公开(公告)号：US07071293B1

公开(公告)日：2006-07-04

申请号：US09642744

申请日：2000-08-18

Applicant: Brian F. Tack ,  Paul B. McCray, Jr. ,  Michael Welsh ,  Sue M. Travis ,  Robert Lehrer

Inventor： Brian F. Tack ,  Paul B. McCray, Jr. ,  Michael Welsh ,  Sue M. Travis ,  Robert Lehrer

IPC: A61K38/00 ,  A61K38/04 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07K5/00 ,  C07K7/00

CPC classification number: C07K14/4723 ,  A61K38/00

Abstract: The present invention relates to the use of antimicrobial peptides in the inhibition of microbial growth and proliferation. Novel antimicrobial truncated peptides are disclosed which are based upon SMAP 29 and RCAP 18, but which contain a lesser number of amino acid residues yet still retain bactericidal activity. In addition, synthetic peptides based upon the SMAP 29 protein are disclosed which have fewer amino acid residues and include substitutions yet retain substantial activity. The invention also relates to a method of inhibiting microbial growth by administering an effective amount of a peptide in accordance with the invention, or by combining the peptides with other antimicrobial agents or antibiotics.

Abstract translation: 本发明涉及抗微生物肽在抑制微生物生长和增殖中的用途。 公开了基于SMAP 29和RCAP 18但是含有较少数目的氨基酸残基但仍保留杀菌活性的新型抗微生物截短肽。 此外，公开了基于SMAP 29蛋白的合成肽，其具有较少的氨基酸残基，并且包括取代，但保留了相当大的活​​性。 本发明还涉及通过施用有效量的根据本发明的肽或通过将肽与其它抗微生物剂或抗生素组合来抑制微生物生长的方法。

公开(公告)号：US06809181B2

公开(公告)日：2004-10-26

申请号：US09872852

申请日：2001-06-01

Applicant: Paul B. McCray, Jr. ,  Brian F. Tack ,  Hong Peng Jia ,  Brian C. Schutte

Inventor： Paul B. McCray, Jr. ,  Brian F. Tack ,  Hong Peng Jia ,  Brian C. Schutte

IPC: C07K100

CPC classification number: C07K14/4723 ,  A61K38/00

Abstract: The present invention relates a novel antimicrobial peptide HBD-3 and derivatives thereof as well as the gene encoding the peptide. The invention further relates to methods of use of the HBD-3 peptide including a method of inhibiting microbial growth by administering an effective amount of the HBD-3 peptide alone or in combinination with other antimicrobial agents or antibiotics. In addition, the immunomodulatory properties of the HBD-3 peptide also facilitate the manipulation of the immune response, i.e., as a chemoattractant for immature dentritic cells or memory T cells.

Abstract translation: 本发明涉及新型抗菌肽HBD-3及其衍生物以及编码该肽的基因。 本发明还涉及使用HBD-3肽的方法，包括通过单独施用有效量的HBD-3肽或与其它抗微生物剂或抗生素组合来抑制微生物生长的方法。 此外，HBD-3肽的免疫调节特性也有助于免疫应答的操作，即作为未成熟的树突细胞或记忆T细胞的化学引诱物。

公开(公告)号：US06492328B2

公开(公告)日：2002-12-10

申请号：US09840009

申请日：2001-04-19

Applicant: Robert I. Lehrer ,  Alan J. Waring ,  Brian F. Tack

Inventor： Robert I. Lehrer ,  Alan J. Waring ,  Brian F. Tack

IPC: A61K3800

CPC classification number: C07K7/08 ,  A61K38/00 ,  Y02A50/473

Abstract: Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.