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公开(公告)号：US20150224061A1
公开(公告)日：2015-08-13
申请号：US14415916
申请日：2013-07-19
发明人： Francesca Granucci , Davide Prosperi , Ivan Zanoni , Fabio Ruggero Maria Corsi , Miriam Colombo
CPC分类号： A61K9/5138 , A61K9/5115 , A61K38/1709 , A61K47/6935 , A61K49/1851 , C07K14/47
摘要： The present invention relates to methods and means of transport of active substances in the cell cytosol. In particular, the invention relates to means that make it possible to transport directly in the cytosol substances capable of interacting with protein systems, such as the family of nuclear factors of activated T-cells (NFATs) or nucleic acids localized in the cytosol. In particular, the invention relates to nanoconstructs useful in the treatment of inflammatory diseases, methods for their preparation, and compositions containing them.
摘要翻译： 本发明涉及活细胞在细胞质中的运输方法和方法。 特别地，本发明涉及使得能够直接在能够与蛋白质系统（例如活化的T细胞的核因子（NFAT）家族）或定位于胞质溶胶中的核酸相互作用的细胞质物质中转运的手段。 特别地，本发明涉及可用于治疗炎性疾病的纳米结构，其制备方法和含有它们的组合物。
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公开(公告)号：US11956014B2
公开(公告)日：2024-04-09
申请号：US17603085
申请日：2020-04-02
发明人： Marco Potenza , Bruno Paroli , Mirko Siano
CPC分类号： H04B10/118 , G02F2/008 , H04B7/18515 , H04B10/11 , H04B10/541 , H04J14/02
摘要： A method for transmitting and receiving an electromagnetic radiation beam, adapted to determine an orbital angular momentum of the received electromagnetic radiation beam, is described. There is further described a system for transmitting and receiving an electromagnetic radiation beam, capable of performing the aforesaid method. A method for performing a telecommunication of signals modulated according to any modulation technique and grouped by means of orbital angular momentum multiplexing is further described. There is further described a telecommunication system capable of performing the aforesaid method for performing a telecommunication of modulated signals.
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3.发明公开公开(公告)号：US20230327672A1
公开(公告)日：2023-10-12
申请号：US18036433
申请日：2021-11-04
发明人： Paolo MILANI , Matteo MIRIGLIANO , Bruno PAROLI
IPC分类号： H03K19/02
CPC分类号： H03K19/02
摘要： The invention relates to an electronic computing device for generating Boolean functions. The device comprises a conductive module comprising one or more first electrodes, to allow the application of electrical input signals to the conductive module, and one or more second electrodes, to make available electrical output signals from the conductive module. The device comprises one or more input terminals, each of which is selectively connectible to one of said one or more first electrodes for applying electrical input signals to said first electrodes during a step of processing of the device, and one or more output terminals, each of which is selectively connectible to one of said second electrodes to make electrical output signals available on said second electrodes during the step of processing.
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公开(公告)号：US20230279509A1
公开(公告)日：2023-09-07
申请号：US18017802
申请日：2021-07-29
申请人： ISTITUTO NAZIONALE DI ASTROFISICA , UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" , ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA , UNIVERSITA' DEGLI STUDI DI MILANO , POLITECNICO DI MILANO
发明人： Francesca ESPOSITO , John Robert BRUCATO , Fabio COZZOLINO , Giuseppe MONGELLUZZO , Ciprian lonut POPA , Teresa FORNARO , Andrea MENEGHIN , Daniele PAGLIALUNGA , Giovanni PARESCHI , Giampiero DE CESARE , Domenico CAPUTO , Augusto NASCETTI , Francesca COSTANTINI , Nicola LOVECCHIO , Lorenzo IANNASCOLI , Mara MIRASOLI , Elisa MICHELINI , Massimo GUARDIGLI , Mario CLERICI , Daria TRABATTONI , Mara BIASIN , Diego SCACCABAROZZI
IPC分类号： C12Q1/70 , G01N1/22 , G01N1/24 , C12Q1/6806
CPC分类号： C12Q1/70 , G01N1/2273 , G01N1/24 , C12Q1/6806
摘要： An apparatus for sampling and detecting a pathogen in air comprising a first air sampling module, a second module for the isolation of viral RNA and a third module for amplification and detection of the viral RNA; thanks to the integration between the modules the apparatus is compact and portable and can be used for in situ sampling of air in closed environments such as ambulances or hospital rooms, air in the external environment and air exhaled by patients.
