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公开(公告)号：US09206408B2
公开(公告)日：2015-12-08
申请号：US13620306
申请日：2012-09-14
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
IPC分类号： A61K38/16 , C12N9/24 , C12N9/10 , C12P21/00 , C07K14/00 , C12N9/40 , C12P21/06 , C07K14/39 , A61K38/00
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
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2.发明申请公开(公告)号：US20150337273A1
公开(公告)日：2015-11-26
申请号：US14641002
申请日：2015-03-06
申请人： OXYRANE UK LIMITED
CPC分类号： C12N9/1051 , C07K16/32 , C07K2317/14 , C07K2317/41 , C12N9/2402 , C12N9/2488 , C12N9/60 , C12N15/81 , C12P21/005 , C12Y204/01 , C12Y204/01133 , C12Y302/01024 , C12Y302/01084 , C12Y302/01114
摘要： Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosyiation pathway.
摘要翻译： 本文描述了可用于产生含有哺乳动物样复合N-聚糖或含有哺乳动物糖基化途径中的中间体的靶分子的方法和遗传工程真菌细胞。
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3.发明申请METHOD OF PRODUCING STARCH-CONTAINING FOOD AND ENZYME PREPARATION FOR MODIFYING STARCH-CONTAINING FOOD 审中-公开生产含淀粉食品的方法和用于修饰含淀粉食品的酶制剂公开(公告)号：US20150272174A1
公开(公告)日：2015-10-01
申请号：US14738048
申请日：2015-06-12
申请人： Ajinomoto Co., Inc.
发明人： Yuki SUZUKI , Koudai USUGI
CPC分类号： C12N9/107 , A21D8/042 , A23L29/06 , A23L29/212 , A23V2002/00 , C12N9/2408 , C12Y302/0102 , C12Y302/01084
摘要： Starch-containing foods having improved physical properties and taste may be obtained by adding a branching enzyme and an α-glucosidase.
摘要翻译： 通过添加分支酶和α-葡糖苷酶，可以获得具有改善的物理性质和味道的含淀粉的食品。
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4.发明申请METHODS FOR PREVENTING OR INHIBITING MICROBIAL INFECTION OF PLANTS AND PLANT EXHIBITING RESISTANCE TO MICROBIAL INFECTION 审中-公开预防或抑制植物微生物感染和植物感染微生物感染的方法公开(公告)号：US20120023616A1
公开(公告)日：2012-01-26
申请号：US13256904
申请日：2010-03-16
申请人： Marie Nishimura , Yoko Nishizawa , Takashi Fujikawa , Ichiro Mitsuhara , Eiichi Minami , Keietsu Abe , Takashi Tachiki , Shigekazu Yano
发明人： Marie Nishimura , Yoko Nishizawa , Takashi Fujikawa , Ichiro Mitsuhara , Eiichi Minami , Keietsu Abe , Takashi Tachiki , Shigekazu Yano
IPC分类号： A01H1/00 , A61K38/47 , C12N5/10 , A61P31/04 , A01H5/00 , A61K35/66 , A61P31/10 , A01H5/10 , A61K35/74 , C12N15/82
CPC分类号： C12N15/8282 , C12N9/2402 , C12Y302/01084
摘要： This invention provides a method for preventing or inhibiting infection with a plant-infecting microorganism and imparting resistivity to plants, a method for preparing plants having resistance to diseases caused by microorganisms such as plant pathogenic filamentous fungi, and a microbial pesticide formulation. The method for preventing or inhibiting infection of a host plant with plant-infecting microorganisms comprises degrading α-1,3-glucan on cell walls of the microorganisms by α-1,3-glucanase.
