-
公开(公告)号：US5654276A
公开(公告)日：1997-08-05
申请号：US478312
申请日：1995-06-07
摘要： Described are peptides and peptide mimetics that bind to and the IL-receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of eosinophils, such as asthma, as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合IL和受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗涉及IL-5的不适当产生或应答以及嗜酸性粒细胞如哮喘的产生和积累以及使用标记肽和肽模拟物的诊断方法中的疾病的方法。
-
公开(公告)号：US5677280A
公开(公告)日：1997-10-14
申请号：US476169
申请日：1995-06-07
CPC分类号： C07K14/5409 , A61K38/00 , Y10S530/866
摘要： Described are peptides and peptide mimetics that bind to and the IL-5 receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of eosinophils, such as asthma, as well as in diagnostic methods employing labeled peptides and peptide mimetics.
-
公开(公告)号：US5668110A
公开(公告)日：1997-09-16
申请号：US485302
申请日：1995-06-07
CPC分类号： C07K7/08 , C07K14/5409 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and the IL-5 receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of eosinophils, such as asthma, as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合IL-5受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗涉及IL-5的不适当产生或应答以及嗜酸性粒细胞如哮喘的产生和积累以及使用标记肽和肽模拟物的诊断方法中的疾病的方法。
-
公开(公告)号：US5683983A
公开(公告)日：1997-11-04
申请号：US484083
申请日：1995-06-07
CPC分类号： C07K14/5409 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and the IL-5 receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of eosinophils, such as asthma, as well as in diagnostic methods employing labeled peptides and peptide mimetics.
-
公开(公告)号：US5264565A
公开(公告)日：1993-11-23
申请号：US645029
申请日：1991-01-22
CPC分类号： C07K14/723
摘要： Chimeric G-protein linked receptors are constructed which retain ligand binding specificity yet gain the ability to elevate intracellular free calcium as a result of agonist binding. This easily assayed function is provided by the insertion of or replacement with sequences substantially homologous to the i3 loop of a second G-protein-linked receptor. Such receptors are employed, for example, in methods of screening for compounds capable of acting as agonists or antagonists of G-protein-linked receptors.
摘要翻译： 构建了嵌合的G蛋白连接的受体，其保持配体结合特异性，但是由于激动剂结合而获得提升细胞内游离钙的能力。 通过插入或替换与第二G蛋白连接的受体的i3环基本上同源的序列来提供这种容易测定的功能。 这样的受体用于例如筛选能够作为G蛋白连接受体的激动剂或拮抗剂的化合物的方法。
-
-
-
-
搜索结果
5 条记录 (耗时 0.018 秒)
