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公开(公告)号：US20120021414A1
公开(公告)日：2012-01-26
申请号：US13168974
申请日：2011-06-25
申请人： Shai S. Shen-Orr , Atul J. Butte , Mark M. Davis , David Furman , Brian A. Kidd
发明人： Shai S. Shen-Orr , Atul J. Butte , Mark M. Davis , David Furman , Brian A. Kidd
CPC分类号： G01N33/5091 , G01N2333/52 , G01N2333/70514 , G01N2333/70517 , G01N2333/70521 , G01N2800/60
摘要： Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyses, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines (‘cytokine response’). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases.
摘要翻译： 本发明的实施方案提供了免疫衰老的诊断标记和基于从各种分析（主要来自血液，测试免疫功能，包括免疫细胞亚群频率分析，基因表达， 细胞因子和趋化因子水平，以及用细胞因子刺激的信号转导（'细胞因子反应'）。 标志物的特殊组合可以高精度预测个体是否对活动性疫苗接种作出反应，并且可以防止复发性疾病。
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2.发明授权公开(公告)号：US08313308B2
公开(公告)日：2012-11-20
申请号：US10810123
申请日：2004-03-26
申请人： Michael W. Lawless , Marwan A. Fathallah , Mansour A. Saleki , Brian A. Kidd , Kent D. Abrahamson , Robert P. Cousineau , Robert R. Boyd , Howard L. Greene
发明人： Michael W. Lawless , Marwan A. Fathallah , Mansour A. Saleki , Brian A. Kidd , Kent D. Abrahamson , Robert P. Cousineau , Robert R. Boyd , Howard L. Greene
CPC分类号： A61M5/14224 , A61M5/16809 , A61M5/16854 , A61M5/172 , A61M2205/128 , A61M2205/3331
摘要： A medical pump with a closed loop stroke feedback system and method, for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pumping element that intermittently pressurizes a pumping chamber during a pumping cycle. A pressure sensor detects the pressure exerted by the pumping element on the pumping chamber. A position sensor detects the position of the pumping element. A processing unit processes pressure data from the pressure sensor and position data from the position sensor to determine a calculated stroke volume of the pump for a pump cycle, and to adjust a stroke frequency of the pump to compensate for variation in the stroke volume.
摘要翻译： 公开了一种具有闭环行程反馈系统和方法的医用泵，其用于例如在盒中的泵送室。 泵包括泵送元件，其在泵送循环期间间歇地加压泵送室。 压力传感器检测泵送元件在泵送室上施加的压力。 位置传感器检测泵送元件的位置。 处理单元处理来自压力传感器的压力数据和来自位置传感器的位置数据，以确定用于泵循环的泵的计算行程量，并且调节泵的行程频率以补偿行程体积的变化。
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公开(公告)号：US07905710B2
公开(公告)日：2011-03-15
申请号：US11510106
申请日：2006-08-25
申请人： David T. Wang , Peter J. Scaramuzzi , Mansour A. Saleki , Robert P. Cousineau , Kent D. Abrahamson , Michael W. Lawless , Marwan A. Fathallah , Brian A. Kidd , Robert R. Boyd , Howard L. Greene , Eric R. Navin , Lori E. Lucke , Benjamin T. Mullin
发明人： David T. Wang , Peter J. Scaramuzzi , Mansour A. Saleki , Robert P. Cousineau , Kent D. Abrahamson , Michael W. Lawless , Marwan A. Fathallah , Brian A. Kidd , Robert R. Boyd , Howard L. Greene , Eric R. Navin , Lori E. Lucke , Benjamin T. Mullin
CPC分类号： A61M5/14224 , A61M5/16809 , A61M5/16854 , A61M5/172 , A61M2205/128 , A61M2205/3331
摘要： A medical pump with an improved continuity low flow delivery system and method for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pump drive for exerting a force on the pumping chamber and a sensor for sensing the force/pressure exerted by the pump drive on the pumping chamber. The pump drive position sensor senses the position of the pump drive. The medical pump also includes a processing unit and a memory having a programming code adapted to calculate the rate of change of the sensed force/pressure values and determine whether the rate of change of the sensed force/pressure values meets a rate of change threshold. Once the rate of change threshold is met, the programming code is adapted to calculate a remaining pump drive travel value for determining how much farther the pump drive should travel before the end of an effective pump cycle. The programming code is further adapted to trigger one or more signals to drive the pump drive for the remainder of the effective pump cycle using the remaining pump drive travel value.
摘要翻译： 公开了一种具有改进的连续性低流量输送系统的医疗泵以及用于例如在盒中的泵送室的方法。 泵包括用于在泵送室上施加力的泵驱动器和用于感测泵驱动器在泵送室上施加的力/压力的传感器。 泵驱动位置传感器检测泵驱动器的位置。 医疗泵还包括处理单元和具有适于计算检测到的力/压力值的变化率的编程代码的存储器，并且确定检测到的力/压力值的变化率是否满足变化率阈值。 一旦满足了变化率阈值，编程代码就适用于计算剩余的泵驱动行程值，用于确定泵驱动器在有效泵循环结束之前要行进的距离。 编程代码还适用于使用剩余的泵驱动行程值来触发一个或多个信号来驱动泵驱动器的剩余有效泵循环。
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公开(公告)号：US10119959B2
公开(公告)日：2018-11-06
申请号：US13168974
申请日：2011-06-25
申请人： Shai S. Shen-Orr , Atul J. Butte , Mark M. Davis , David Furman , Brian A. Kidd
发明人： Shai S. Shen-Orr , Atul J. Butte , Mark M. Davis , David Furman , Brian A. Kidd
摘要： Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyzes, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines (‘cytokine response’). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases.
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