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公开(公告)号：US20230151428A1
公开(公告)日：2023-05-18
申请号：US17816210
申请日：2022-07-29
申请人： lstituto Europeo di Oncologia S.r.I. , Fondazione Istituto firc di Oncologia Molecolare (IFOM0) , Universita degli Studi di Milano (University of Milan)
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G16B5/00
摘要： The present invention relates to refined prognostic clinical tools, methods, and kits for the evaluation of risk and treatment of distant recurrence in ER+/HER2-breast cancer patients.
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公开(公告)号：US11441191B2
公开(公告)日：2022-09-13
申请号：US16308564
申请日：2017-06-19
申请人： Istituto Europeo di Oncologia (IEO) , Fondazione Istituto Firc di Oncologia Molecolare (IFOM) , Universita degli Studi di Milano (University of Milan)
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886 , G16B5/00 , G16B40/00
摘要： The present invention relates to refined prognostic clinical tools, methods, and kits for the evaluation of risk and treatment of distant recurrence in ER+/HER2− breast cancer patients.
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公开(公告)号：US20210399152A1
公开(公告)日：2021-12-23
申请号：US17289512
申请日：2019-10-28
发明人： Francesco MEINARDI , Sergio BROVELL , Francesco BRUNI , Marina GANDINI , Emillo SASSONE CORSI , Graziella GARIANO , Chiara CAPITANI
IPC分类号： H01L31/048 , E04C1/42 , E04C1/39
摘要： A glass brick having a luminescent solar concentrator inserted inside it, between the preformed glass portions which constitute the body of the glass brick is provided.
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8.发明授权公开(公告)号：US11038075B2
公开(公告)日：2021-06-15
申请号：US16096424
申请日：2017-04-24
摘要： The object of the invention is a luminescent solar concentrator having a vitreous or plastic matrix containing colloidal indirect band-gap semiconductor nanocrystals and in particular silicon nanocrystals.
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公开(公告)号：US20200283515A1
公开(公告)日：2020-09-10
申请号：US16648333
申请日：2018-09-19
摘要： The present invention refers to an antibody able to recognize and bind to an epitope comprised in a sequence of human Migration Stimulating Factor (MSF), and that doesn't recognize and bind human Fibronectin 1 (hFn1) and to uses in diagnostic methods and therapy.
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公开(公告)号：US20200095387A1
公开(公告)日：2020-03-26
申请号：US16469849
申请日：2017-12-18
发明人： Luciano TADIELLO , Valeria Rosaria CIPOLLETTI , Luca GIANNINI , Thomas HANEL , Maurizio GALIMBERTI , Roberto SCOTTI , Barbara DI CREDICO , Franca MORAZZONI , Massimiliano D'ARIENZO , Irene TAGLIARO
IPC分类号： C08J3/22 , C08L9/06 , C08L9/02 , C08L7/00 , C08K7/10 , C08K3/36 , C08K3/06 , C08K3/011 , B60C1/00
摘要： The present invention regards a solid master elastomeric composition (masterbatch, MB) comprising silicate fibres with needle-shaped morphology of nanometric size, characterised by high fibre content and uniformity, a process advantageous for the preparation thereof and its use in manufacturing tyres for vehicles. Advantageously the present elastomeric composition allows minimising the drawbacks associated with the handling of the powdery fibres in the manufacturing of compounds for tyres, without altering the final performances thereof.
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