-
公开(公告)号:US11635367B2
公开(公告)日:2023-04-25
申请号:US16063652
申请日:2016-12-16
申请人: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DU MANS
IPC分类号: G01N21/01 , G01N33/543 , G02B1/11 , G01N21/552 , G01N21/64 , G01N21/65
摘要: A contrast-amplifying carrier for observing a sample, includes a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength λ through the substrate and when the face of the coating opposite the substrate is in contact with a medium referred to as a transparent ambient medium, the refractive index n3 of which is lower than that of the refractive index n0 of the substrate. The absorbent coating comprises: an absorbent sublayer referred to as the contrast sublayer, deposited on the surface of the transparent substrate; and an absorbent layer referred to as the sensitive layer, distinct from the contrast sublayer and comprising between 1 and 5 sheets of a graphene-type material. Methods for producing and for using such a contrast-amplifying carrier are also provided.
-
公开(公告)号:US20230121377A1
公开(公告)日:2023-04-20
申请号:US18067120
申请日:2022-12-16
申请人: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
摘要: A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C. in the presence of at least one amine reactant selected from among hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof; b) drying the gel obtained during step a) so as to obtain a sol-gel matrix containing at least one amine reactant.
-
公开(公告)号:US11622978B2
公开(公告)日:2023-04-11
申请号:US16747198
申请日:2020-01-20
申请人: INSTITUT CURIE , Institut National de la Sante et da la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人: Sebastian Amigorena , Eliane Piaggio , Christel Goudot , Luigia Pace , Genevieve Almouzni , Leticia Niborski
IPC分类号: A61K35/17 , A61P35/02 , C07K14/725 , C07K14/705 , A61K45/06
摘要: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.
-
4.
公开(公告)号:US20230087997A1
公开(公告)日:2023-03-23
申请号:US17997153
申请日:2021-04-26
申请人: SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人: Guillaume RENAUD
IPC分类号: A61B8/08
摘要: Disclosed is a method for characterising an object, comprising: emission of ultrasonic waves that enter an object by passing through an external interface, then reflect off an internal interface, then exit the object by passing through the external interface again, the ultrasonic waves comprising first waves having a mode that varies according to a first variation during their propagation in the object, and second waves having a mode that varies according to a second variation during their propagation in the object; reception of echo signals comprising first signals representing echoes of the first waves, and second signals representing echoes of the second waves, construction of a plurality of images showing the object, the plurality of images being constructed from the echo signals, under the assumption that two characteristics of the object are equal to two candidate values, and comprising a first image constructed from the first signals, and a second constructed from the second signals; construction of a composite image from the plurality of images; calculation of a focus metric in the composite image and, depending on the metric, selection or not of the two candidate values as values of the two characteristics. These characteristics can be used, in particular, to estimate a thickness of the object between the two interfaces.
-
公开(公告)号:US11609124B2
公开(公告)日:2023-03-21
申请号:US17487313
申请日:2021-09-28
申请人: UNIVERSITE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SORBONNE UNIVERSITE
发明人: Marc Guillon , Gilles Tessier , Tengfei Wu , Pascal Berto
摘要: A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation Δαij defined by Δαij=arccos, where “·” stands for the inner product between and .
-
公开(公告)号:US11608315B2
公开(公告)日:2023-03-21
申请号:US16956201
申请日:2018-12-20
申请人: Arkema France , Université Lille 1—Sciences et Technologies , Centre National De La Recherche Scientifique—CNRS
IPC分类号: C07C319/06 , C01B32/77 , B01J21/06 , B01J23/28 , B01J35/10 , C07C319/02 , C07C321/04 , C01B32/70 , C07C319/28 , C07C319/14
摘要: The invention relates to a process for preparing methyl mercaptan from a mixture of carbon oxide, hydrogen sulfide and hydrogen, in the presence of a catalyst based on molybdenum and potassium supported on zirconia, said catalyst not comprising any promoter.
-
公开(公告)号:US20230066255A1
公开(公告)日:2023-03-02
申请号:US17793208
申请日:2021-01-15
申请人: HORIBA ABX SAS , UNIVERSITE DE MONTPELLIER , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: Pierre TARACONAT , Damien ISEBE , Simon MENDEZ , Franck NICOUD
IPC分类号: G01N15/12 , G01N33/487
摘要: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.
-
公开(公告)号:US20230044444A1
公开(公告)日:2023-02-09
申请号:US17931725
申请日:2022-09-13
申请人: VOYAGER THERAPEUTICS, INC. , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ DE STRASBOURG
发明人: Dinah Wen-Yee Sah , Martin Goulet , Holger Patzke , Yanqun Shu , Jinzhao Hou , Hélène Puccio
摘要: Described herein are compositions and methods for treating Friedreich's Ataxia (FA) using adeno-associated virus (AAV) to deliver therapeutics agents.
-
公开(公告)号:US20230032690A1
公开(公告)日:2023-02-02
申请号:US17818481
申请日:2022-08-09
申请人: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE LILLE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
发明人: Luc BUEE , Malika HAMDANE , David BLUM , Maxime DERISBOURG , Coline LEGHAY , Giovanni CHIAPPETTA , Joelle VINH , Yann VERDIER
摘要: The invention relates to the identification of a new Tau species starting at residue Met11 (Met11-Tau) which is N-alpha-terminally acetylated form (N-alpha-acetyl-Met11-Tau species: Ac-Met11-Tau). Several monoclonal antibodies specific of this new Tau species have been developed. One of this antibody, 2H2/D11, was used in THY-Tau22 mouse model (that develops with age neurofibrillary degeneration (NFD) and memory deficits), and N-alpha-Ac-Met11-Tau species were clearly detected early in neurons displaying NFD on hippocampal brain sections while it is not reactive in hippocampus from elderly controls. Finally, by using ELISA sandwich specific of Ac-Met11-Tau species, Alzheimer Disease (AD) brain samples are clearly discriminated from human elderly control brains. Thus the invention relates to this new Tau species starting from the methionine residue at position 11 said methionine being N-alpha acetylated. The invention also relates to antibody that specifically binds this new tau species, a method of detection of this new Tau species and a method of diagnosis of Tauopathy disorder.
-
10.
公开(公告)号:US20230028731A1
公开(公告)日:2023-01-26
申请号:US17783451
申请日:2020-12-09
申请人: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS
摘要: A method and a system for measuring carrier-to-envelope phase fluctuations (CEP) fluctuations of a laser field, the method comprising focusing laser pulses in a solid-state material for high harmonic generation, collecting a resulting high harmonic spectrum, and inferring a relative phase of the driving field from the high harmonic spectrum. The system comprises a source of CEP stable mid-infrared laser pulses; a CEP variation unit; a solid state medium; a detector; and first focusing optics focusing pulses generated by the source into the solid state medium and second focusing optics collecting resulting harmonics generated in the solid state medium into the detector.
-
-
-
-
-
-
-
-
-