DIAGNOSTIC MARKERS OF IMMUNOSENESCENCE AND METHODS OF USE THEREOF
    3.
    发明申请
    DIAGNOSTIC MARKERS OF IMMUNOSENESCENCE AND METHODS OF USE THEREOF 审中-公开
    免疫球蛋白的诊断标记及其使用方法

    公开(公告)号:US20120021414A1

    公开(公告)日:2012-01-26

    申请号:US13168974

    申请日:2011-06-25

    IPC分类号: C12Q1/68 G01N33/53

    摘要: Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyses, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines (‘cytokine response’). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases.

    摘要翻译: 本发明的实施方案提供了免疫衰老的诊断标记和基于从各种分析(主要来自血液,测试免疫功能,包括免疫细胞亚群频率分析,基因表达, 细胞因子和趋化因子水平,以及用细胞因子刺激的信号转导('细胞因子反应')。 标志物的特殊组合可以高精度预测个体是否对活动性疫苗接种作出反应,并且可以防止复发性疾病。