑制剂治疗有需要的患者的方法。
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公开(公告)号：US07479270B2
公开(公告)日：2009-01-20
申请号：US10522232
申请日：2003-07-21
申请人： Bradley McColl , Megan E. Baldwin , Steven Stacker , Marc Achen
发明人： Bradley McColl , Megan E. Baldwin , Steven Stacker , Marc Achen
IPC分类号： A61K38/43 , A61K38/48 , C07K14/435
CPC分类号： A61K38/484 , A61K2039/505 , C07K16/22 , C12Q1/37 , G01N2333/475 , G01N2333/71 , G01N2333/96433 , G01N2500/02 , G01N2500/04
摘要： Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a phamarceutical compositions comprising plasmin. Also disclosed are methods for screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-C/D, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.
摘要翻译： 用纤溶酶激活内皮生长因子VEGF-C或VEGF-D的方法和治疗方法包括施用包含纤溶酶的络合物组合物。 还公开了用于筛选纤溶酶激活生长因子抑制剂的方法，以及通过阻断纤溶酶的VEGF-C / D活化激活的方法。 进一步公开的是筛选其它激活VEGF-C / D的蛋白酶的方法，以及用于这种活化抑制剂的方法。 本发明还包括纤溶酶活性抑制剂和用所述抑制剂治疗有需要的患者的方法。
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公开(公告)号：US20050272664A1
公开(公告)日：2005-12-08
申请号：US11133415
申请日：2005-05-20
申请人： Bradley McColl , Steven Stacker , Marc Achen
发明人： Bradley McColl , Steven Stacker , Marc Achen
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/48 , A61K38/55 , A61K38/57 , C07K5/10 , C07K14/47
CPC分类号： A61K38/57 , A61K38/00 , A61K38/482 , C07K5/1027 , C07K14/4703 , C12Y304/21075
摘要： Proprotein convertase inhibitor has been found to block proteolytic processing and activation of VEGF-C and VEGF-D and inhibit angiogenesis and/or lymphangiogenesis. Method and composition are disclosed for inhibiting angiogenesis and/or lymphangiogenesis, and for treating conditions associated with excessive angiogenesis, such as tumors and/or retinopathies, as well as conditions associated with lymphangiogenesis, such as the metastatic spread of malignancies, macular degeneration, inflammatory mediated diseases, rheumatoid arthritis, diabetic retinopathy and psoriasis in a patient. The inventive method and composition utilize proprotein convertase antagonist selected from the group consisting of an anti-proprotein convertase antibody, an antisense nucleic acid molecule against a polynucleotide coding for a proprotein convertase, and an siRNA for inhibiting proprotein convertase expression, as well as proprotein convertase inhibitors.
摘要翻译： 已经发现前蛋白转化酶抑制剂阻断VEGF-C和VEGF-D的蛋白水解加工和活化并抑制血管生成和/或淋巴管生成。 公开了用于抑制血管发生和/或淋巴管生成的方法和组合，以及用于治疗与过度血管发生相关的病症，例如肿瘤和/或视网膜病变，以及与淋巴管生成相关的病症，例如恶性肿瘤的转移性扩散，黄斑变性，炎性 介导的疾病，类风湿性关节炎，糖尿病性视网膜病变和银屑病。 本发明的方法和组合物使用选自抗前体蛋白转化酶抗体，针对编码前蛋白转化酶的多核苷酸的反义核酸分子和用于抑制前蛋白转化酶表达的siRNA以及前蛋白转化酶 抑制剂。
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