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    NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF
    3.
    发明申请
    NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF 有权
    纳米材料组合物及其相关方法

    公开(公告)号：US20120156141A1

    公开(公告)日：2012-06-21

    申请号：US12968577

    申请日：2010-12-15

    Applicant: Bruce Allan Hay ,  Brian Christopher Bales ,  Michael Todd Luttrell ,  Binil Itty Ipe Kandapallil

    Inventor： Bruce Allan Hay ,  Brian Christopher Bales ,  Michael Todd Luttrell ,  Binil Itty Ipe Kandapallil

    IPC: A61K49/18 ,  A61P35/00 ,  B82Y30/00

    CPC classification number: A61K49/1842 ,  A61K49/1845 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

    Abstract: A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

    Abstract translation: 提供纳米颗粒组合物，其中所述组合物包含纳米颗粒金属氧化物; 和包含至少两个磷酸酯基团的磷酸化多元醇。 多元醇包含一个或多个选自聚乙烯醚部分，聚丙烯醚部分，聚丁烯醚部分以及前述亲水部分中两个或更多个的组合的亲水基团。 还提供了制备纳米颗粒组合物的方法。 本发明提供的纳米颗粒组合物可用作医学成像技术如X射线和磁共振成像中的造影剂。

    Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells
    6.
    发明授权
    Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells 有权
    具有PEG取代的α-羟基膦酸酯壳的超顺磁性纳米颗粒

    公开(公告)号：US09474810B2

    公开(公告)日：2016-10-25

    申请号：US13411004

    申请日：2012-03-02

    Applicant: Bruce Allan Hay ,  Daniel Eugene Meyer ,  Brian Christopher Bales ,  Michael Todd Luttrell

    Inventor： Bruce Allan Hay ,  Daniel Eugene Meyer ,  Brian Christopher Bales ,  Michael Todd Luttrell

    IPC: A61K49/18 ,  A61K47/48 ,  A61K33/26 ,  A61K33/28 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34

    CPC classification number: A61K49/186 ,  A61K33/24 ,  A61K33/26 ,  A61K33/32 ,  A61K33/34 ,  A61K47/548 ,  A61K47/60 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1842 ,  Y10T428/2982

    Abstract: The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an α-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.

    Abstract translation: 本申请公开了纳米颗粒，特别是超顺磁性氧化铁的纳米颗粒，其可用于铁疗法和诸如磁共振（MR）的诊断成像。 所公开的纳米颗粒已经用含有聚乙二醇作为亲水部分的α-羟基膦酸缀合物进行处理，以使纳米颗粒充分亲水以发现在诊断成像中的应用。 所公开的改性亲水性纳米粒子是其中改性缀合物的亲水部分是聚环氧乙烷基聚合物并具有大于5,000道尔顿且小于或等于约30,000道尔顿的分子量的那些。 令人惊讶的是，与其中基于PEG的亲水部分具有小于5,000的分子量的类似纳米颗粒相比，这些纳米颗粒在保留的纳米颗粒的肝中具有更快速和完整的加工。

    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS
    7.
    发明申请
    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS 有权
    用水解ALPHA-羟基磷酸共聚物处理水不溶性纳米颗粒，该改性纳米粒子及其作为对比剂的用途

    公开(公告)号：US20160038617A1

    公开(公告)日：2016-02-11

    申请号：US14919077

    申请日：2015-10-21

    Applicant: General Electric Company

    Inventor： Brian Christopher Bales ,  Bruce Allan Hay ,  Binil Itty Ipe Kandapallil

    IPC: A61K49/18

    CPC classification number: A61K49/1857 ,  A61K49/0428 ,  A61K49/1842 ,  A61K49/186 ,  B82Y5/00

    Abstract: The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.

    Abstract translation: 本申请公开了处理水不溶性纳米颗粒，特别是金属和金属化合物的纳米颗粒，其在诊断成像如MR和X射线成像中具有与亲水部分的α-羟基膦酸缀合物的效用，以使纳米颗粒充分亲水以发现 在诊断成像中的应用。 所公开的改性亲水性纳米粒子中的那些是其中改性缀合物的亲水部分是环氧乙烷基聚合物和共聚物和两性离子，并且纳米颗粒由过渡金属氧化物如超顺磁性氧化铁和氧化钽组成。 公开了足够亲水以形成稳定的水性胶体悬浮液的纳米颗粒。 还公开了使用修饰的亲水性纳米颗粒作为造影剂的诊断成像如MR和X射线。

    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS
    10.
    发明申请
    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS 有权
    用水解ALPHA-羟基磷酸共聚物处理水不溶性纳米颗粒，该改性纳米粒子及其作为对比剂的用途

    公开(公告)号：US20110104072A1

    公开(公告)日：2011-05-05

    申请号：US12609799

    申请日：2009-10-30

    Applicant: Brian Christopher Bales ,  Bruce Allan Hay ,  Binil Itty Ipe Kandapallil

    Inventor： Brian Christopher Bales ,  Bruce Allan Hay ,  Binil Itty Ipe Kandapallil

    IPC: A61K49/08 ,  C07F9/38 ,  C08G61/04 ,  A61K49/04

    CPC classification number: A61K49/1857 ,  A61K49/0428 ,  A61K49/1842 ,  A61K49/186 ,  B82Y5/00

    Abstract: The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.

    Abstract translation: 本申请公开了处理水不溶性纳米颗粒，特别是金属和金属化合物的纳米颗粒，其在诊断成像如MR和X射线成像中具有与亲水部分的α-羟基膦酸缀合物的效用，以使纳米颗粒充分亲水以发现 在诊断成像中的应用。 所公开的改性亲水性纳米粒子中的那些是其中改性缀合物的亲水部分是环氧乙烷基聚合物和共聚物和两性离子，并且纳米颗粒由过渡金属氧化物如超顺磁性氧化铁和氧化钽组成。 公开了足够亲水以形成稳定的水性胶体悬浮液的纳米颗粒。 还公开了使用修饰的亲水性纳米颗粒作为造影剂的诊断成像如MR和X射线。

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