摘要翻译： 本发明提供一种预防或抑制植物感染微生物感染并赋予植物电阻率的方法，一种制备具有抗病性的植物的方法，所述微生物如植物病原性丝状真菌和微生物农药制剂具有抗性。 用植物感染微生物预防或抑制宿主植物感染的方法包括通过α-1,3-葡聚糖酶降解微生物细胞壁上的α-1,3-葡聚糖。
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公开(公告)号：US5874275A
公开(公告)日：1999-02-23
申请号：US956268
申请日：1997-10-22
IPC分类号： C12N15/09 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12N15/00 , C12N15/55 , C12R1/07 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/785 , C12R1/80 , C12R1/84 , C12R1/85 , C07H21/04 , C12N1/20
CPC分类号： C12Y302/01084 , C12N9/2402 , Y10S435/933 , Y10S435/935
摘要： The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
摘要翻译： 本发明涉及具有衍生葡聚糖酶活性的多肽和分离的编码多肽的核酸序列。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。 本发明还涉及口腔组合物和降解变应原的方法。
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公开(公告)号：US20190233802A1
公开(公告)日：2019-08-01
申请号：US16381523
申请日：2019-04-11
申请人： Oxyrane UK Limited
CPC分类号： C12N9/1051 , C07K16/32 , C07K2317/14 , C07K2317/41 , C12N9/2402 , C12N9/2488 , C12N9/60 , C12N15/81 , C12P21/005 , C12Y204/01 , C12Y204/01133 , C12Y302/01024 , C12Y302/01084 , C12Y302/01114
摘要： Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway.
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公开(公告)号：US20130195835A1
公开(公告)日：2013-08-01
申请号：US13620259
申请日：2012-09-14
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
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公开(公告)号：US20130190253A1
公开(公告)日：2013-07-25
申请号：US13620306
申请日：2012-09-14
申请人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
发明人： Nico Luc Marc Callewaert , Wouter Vervecken , Karen Jacqueline Marcel De Pourcq , Steven Christian Jozef Geysens , Mouna Guerfal
IPC分类号： C07K14/00
CPC分类号： C12N9/2488 , A61K38/00 , C07K14/00 , C12N9/1051 , C12N9/24 , C12N9/2402 , C12N9/2465 , C12P21/005 , C12P21/06 , C12Y204/01232 , C12Y302/01024 , C12Y302/01045 , C12Y302/01046 , C12Y302/01084 , C12Y302/01113 , Y02P20/52
摘要： Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
摘要翻译： 本文描述了可用于产生改变的N-糖基化形式的靶分子的方法和遗传工程改造的细胞。 还描述了具有改变的N-糖基化的方法和分子，其可用于治疗各种疾病如代谢紊乱。
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公开(公告)号：US20060110795A1
公开(公告)日：2006-05-25
申请号：US11225804
申请日：2005-09-12
申请人： Roland Contreras , Steven Geysens
发明人： Roland Contreras , Steven Geysens
CPC分类号： C12Y302/01113 , C12N9/2434 , C12P21/00 , C12Y204/0115 , C12Y302/0102 , C12Y302/01084
摘要： The present invention relates to the use of a glucosidase II mutation to increase protein secretion in eukaryotic cells. The present invention relates further to the use of eukaryotic cells, comprising a mutant glucosidase II gene, possibly in combination with the expression of a recombinant α-1,2-mannosidase gene and/or a recombinant N-acetylglucosaminyl-transferase gene, as a host for protein secretion.
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公开(公告)号：US20020157123A1
公开(公告)日：2002-10-24
申请号：US10014511
申请日：2001-12-14
IPC分类号： A01K067/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A01K2267/03 , A23C9/20 , A23C2230/05 , A61K38/47 , C12N9/2408 , C12Y302/01084
摘要： The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, methods of generating the same, pharmaceutical compositions for use in enzyme replacement therapy, and methods of treating Pompe's disease using human acid alpha glucosidase.
摘要翻译： 本发明提供了在其乳中产生磷酸化溶酶体蛋白质的转基因非人哺乳动物，其生产方法，用于酶替代疗法的药物组合物，以及使用人类α-糖苷酶处理庞培氏病的方法。
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