-
1.发明授权
公开(公告)号：US4138476A
公开(公告)日：1979-02-06
申请号：US821275
申请日：1977-08-03
CPC分类号： A61K8/66 , A61K47/4843 , A61Q11/00
摘要： An oral therapeutic substance is formed by modifying a plaque-dispersing enzyme to control and reduce the occurrence of dental caries and periodontal diseases. In one embodiment, the modification is performed by introducing a suitable complexing reagent in combination with carrier and plaque-dispersing glucanohydrolase molecules to molecularly alter the glucanohydrolase. The modification, while having insignificant effects on the catalytic activity of the enzyme, will increase the binding capability of the enzyme to substances of which the tooth surface is formed. The activity of the enzyme on the tooth surface will therefore be maintained for longer periods of time to combat plaque build-up.
摘要翻译： 通过改变斑块分散酶来控制和减少龋齿和牙周病的发生形成口服治疗物质。 在一个实施方案中，通过将合适的络合试剂与载体和斑块分散葡聚糖水解酶分子组合引入分子改变葡聚糖水解酶来进行修饰。 该修饰虽然对酶的催化活性没有显着影响，但会增加酶与牙齿表面形成的物质的结合能力。 因此，在牙齿表面上的酶的活性将保持较长时间以抵抗斑块积聚。
-
公开(公告)号：US4328313A
公开(公告)日：1982-05-04
申请号：US232595
申请日：1981-02-09
CPC分类号： C12Y302/01071 , C12N9/2402 , C12Y302/01084 , A61K38/00 , Y10S435/874
摘要： A method of producing .alpha.-1, 3-glucanase by introducing a bacterial culture such as Pseudomonas sp. isolate NRRL B-12324 into an aqueous medium containing a "limit glucan" substrate which is greater than 90 percent .alpha.-1, 3-glycosidically linked, then allowing growth to take place to accumulate .alpha.-1, 3-glucanase, and then recovering the enzyme for use as an oral therapeutic agent.
摘要翻译： 通过引入细菌培养物如假单胞菌属（Pseudomonas sp。）来产生α-1,3-葡聚糖酶的方法。 将NRRL B-12324分离成含有“极性葡聚糖”底物的水性培养基，其大于90％的α-1,3-糖苷连接，然后允许生长以积累α-1,3-葡聚糖酶，然后回收 用作口服治疗剂的酶。
-
搜索结果
2 条记录 (耗时 0.012 秒)
